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Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania

Cox, S E; Makani, J; Soka, D; Kija, E; Dominguez-Salas, P; Newton, C R; Birch, A A; Prentice, A M; Kirkham, F J

Authors

S E Cox

J Makani

D Soka

E Kija

P Dominguez-Salas

C R Newton

A A Birch

A M Prentice

F J Kirkham



Abstract

Transcranial Doppler ultrasonography measures cerebral blood flow velocity (CBFv) of basal intracranial vessels and is used clinically to detect stroke risk in children with sickle cell anaemia (SCA). Co‐inheritance in SCA of alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase (G6PD) polymorphisms is reported to associate with high CBFv and/or risk of stroke. The effect of a common functional polymorphism of haptoglobin (HP) is unknown. We investigated the effect of co‐inheritance of these polymorphisms on CBFv in 601 stroke‐free Tanzanian SCA patients aged

Citation

Cox, S. E., Makani, J., Soka, D., Kija, E., Dominguez-Salas, P., Newton, C. R., Birch, A. A., Prentice, A. M., & Kirkham, F. J. (2014). Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania. British Journal of Haematology, 165(5), 699-706. https://doi.org/10.1111/bjh.12791

Journal Article Type Article
Acceptance Date Jan 5, 2014
Publication Date Feb 21, 2014
Deposit Date Aug 20, 2015
Publicly Available Date Jan 23, 2019
Journal British Journal of Haematology
Print ISSN 0007-1048
Electronic ISSN 1365-2141
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 165
Issue 5
Pages 699-706
DOI https://doi.org/10.1111/bjh.12791
Public URL https://rvc-repository.worktribe.com/output/1405950

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