@article { , title = {Vitamin K catabolite inhibition of ovariectomy-induced bone loss: Structure–activity relationship considerations}, abstract = {The potential benefit of vitamin K as a therapeutic in osteoporosis is controversial and the vitamin K regimen being used clinically (45 mg/day) employs doses that are many times higher than required to ensure maximal gamma‐carboxylation of the vitamin K‐dependent bone proteins. We therefore tested the hypothesis that vitamin K catabolites, 5‐carbon (CAN5C) and 7‐carbon carboxylic acid (CAN7C) aliphatic side‐chain derivatives of the naphthoquinone moiety exert an osteotrophic role consistent with the treatment of osteoporosis.}, doi = {10.1002/mnfr.201400063}, issn = {1613-4125}, issue = {8}, journal = {Molecular Nutrition \& Food Research}, pages = {1658-1666}, publicationstatus = {Published}, publisher = {Wiley}, url = {https://rvc-repository.worktribe.com/output/1405225}, volume = {58}, keyword = {Musculoskeletal Biology, ePrints migration}, year = {2014}, author = {Soper, R J and Oguz, C and Emery, R and Pitsillides, A A and Hodges, S J} }