@article { , title = {Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus).}, abstract = {We present a unique case of metastatic cholangiocarcinoma with concurrent abdominal cestodiasis in an African green monkey (Chlorocebus pygerythrus) that presented with respiratory insufficiency and abdominal discomfort. There were multiple white-grey masses in the liver and colonic serosa alongside intra-abdominal parasitic cysts. Histopathologically, the liver masses were composed of poorly-differentiated epithelial cells that formed densely cellular solid areas and trabeculae. The neoplastic cells were strongly immunopositive for CK7 but negative for Hep-Par1 antigen, which confirmed a diagnosis of cholangiocarcinoma. Interestingly, there was strong and diffuse neoexpression in the tumour of the cell cycle regulator 14-3-3σ, which is not constitutively expressed in normal liver. There was aberrantly strong expression of E-cadherin, a key cell-cell adhesion protein, in neoplastic cells with evidence of cytoplasmic internalization. This is the first immunohistochemical analysis of 14-3-3σ and E-cadherin in a liver neoplasm in an animal species and the use of these markers requires further investigation in animal liver neoplasms. [Abstract copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.]}, issn = {0021-9975}, journal = {Journal of Comparative Pathology}, note = {Comments and Suggestions : ** From PubMed via Jisc Publications Router ** History: received 20-04-2020; revised 04-06-2020; accepted 01-07-2020.}, pages = {25-30}, publicationstatus = {Published}, publisher = {Elsevier}, url = {https://rvc-repository.worktribe.com/output/1376254}, volume = {179}, keyword = {ePrints migration, 14-3-3σ, E-cadherin, cholangiocarcinoma, non-human primate}, year = {2020}, author = {Suárez-Bonnet, A and Priestnall, S L and Ramírez, G A and Molín, J and Jaber, J R} }