@article { , title = {Diabetes mellitus remission in a cat with pituitary-dependent hyperadrenocorticism after trilostane treatment}, abstract = {An 8-year-old male neutered Persian cat was presented with polyuria, polydipsia, polyphagia and muscle weakness associated with a 7 month history of diabetes mellitus (DM). The cat had initially been treated with neutral protamine Hagedorn (NPH) insulin 2 U q12h, followed by porcine lente insulin 2 U q12h and, most recently, 3 U glargine insulin q12h, without improvement of clinical signs. The cat also suffered from concurrent symmetrical bilateral alopecia of thorax and forelimbs, abdominal distension and lethargy. Hyperadrenocorticism (HAC), specifically pituitary-dependent HAC, was suspected and confirmed through abdominal ultrasonography demonstrating bilateral adrenal enlargement, and a low-dose dexamethasone suppression test using 0.1 mg/kg dexamethasone intravenously. Trilostane treatment (initially 10 mg/cat PO q24h then increased to 10 mg/cat PO q12h) was started and insulin sensitivity gradually improved, ultimately leading to diabetic remission after an increased in trilostane dose to 13mg/cat PO q12h, 14 months after the DM diagnosis and 7 months after the initiation of trilostane therapy.}, doi = {10.1177/2055116918767708}, issue = {1}, journal = {Journal of Feline Medicine and Surgery Open Reports}, publicationstatus = {Published}, publisher = {SAGE Publications}, url = {https://rvc-repository.worktribe.com/output/1387663}, volume = {4}, keyword = {ePrints migration}, year = {2018}, author = {Muschner, A C and Varela, F V and Hazuchova, K and Niessen, S J M} }