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Diabetes mellitus remission in a cat with pituitary-dependent hyperadrenocorticism after trilostane treatment

Muschner, A C; Varela, F V; Hazuchova, K; Niessen, S J M

Authors

A C Muschner

F V Varela

K Hazuchova

S J M Niessen



Abstract

An 8-year-old male neutered Persian cat was presented with polyuria, polydipsia, polyphagia and muscle weakness associated with a 7 month history of diabetes mellitus (DM). The cat had initially been treated with neutral protamine Hagedorn (NPH) insulin 2 U q12h, followed by porcine lente insulin 2 U q12h and, most recently, 3 U glargine insulin q12h, without improvement of clinical signs. The cat also suffered from concurrent symmetrical bilateral alopecia of thorax and forelimbs, abdominal distension and lethargy. Hyperadrenocorticism (HAC), specifically pituitary-dependent HAC, was suspected and confirmed through abdominal ultrasonography demonstrating bilateral adrenal enlargement, and a low-dose dexamethasone suppression test using 0.1 mg/kg dexamethasone intravenously. Trilostane treatment (initially 10 mg/cat PO q24h then increased to 10 mg/cat PO q12h) was started and insulin sensitivity gradually improved, ultimately leading to diabetic remission after an increased in trilostane dose to 13mg/cat PO q12h, 14 months after the DM diagnosis and 7 months after the initiation of trilostane therapy.

Citation

Muschner, A. C., Varela, F. V., Hazuchova, K., & Niessen, S. J. M. (2018). Diabetes mellitus remission in a cat with pituitary-dependent hyperadrenocorticism after trilostane treatment. Journal of Feline Medicine and Surgery Open Reports, 4(1), https://doi.org/10.1177/2055116918767708

Journal Article Type Other
Acceptance Date Feb 27, 2018
Publication Date Apr 16, 2018
Deposit Date May 1, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Feline Medicine and Surgery Open Reports
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 4
Issue 1
DOI https://doi.org/10.1177/2055116918767708
Public URL https://rvc-repository.worktribe.com/output/1387663

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