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Michelle N. Clements, Christl A. Donnelly, Alan Fenwick, Narcis B. Kabatereine, Sarah C. L. Knowles, Aboulaye Meité, Eliézer K. N'Goran, Yolisa Nalule, Sarah Nogaro, Anna E. Phillips, Edridah Muheki Tukahebwa, Fiona M. Fleming
Interpreting ambiguous ‘trace’ results in Schistosoma mansoni CCA Tests: Estimating sensitivity and specificity of ambiguous results with no gold standard
www.plosntds.org
www.plosntds.org
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0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 319.6913 523.8425 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9921 0 Td
[( )6()]TJ
0.9694 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 350.3055 521.2913 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 353.7637 523.8425 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.9751 0 Td
( )Tj
0.9864 0 Td
()Tj
/F13 1 Tf
[()]TJ
0.7484 0 Td
[()12()]TJ
0.89 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 398.211 521.2913 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 408.5291 523.8425 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9977 0 Td
[()]TJ
0.3629 0 Td
[()12()]TJ
0.89 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 439.4834 521.2913 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )]TJ
1.2378 0 Td
[()12()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 451.8992 523.8425 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.9751 0 Td
()Tj
0.9807 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1112 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()11(\r)]TJ
0.8277 0 Td
[()-5()]TJ
/F15 1 Tf
()Tj
1.44 0 Td
()Tj
0.7144 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.4796 0 Td
( )Tj
/F13 1 Tf
0.9978 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 556.3275 521.2913 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 559.8425 523.8425 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
-33.029 -1.7517 Td
()Tj
0.7143 0 Td
()Tj
/F13 1 Tf
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 249.7889 503.8299 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 255.5149 506.3244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9977 0 Td
[( )]TJ
0.4763 0 Td
[()12()]TJ
0.7426 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 286.9795 503.8299 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 290.4944 506.3244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.5952 0 Td
( )Tj
0.9865 0 Td
()Tj
/F13 1 Tf
[()]TJ
0.7483 0 Td
[()12()]TJ
0.8901 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 331.937 503.8299 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 342.3118 506.3244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()7()]TJ
0.8277 0 Td
[()]TJ
0.4252 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 374.0598 503.8299 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )6()]TJ
1.7291 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 386.4755 506.3244 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
17.6994 0 Td
()Tj
/F7 1 Tf
(3)Tj
/F15 1 Tf
()Tj
/F13 1 Tf
-34.8488 -2.9876 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 219.7417 473.9527 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
0.7559 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 232.2141 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
1.0488 0 Td
[()11(\r)]TJ
0.822 0 Td
[()-5()]TJ
/F15 1 Tf
1.0658 0 Td
()Tj
0.7257 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.491 0 Td
( )Tj
/F13 1 Tf
0.9978 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 302.1732 473.9527 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 305.6314 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
()Tj
/F13 1 Tf
0.72 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 327.2881 473.9527 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 333.0141 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9977 0 Td
[()]TJ
0.3629 0 Td
[()12()]TJ
0.89 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 363.9685 473.9527 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 372.0755 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
()Tj
0.9921 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1055 0 Td
( )Tj
/F13 1 Tf
0.9978 0 Td
[()]TJ
0.4649 0 Td
[(\r)20()]TJ
0.7427 0 Td
[()]TJ
/F15 1 Tf
0.4592 0 Td
