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Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study

Noyce, A J; Kia, D A; Hemani, G; Nicolas, A; Price, T R; De Pablo-Fernandez, E; Haycock, P C; Lewis, P A; Foltynie, T; Smith, G D; Schrag, A; Lees, A J; Hardy, J; Singleton, A; Nalls, M A; Pearce, N; Lawlor, D A; Wood, N W

Authors

A J Noyce

D A Kia

G Hemani

A Nicolas

T R Price

E De Pablo-Fernandez

P C Haycock

P A Lewis

T Foltynie

G D Smith

A Schrag

A J Lees

J Hardy

A Singleton

M A Nalls

N Pearce

D A Lawlor

N W Wood



Abstract

Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse causation. To our knowledge, Mendelian randomisation (MR)—the use of genetic instrumental variables (IVs) to explore causal effects—has not previously been used to test the effect of BMI on PD.

Citation

Noyce, A. J., Kia, D. A., Hemani, G., Nicolas, A., Price, T. R., De Pablo-Fernandez, E., …Wood, N. W. (2017). Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Medicine, 14(6), https://doi.org/10.1371/journal.pmed.1002314

Journal Article Type Article
Acceptance Date May 4, 2017
Publication Date Jun 13, 2017
Deposit Date Feb 5, 2020
Publicly Available Date Mar 29, 2024
Journal PLOS Medicine
Print ISSN 1549-1277
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 14
Issue 6
DOI https://doi.org/10.1371/journal.pmed.1002314
Public URL https://rvc-repository.worktribe.com/output/1391557

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