A J Noyce
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
Noyce, A J; Kia, D A; Hemani, G; Nicolas, A; Price, T R; De Pablo-Fernandez, E; Haycock, P C; Lewis, P A; Foltynie, T; Smith, G D; Schrag, A; Lees, A J; Hardy, J; Singleton, A; Nalls, M A; Pearce, N; Lawlor, D A; Wood, N W
Authors
D A Kia
G Hemani
A Nicolas
T R Price
E De Pablo-Fernandez
P C Haycock
P A Lewis
T Foltynie
G D Smith
A Schrag
A J Lees
J Hardy
A Singleton
M A Nalls
N Pearce
D A Lawlor
N W Wood
Abstract
Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse causation. To our knowledge, Mendelian randomisation (MR)—the use of genetic instrumental variables (IVs) to explore causal effects—has not previously been used to test the effect of BMI on PD.
Citation
Noyce, A. J., Kia, D. A., Hemani, G., Nicolas, A., Price, T. R., De Pablo-Fernandez, E., …Wood, N. W. (2017). Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Medicine, 14(6), https://doi.org/10.1371/journal.pmed.1002314
Journal Article Type | Article |
---|---|
Acceptance Date | May 4, 2017 |
Publication Date | Jun 13, 2017 |
Deposit Date | Feb 5, 2020 |
Publicly Available Date | Mar 29, 2024 |
Journal | PLOS Medicine |
Print ISSN | 1549-1277 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 6 |
DOI | https://doi.org/10.1371/journal.pmed.1002314 |
Public URL | https://rvc-repository.worktribe.com/output/1391557 |
Files
12543_GOLD.pdf
(2.9 Mb)
PDF
You might also like
Lysosomal positioning regulates Rab10 phosphorylation at LRRK2 + lysosomes
(2022)
Journal Article
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins
(2022)
Journal Article
A step forward for LRRK2 inhibitors in Parkinson's disease
(2022)
Journal Article
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search