()Tj
0.5952 0 Td
()Tj
0.7257 0 Td
()Tj
/F13 1 Tf
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 452.0692 473.9527 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 457.7952 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.7199 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1112 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 495.3259 473.9527 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 498.7842 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()7()]TJ
0.8277 0 Td
[()]TJ
0.4252 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 536.5417 473.9527 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 544.6488 476.4472 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
1.8821 0 Td
()Tj
/F7 1 Tf
(4)Tj
/F15 1 Tf
()Tj
/F13 1 Tf
-34.9168 -2.9536 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 219.1181 444.4157 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.7653 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 229.0393 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
1.0488 0 Td
[()11(\r)]TJ
0.8277 0 Td
[()-5()]TJ
/F15 1 Tf
1.0658 0 Td
()Tj
0.72 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.4967 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 298.9984 444.4157 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 302.5133 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
()Tj
/F13 1 Tf
0.72 0 Td
[( )6()]TJ
0.9694 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 336.359 444.4157 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 342.085 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9977 0 Td
[()]TJ
0.3629 0 Td
[()12()]TJ
0.89 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 373.0393 444.4157 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )]TJ
1.2378 0 Td
[()12()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 385.4551 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.5952 0 Td
()Tj
0.9978 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1055 0 Td
( )Tj
/F13 1 Tf
0.9978 0 Td
[()]TJ
0.4649 0 Td
[(\r)20()]TJ
0.7427 0 Td
[()]TJ
/F15 1 Tf
0.4592 0 Td
()Tj
0.5952 0 Td
()Tj
0.7257 0 Td
()Tj
/F13 1 Tf
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 465.4488 444.4157 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 471.1748 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.7199 0 Td
[( )6()]TJ
0.9695 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 499.8614 444.4157 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 503.3763 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.771 0 Td
[()7()]TJ
0.8277 0 Td
[()]TJ
0.4252 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 532.9133 444.4157 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )6()]TJ
1.7291 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 545.3291 446.9102 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
1.8141 0 Td
()Tj
/F7 1 Tf
(5)Tj
/F15 1 Tf
()Tj
/F13 1 Tf
-34.9282 -3.084 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 219.0047 413.5181 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
0.7559 0 Td
( )Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 231.4204 416.0692 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
1.0488 0 Td
[()11(\r)]TJ
0.8277 0 Td
[()-5()]TJ
/F15 1 Tf
1.0658 0 Td
()Tj
0.7143 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.4797 0 Td
( )Tj
/F13 1 Tf
0.9978 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 301.2094 413.5181 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 304.7244 416.0692 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.5952 0 Td
()Tj
0.7143 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1056 0 Td
( )Tj
0.9864 0 Td
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 351.0425 413.5181 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 356.7685 416.0692 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9921 0 Td
[( )6()]TJ
0.9694 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 387.3826 413.5181 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 390.8409 416.0692 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.9751 0 Td
()Tj
0.9864 0 Td
()Tj
/F13 1 Tf
[()]TJ
0.7484 0 Td
[()12()]TJ
0.89 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 435.2881 413.5181 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 445.6062 416.0692 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9977 0 Td
