@article { , title = {Genomic analysis of the causative agents of coccidiosis in domestic chickens}, abstract = {Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.}, doi = {10.1101/gr.168955.113}, issn = {1088-9051}, issue = {10}, journal = {Genome Research}, pages = {1676-1685}, publicationstatus = {Published}, publisher = {Cold Spring Harbor Laboratory Press}, url = {https://rvc-repository.worktribe.com/output/1405241}, volume = {24}, keyword = {Integrated Research into Livestock and Food Systems, ePrints migration}, author = {Reid, A J and Blake, D P and Ansari, H R and Billington, K and Browne, H P and Bryant, J and Dunn, M and Hung, S S and Kawahara, F and Miranda-Saavedra, D and Malas, T B and Mourier, T and Naghra, H and Nair, M and Otto, T D and Rawlings, N D and Rivailler, P and Sanchez-Flores, A and Sanders, M and Subramaniam, C and Tay, Y-L and Woo, Y and Wu, X and Barrell, B and Dear, P H and Doerig, C and Gruber, A and Ivens, A C and Parkinson, J and Rajandream, M-A and Shirley, M W and Wan, K-L and Berriman, M and Tomley, F M and Pain, A} }