All Outputs (4)

Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes (2025)
Journal Article
Cava-Cami, B., Galvao, A., Van Ranst, H., Stocker, W., Harrison, C., Smitz, J., De Vos, M., Kelsey, G., & Anckaert, E. (2025). Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes. Molecular Human Reproduction, 31(1), https://doi.org/10.1093/molehr/gaaf001

Biphasic IVM can be offered as a patient-friendly alternative to conventional ovarian stimulation in IVF patients predicted to be hyper-responsive to ovarian stimulation. However, cumulative live birth rates after IVM per cycle are lower than after c... Read More about Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomes.

Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells (2024)
Journal Article
Wolodko, K., Sentjurc, T., Walewska, E., Laniecka, E., Jura, M., & Galvao, A. (2025). Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells. Molecular Metabolism, 91, https://doi.org/10.1016/j.molmet.2024.102062

Objectives Susceptibility to obesity in humans is driven by the intricate interplay of genetic, environmental and behavioural factors. Moreover, the mechanisms linking maternal obesity to infertility remain largely understudied. In this study, we inv... Read More about Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells.

Fetal growth restriction and placental defects in obese mice are associated with impaired decidualisation: the role of increased leptin signalling modulators SOCS3 and PTPN2 (2024)
Journal Article
Walewska, E., Makowczenko, K., Witek, K., Laniecka, E., Molcan, T., Alvarez-Sanchez, A., Kelsey, G., Perez-Garcia, V., & Galvao, A. (2024). Fetal growth restriction and placental defects in obese mice are associated with impaired decidualisation: the role of increased leptin signalling modulators SOCS3 and PTPN2. Cellular and Molecular Life Sciences, 81(1), https://doi.org/10.1007/s00018-024-05336-7

Decidualisation of the endometrium is a key event in early pregnancy, which enables embryo implantation. Importantly, the molecular processes impairing decidualisation in obese mothers are yet to be characterised. We hypothesise that impaired decidua... Read More about Fetal growth restriction and placental defects in obese mice are associated with impaired decidualisation: the role of increased leptin signalling modulators SOCS3 and PTPN2.

Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth (2024)
Journal Article
Latorraca, L., Galvao, A., Rabaglino, M., D'Augero, J., Kelsey, G., & Fair, T. (2024). Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth. BMC Genomics, 25(1), https://doi.org/10.1186/s12864-024-10234-0

Background Mammalian follicle development is characterized by extensive changes in morphology, endocrine responsiveness, and function, providing the optimum environment for oocyte growth, development, and resumption of meiosis. In cattle, the first s... Read More about Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth.