Fungal Rhinosinusitis in Cats in the United Kingdom: 34 Cases (2013-2022)

Russell, OL; Johnson, D; Allan, F; Prior, C; O'Connell, E; Henry, P; Thompson, D; Fawsitt, J; Morales, CG; Neale, V; Molina, ISG; Hall, H; Gostelow, R; Kortum, A

Abstract

Background Fungal rhinosinusitis in cats is an uncommon condition with sparse literature regarding the presentation, causative agents, diagnosis, treatment, and prognosis within the UK. Hypothesis/ObjectivesTo describe and report the presenting clinical signs, diagnostic imaging findings, treatment approach, and outcome of cats diagnosed with fungal rhinosinusitis in the UK. AnimalsThirty-four client-owned cats were diagnosed with fungal rhinosinusitis. Methods Retrospective multicenter observational study. Cases presenting at 10 UK referral centers between January 2013 and December 2022 were retrospectively recruited. Results Median duration of clinical signs was 3 months (0.5-42-months). The most common signs were sneezing (27/34, 79%) and nasal discharge (21/34, 62%). Turbinate lysis was present in 27/34 cases (79%) and always involved the caudal nasal cavity. Osteolysis of the frontal bone, orbit, or cribriform plate was observed in 16/34 cases (47%). At least two tests from fungal culture, panfungal PCR, and histopathology were performed in all cases, and in 8/34 cases (24%) only one was positive. The treatment approach varied, with debridement, topical clotrimazole, and systemic azole therapy used alone or in various combinations, and repeat treatment occurred in 9/34 cases (26%). Clinical remission > 90 days after treatment was found in 9/24 cases (38%), but case fatality rates were low, with 3/34 cases (9%) dying with clinical disease during available follow-up. Conclusions and Clinical Importance Fungal rhinosinusitis should be considered in cats of any age with clinical signs of nasal disease. The prognosis from this data appears guarded for cats with fungal rhinosinusitis, with less than 50% of cats achieving long-term clinical remission.

Citation

Russell, O., Johnson, D., Allan, F., Prior, C., O'Connell, E., Henry, P., Thompson, D., Fawsitt, J., Morales, C., Neale, V., Molina, I., Hall, H., Gostelow, R., & Kortum, A. (2025). Fungal Rhinosinusitis in Cats in the United Kingdom: 34 Cases (2013-2022). Journal of Veterinary Internal Medicine, 39(3), https://doi.org/10.1111/jvim.70076

• Journal Article Type: Article
• Acceptance Date: Mar 11, 2025
• Online Publication Date: Mar 28, 2025
• Publication Date: 2025
• Deposit Date: May 12, 2025
• Publicly Available Date: May 12, 2025
• Print ISSN: 0891-6640
• Electronic ISSN: 1939-1676
• Publisher: Wiley Open Access
• Peer Reviewed: Peer Reviewed
• Volume: 39
• Issue: 3
• DOI: https://doi.org/10.1111/jvim.70076
• Keywords: aspergillus; cryptococcus; nasal; rhinitis; sinusitis; SINUSITIS; RHINITIS; CRYPTOCOCCOSIS; ASPERGILLOSIS