[()]TJ
0.3629 0 Td
[()12()]TJ
0.8844 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 476.5039 413.5181 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )6()]TJ
1.7291 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 488.9763 416.0692 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.9751 0 Td
()Tj
0.9807 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1112 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()11(\r)]TJ
0.8221 0 Td
[()-5()]TJ
/F15 1 Tf
0.8447 0 Td
()Tj
0.6009 0 Td
()Tj
0.7087 0 Td
()Tj
/F13 1 Tf
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 572.485 413.5181 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 241.9086 398.5511 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.7143 0 Td
()Tj
/F13 1 Tf
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 262.2047 396.0566 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 267.9307 398.5511 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[( )6()]TJ
0.9694 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 299.3385 396.0566 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 302.8535 398.5511 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6009 0 Td
()Tj
0.9808 0 Td
()Tj
/F13 1 Tf
[()7()]TJ
1.2132 0 Td
[()]TJ
0.4252 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 344.3527 396.0566 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 354.6708 398.5511 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9977 0 Td
[()]TJ
0.3629 0 Td
[()12()]TJ
0.89 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 386.4188 396.0566 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )6()]TJ
1.7291 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 398.8913 398.5511 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
16.2027 0 Td
()Tj
/F7 1 Tf
(6)Tj
/F15 1 Tf
()Tj
/F7 1 Tf
-0.01 Tc
-36.0904 -2.3697 Td
(where)Tj
/F13 1 Tf
2.6192 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 230.9102 373.2094 cm
BT
/F13 1 Tf
1 TL
-0.0133 Tc
0 0 Td
[()36()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 242.4188 374.8535 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(denotes)Tj
3.2711 0 Td
(the)Tj
1.4513 0 Td
(proportion)Tj
4.5695 0 Td
(of)Tj
1.0034 0 Td
(people)Tj
2.8176 0 Td
(with)Tj
1.9786 0 Td
(a)Tj
0.6463 0 Td
(given)Tj
2.3471 0 Td
(test)Tj
1.576 0 Td
(combination)Tj
5.2838 0 Td
(for)Tj
1.3663 0 Td
(Kato-Katz)Tj
4.2519 0 Td
(\()Tj
/F13 1 Tf
[()]TJ
/F7 1 Tf
(\))Tj
-34.8035 -1.2982 Td
(and)Tj
1.7122 0 Td
(CCA)Tj
2.211 0 Td
(\()Tj
/F13 1 Tf
[()]TJ
/F7 1 Tf
(\)with)Tj
3.7699 0 Td
(Kato-Katz)Tj
4.2463 0 Td
(results)Tj
2.7666 0 Td
(being)Tj
2.4038 0 Td
(positive)Tj
3.2655 0 Td
(\(+\))Tj
1.4626 0 Td
(or)Tj
1.0885 0 Td
(negative)Tj
3.4866 0 Td
(\(-\))Tj
1.2302 0 Td
(and)Tj
1.7122 0 Td
(CCA)Tj
2.2166 0 Td
(results)Tj
2.7666 0 Td
(being)Tj
-34.3386 -1.3039 Td
(positive)Tj
3.2655 0 Td
(\(+\),)Tj
1.6837 0 Td
(trace)Tj
2.1373 0 Td
(\(t\))Tj
1.1849 0 Td
(or)Tj
1.0828 0 Td
(negative)Tj
3.4866 0 Td
(\(-\);)Tj
/F13 1 Tf
1.457 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 351.3259 347.1874 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 356.9952 348.8314 cm
BT
/F13 1 Tf
1 TL
-0.01 Tc
0 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 366.1795 347.1874 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 369.6944 348.8314 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(,)Tj
/F13 1 Tf
0.4365 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 382.4503 347.1874 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 388.1196 348.8314 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(and)Tj
/F13 1 Tf
1.7121 0 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 414.4251 347.1874 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 420.1511 348.8314 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(denote)Tj
2.9139 0 Td
(the)Tj
1.4514 0 Td
(sensitivity)Tj
4.1555 0 Td
(and)Tj
1.7122 0 Td
(specificity)Tj
4.1442 0 Td
(of)Tj
-36.3909 -1.2982 Td
(Kato-Katz)Tj
4.2463 0 Td
(and)Tj
1.7121 0 Td
(CCAtn)Tj
3.0501 0 Td
(respectively;)Tj
/F13 1 Tf
5.0343 0 Td
[( )6()12()-6()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 360.9637 334.2047 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 366.6897 335.8488 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(and)Tj
/F13 1 Tf
1.7121 0 Td
[( )6()12()14()]TJ
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 405.1842 334.2047 cm
BT
/F7 1 Tf
1 TL
-0.0133 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 410.9102 335.8488 cm
BT
/F7 1 Tf
1 TL
-0.01 Tc
0 0 Td
(denotes)Tj
3.2654 0 Td
(how)Tj
1.9219 0 Td
(much)Tj
2.4945 0 Td
(more)Tj
2.3187 0 Td
(sensitive)Tj
3.5716 0 Td
(and)Tj
-34.6617 -1.2982 Td
(less)Tj
1.5874 0 Td
(specific,)Tj
3.3619 0 Td
(respectively,)Tj
5.0343 0 Td
(CCA)Tj
2.211 0 Td
(becomes)Tj
3.6397 0 Td
(when)Tj
2.381 0 Td
(trace)Tj
2.143 0 Td
(is)Tj
0.8333 0 Td
(considered)Tj
4.5411 0 Td
(as)Tj
1.0034 0 Td
(positive)Tj
3.2712 0 Td
(rather)Tj
2.6078 0 Td
(than)Tj
2.007 0 Td
(nega-)Tj
-34.6221 -1.2983 Td
(tive;)Tj
1.8595 0 Td
(and)Tj
/F13 1 Tf
1.7122 0 Td
[()11(\r)20()-5()]TJ
/F7 1 Tf
1.8595 0 Td
(denotes)Tj
3.2655 0 Td
(the)Tj
1.4513 0 Td
(infection)Tj
3.736 0 Td
(prevalence)Tj
4.4277 0 Td
(in)Tj
1.0262 0 Td
(the)Tj
1.4513 0 Td
(population.)Tj
4.7507 0 Td
(The)Tj
1.7632 0 Td
(sensitivity)Tj
4.1555 0 Td
(of)Tj
1.0035 0 Td
(CCAtp)Tj
3.016 0 Td
(is)Tj
-35.4781 -1.3039 Td
(then)Tj
1.9956 0 Td
(equal)Tj
2.3244 0 Td
(to:)Tj
/F13 1 Tf
0 Tc
11.4405 -1.9162 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 366.0661 275.1874 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 371.7921 277.6818 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9921 0 Td
[( )6()]TJ
0.9694 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 402.4062 275.1874 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 563.4708 277.6818 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F7 1 Tf
(7)Tj
/F15 1 Tf
()Tj
/F7 1 Tf
-0.01 Tc
-36.3455 -2.2223 Td
(and)Tj
1.7121 0 Td
(the)Tj
1.4513 0 Td
(specificity)Tj
4.1442 0 Td
(of)Tj
1.0035 0 Td
(CCAtp)Tj
3.016 0 Td
(equals:)Tj
/F13 1 Tf
0 Tc
4.3483 -1.9162 Td
[()14()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 366.0661 233.8015 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 371.7921 236.296 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[( )6()]TJ
0.9694 0 Td
[()]TJ
0.703 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 403.2 233.8015 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 563.4708 236.296 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F7 1 Tf
(8)Tj
/F15 1 Tf
()Tj
/F7 1 Tf
-0.004 Tc
-35.1493 -2.3187 Td
(In)Tj
1.1111 0 Td
(a)Tj
0.652 0 Td
(similar)Tj
2.9877 0 Td
(manner)Tj
3.3675 0 Td
(to)Tj
1.0262 0 Td
(Dendukuri)Tj
4.6431 0 Td
(and)Tj
1.7291 0 Td
(Joseph)Tj
2.8857 0 Td
(\(2001\),)Tj
3.033 0 Td
(we)Tj
1.3266 0 Td
(place)Tj
2.2621 0 Td
(limits)Tj
2.4831 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(covariances:)Tj
/F15 1 Tf
0 Tc
-24.6442 -1.9219 Td
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 280.4031 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 286.1291 193.8897 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F17 1 Tf
0.9921 0 Td
(1)Tj
/F15 1 Tf
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.9955 0 Td
( )Tj
/F13 1 Tf
0.9922 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 334.4881 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 337.9464 193.8897 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6633 0 Td
()Tj
/F13 1 Tf
1.0488 0 Td
[()7()12()]TJ
1.7234 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 376.2708 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 387.1559 193.8897 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F18 1 Tf
1.0488 0 Td
[()2()1()]TJ
/F15 1 Tf
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 426.1039 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 429.6188 193.8897 cm
BT
/F16 1 Tf
1 TL
0 0 Td
(;)Tj
/F13 1 Tf
0.4365 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 442.4881 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 446.0031 193.8897 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6066 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 470.4944 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 476.2204 193.8897 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.7199 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 491.9244 191.3952 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 563.4708 193.8897 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F7 1 Tf
(9)Tj
/F15 1 Tf
()Tj
-31.4643 -2.948 Td
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 261.1842 161.9149 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 266.9102 164.4094 cm
BT
/F15 1 Tf
1 TL
0 0 Td
( )Tj
/F17 1 Tf
0.9977 0 Td
(1)Tj
/F15 1 Tf
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.9956 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 315.2692 161.9149 cm
BT
/F13 1 Tf
1 TL
0 0 Td
[( )6()12()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 323.2062 164.4094 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6576 0 Td
()Tj
/F13 1 Tf
1.0488 0 Td
[()7()12()]TJ
1.7234 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 361.474 161.9149 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )6()12()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 376.8377 164.4094 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F18 1 Tf
1.0488 0 Td
[()2()1()]TJ
/F15 1 Tf
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 415.7858 161.9149 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 419.244 164.4094 cm
BT
/F16 1 Tf
1 TL
0 0 Td
(;)Tj
/F13 1 Tf
0.4422 0 Td
[( )6()12()]TJ
1.2358 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 444.5291 161.9149 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 448.044 164.4094 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6066 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 472.5354 161.9149 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 478.2614 164.4094 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.7199 0 Td
[( )6()12()]TJ
1.6952 0 Td
[()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 506.3811 161.9149 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 558.7086 164.4094 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F7 1 Tf
(10)Tj
/F15 1 Tf
()Tj
-29.1796 -3.0897 Td
( )Tj
/F13 1 Tf
0.771 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 283.1244 131.0173 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 288.8503 133.5118 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.7199 0 Td
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 308.4094 131.0173 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 314.1354 133.5118 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9977 0 Td
[( )6()12()]TJ
1.2359 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 344.9763 131.0173 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 348.4913 133.5118 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6576 0 Td
()Tj
/F13 1 Tf
1.0488 0 Td
[()7()12()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 386.8157 131.0173 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F17 1 Tf
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 397.1338 133.5118 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9921 0 Td
[()7()12()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 428.3149 131.0173 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
/F16 1 Tf
(;)Tj
/F13 1 Tf
[( )6()12()]TJ
ET
Q
q
1 j
1 J
0 w
10 0 0 10 276.9448 115.9937 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F18 1 Tf
1.0488 0 Td
[()2()1()]TJ
/F15 1 Tf
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
2.7155 0 Td
( )Tj
/F13 1 Tf
0.9922 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 333.0141 113.4992 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 336.5291 115.9937 cm
BT
/F16 1 Tf
1 TL
0 0 Td
(;)Tj
/F17 1 Tf
0.4365 0 Td
(1)Tj
/F15 1 Tf
0.7256 0 Td
( )Tj
0.9865 0 Td
()Tj
/F13 1 Tf
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 370.3748 113.4992 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 376.1007 115.9937 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
/F13 1 Tf
0.9977 0 Td
[( )6()12()]TJ
1.2359 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 406.9417 113.4992 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 410.4566 115.9937 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.9864 0 Td
( )Tj
0.9921 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1055 0 Td
( )Tj
/F13 1 Tf
0.9921 0 Td
[()-6()]TJ
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.9998 459.7795 113.4992 cm
BT
/F17 1 Tf
1 TL
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 463.2377 115.9937 cm
BT
/F15 1 Tf
1 TL
0 0 Td
()Tj
0.6066 0 Td
()Tj
0.72 0 Td
()Tj
/F17 1 Tf
(1)Tj
/F15 1 Tf
1.1055 0 Td
( )Tj
0.9921 0 Td
()Tj
/F13 1 Tf
[()-6()]TJ
ET
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