Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania

Cox, S E; Makani, J; Soka, D; Kija, E; Dominguez-Salas, P; Newton, C R; Birch, A A; Prentice, A M; Kirkham, F J

Abstract

Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co?inheritance in SCA of alpha?thalassaemia and glucose?6?phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of haptoglobin (HP) is unknown. We investigated the effect of co?inheritance of these polymorphisms on CBFv in 601 stroke?free Tanzanian SCA patients aged

Citation

Cox, S. E., Makani, J., Soka, D., Kija, E., Dominguez-Salas, P., Newton, C. R., …Kirkham, F. J. (2014). Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania. British Journal of Haematology, 165(5), 699-706. https://doi.org/10.1111/bjh.12791

• Journal Article Type: Article
• Acceptance Date: Jan 5, 2014
• Publication Date: Feb 21, 2014
• Deposit Date: Aug 20, 2015
• Publicly Available Date: Nov 21, 2020
• Journal: British Journal of Haematology
• Print ISSN: 0007-1048
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 165
• Issue: 5
• Pages: 699-706
• DOI: https://doi.org/10.1111/bjh.12791
• Public URL: https://rvc-repository.worktribe.com/output/1405950