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Stephen R. Doyle, Catherine Bourguinat, Hugues C. Nana-Djeunga, Jonas A. Kengne-Ouafo, Sébastien D. S. Pion, Jean Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C. Kuesel, Martin Walker, Maria-Gloria Basáñez, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Michel Boussinesq, Roger K. Prichard, Warwick N. Grant
Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
www.plosntds.org
www.plosntds.org
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[( )3()10(\n)15( )-13()4(\n)12()-4()]TJ
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(.)Tj
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1.1452 0 Td
[( )3()10(\n)15( )-13()4(\n)12()-4()]TJ
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(64)Tj
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3.2314 0 Td
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(the)Tj
1.4683 0 Td
(parasite)Tj
3.3279 0 Td
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-36.0734 -1.2983 Td
(low)Tj
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(due)Tj
1.7007 0 Td
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1.0262 0 Td
(ivermectin)Tj
4.5127 0 Td
(treatment)Tj
4.1386 0 Td
([)Tj
0.83 0.64 0.02 0 k
(69)Tj
0 g
(],)Tj
2.0749 0 Td
(and)Tj
1.7291 0 Td
(analysis)Tj
3.3279 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(reproductive)Tj
5.3348 0 Td
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(adult)Tj
2.2564 0 Td
(worms)Tj
-33.7547 -1.3039 Td
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(embryogram)Tj
5.3971 0 Td
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0.8447 0 Td
(typically)Tj
3.5603 0 Td
(\(but)Tj
1.8935 0 Td
(not)Tj
1.5761 0 Td
(exclusively\))Tj
4.8529 0 Td
(qualitatively)Tj
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4.1102 0 Td
(although)Tj
3.7531 0 Td
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2.7099 0 Td
(advances)Tj
3.8268 0 Td
(in)Tj
1.0318 0 Td
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(understanding)Tj
6.0718 0 Td
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1.0147 0 Td
(the)Tj
1.4684 0 Td
(genome)Tj
3.4072 0 Td
([)Tj
0.83 0.64 0.02 0 k
(70)Tj
0 g
(])Tj
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(transcriptome/prote-)Tj
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[()]TJ
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(.)Tj
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(71)Tj
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3.3676 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(http://parasite.wormbase.org/)Tj
0 g
(,)Tj
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(72)Tj
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[()]TJ
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(.)Tj
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[()]TJ
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ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 183.2882 23.6976 re
W* n
q
183.2315 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 296.7307 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Population)Tj
4.8543 0 Td
(genomics)Tj
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