All Outputs (25)

MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells (2023)
Journal Article
Reid, K. M., Sanchez-Nieto, J. M., Terrasse, S., Faccenda, D., Pernaute, B., Campanella, M., …Cobb, B. S. (2023). MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells. Cells, 12(15), 1957. https://doi.org/10.3390/cells12151957

MicroRNAs (miRNAs) are important regulators of embryonic stem cell (ESC) biology, and their study has identified key regulatory mechanisms. To find novel pathways regulated by miRNAs in ESCs, we undertook a bioinformatics analysis of gene pathways di... Read More about MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells.

Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells (2016)
Journal Article
Zhang, S., Al-Maghout, T., Zhou, Y., Bissinger, R., Abousaab, A., Salker, M. S., …Lang, F. (2016). Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells. https://doi.org/10.1159/000447840

MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation (2016)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2016). MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation. Immunology, 149(1), 74-86. https://doi.org/10.1111/imm.12631

Transduction of helper T cells as a genetic approach to study mechanisms controlling their differentiation and function (2016)
Journal Article
Singh, Y., Lang, F., Garden, O. A., & Cobb, B. S. (2016). Transduction of helper T cells as a genetic approach to study mechanisms controlling their differentiation and function. Journal of Visualized Experiments, 117, https://doi.org/10.3791/54698

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR (2015)
Journal Article
Singh, Y., Garden, O. A., Lang, F., & Cobb, B. S. (2015). MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. Journal of Immunology, 195(12), 5667-5677. https://doi.org/10.4049/jimmunol.1401875

CD4(+) regulatory T cells (Tregs) are essential for controlling immune responses and preventing autoimmunity. Their development requires regulation of gene expression by microRNAs (miRNAs). To understand miRNA function in Treg development, we searche... Read More about MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Cohesins functionally associate with CTCF on mammalian chromosome arms
Journal Article
Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., …Merkenschlager, M. (in press). Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell, 132(3), 422-433. https://doi.org/10.1016/j.cell.2008.01.011

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Journal Article
Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., …Merkenschlager, M. (in press). T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. https://doi.org/10.1073/pnas.0800928105

A reappraisal of evidence for probabilistic models of allelic exclusion.
Journal Article
Taylor, B., Cobb, B. S., Bruno, L., Webste, Z., Fisher, A. G., & Merkenschlager, M. A reappraisal of evidence for probabilistic models of allelic exclusion. https://doi.org/10.1073/pnas.0808764105

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing
Journal Article
Redrup, L., Branco, M. R., Perdeaux, E. R., Krueger, C., Lewis, A., Santos, F., …Reik, W. The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development, 136(4), 525-30. https://doi.org/10.1242/dev.031328

IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1
Journal Article
Hadjur, S., Bruno, L., Hertweck, A., Cobb, B. S., Taylor, B., Fisher, A. G., & Merkenschlager, M. IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1. Immunology Letters, 122(1), 37-43. https://doi.org/10.1016/j.imlet.2008.11.001

Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
Journal Article
Hadjur, S., Williams, L., Ryan, N. K., Cobb, B. S., Sexton, T., Fraser, P., …Merkenschlager, M. (in press). Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature, 460(7253), 410-3. https://doi.org/10.1038/nature08079

Runx proteins regulate Foxp3 expression
Journal Article
Bruno, L., Mazzarella, L., Hoogenkamp, M., Hertweck, A., Cobb, B. S., Sauer, S., …Merkenschlager, M. (in press). Runx proteins regulate Foxp3 expression. Journal of Experimental Medicine, 206(11), 2329-37. https://doi.org/10.1084/jem.20090226

Small RNAs Control Sodium Channel Expression, Nociceptor Excitability, and Pain Thresholds
Journal Article
Zhao, J., Lee, M. C., Momin, A., Cendan, C. M., Shepherd, S. T., Baker, M. D., …Wood, J. N. Small RNAs Control Sodium Channel Expression, Nociceptor Excitability, and Pain Thresholds. Journal of Neuroscience, 30(32), 10860-10871. https://doi.org/10.1523/jneurosci.1980-10.2010

An Early Developmental Role for miRNAs in the Maintenance of Extraembryonic Stem Cells in the Mouse Embryo
Journal Article
Spruce, T., Pernaute, B., Di-Gregorio, A., Cobb, B. S., Merkenschlager, M., & Manzanares, M. An Early Developmental Role for miRNAs in the Maintenance of Extraembryonic Stem Cells in the Mouse Embryo. Developmental Cell, 19(2), 207-219. https://doi.org/10.1016/j.devcel.2010.07.014

MicroRNA miR-125a controls hematopoietic stem cell number
Journal Article
Guo, S., Lu, J., Schlanger, R., Zhang, H., Wang, J. Y., Fox, M. C., …Scadden, D. T. MicroRNA miR-125a controls hematopoietic stem cell number. https://doi.org/10.1073/pnas.0913574107

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B cell lineage specification and pre-B cell differentiation
Journal Article
Ferreirós-Vidal, I., Carroll, T., Taylor, B., Terry, A., Liang, Z., Bruno, L., …Merkenschlager, M. Genome-wide identification of Ikaros targets elucidates its contribution to mouse B cell lineage specification and pre-B cell differentiation. Blood, 121(10), 1769-82. https://doi.org/10.1182/blood-2012-08-450114

DIFFERENTIAL EXPRESSION OF THE TRANSCRIPTS ENCODING EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS LIGANDS BY CD4(+) T HELPER SUBSETS IN RESPONSE TO T CELL RECEPTOR ENGAGEMENT
Journal Article
Carney, K., Chan, W. Y., Singh, Y., Cobb, B. S., De Mestre, A. M., Affleck, K., & Garden, O. A. DIFFERENTIAL EXPRESSION OF THE TRANSCRIPTS ENCODING EPIDERMAL GROWTH FACTOR RECEPTOR AND ITS LIGANDS BY CD4(+) T HELPER SUBSETS IN RESPONSE TO T CELL RECEPTOR ENGAGEMENT. Immunology, 140, 145-145

VALIDATION OF TWO COMMERCIAL ANTIBODIES FOR THE DETECTION OF CANINE INTRACELLULAR IL-10
Journal Article
Wu, J., Carney, K., Singh, Y., Cobb, B. S., & Garden, O. A. VALIDATION OF TWO COMMERCIAL ANTIBODIES FOR THE DETECTION OF CANINE INTRACELLULAR IL-10. Immunology, 143, 91-91

DOWN-REGULATION OF MIR-22 AND MIR-26A INDEPENDENTLY INDUCES INSULIN RESISTANCE IN L6 MYOTUBES
Journal Article
Andersen, D. K., Cobb, B. S., & Cleasby, M. E. DOWN-REGULATION OF MIR-22 AND MIR-26A INDEPENDENTLY INDUCES INSULIN RESISTANCE IN L6 MYOTUBES. Diabetologia, 57, S97-S97

MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM
Journal Article
Pernaute, B., Spruce, T., Smith, K. M., Sanchez-Nieto, J. M., Manzanares, M., Cobb, B. S., & Rodriguez, T. A. (in press). MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM. https://doi.org/10.1101/gad.245621.114

Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regul... Read More about MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM.