Ethanol protects cultured neurons against amyloid-beta and alpha-synuclein-induced synapse damage
Journal Article
Bate, C., & Williams, A. Ethanol protects cultured neurons against amyloid-beta and alpha-synuclein-induced synapse damage. Neuropharmacology, 61(8), 1406-1412. https://doi.org/10.1016/j.neuropharm.2011.08.030
All Outputs (63)
Amyloid-beta-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins
Journal Article
Bate, C., & Williams, A. Amyloid-beta-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins. Journal of Biological Chemistry, 286(44), 37955-37963. https://doi.org/10.1074/jbc.M111.248724
Inhibition of phospholipase A(2) increased the removal of the prion derived peptide PrP82-146 from cultured neurons
Journal Article
Bate, C., Ingham, V., & Williams, A. Inhibition of phospholipase A(2) increased the removal of the prion derived peptide PrP82-146 from cultured neurons. Neuropharmacology, 60(2-3), 365-372. https://doi.org/10.1016/j.neuropharm.2010.10.001
Neurodegeneration Induced by Clustering of Sialylated Glycosylphosphatidylinositols of Prion Proteins
Journal Article
Bate, C., & Williams, A. Neurodegeneration Induced by Clustering of Sialylated Glycosylphosphatidylinositols of Prion Proteins. Journal of Biological Chemistry, 287(11), 7935-7944. https://doi.org/10.1074/jbc.M111.275743
Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42
Journal Article
Bate, C., Marshall, V., Colombo, L., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42. Neuropharmacology, 54(6), 934-943. https://doi.org/10.1016/j.neuropharm.2008.02.003Dietary supplements containing polyunsaturated fatty acids (PUFA) are frequently taken for their perceived health benefits including a possible reduction in cognitive decline in the elderly. Here we report that pre-treatment with docosahexaenoic acid... Read More about Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82-146 and A beta 1-42.
Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A(2) and synapse damage
Journal Article
Bate, C., & Williams, A. Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A(2) and synapse damage. Prion, 6(4), 350-353. https://doi.org/10.4161/pri.21751
The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication
Journal Article
Bate, C., Tayebi, M., & Williams, A. The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication. Biochemical Journal, 428, 95-101. https://doi.org/10.1042/bj20091469
Amyloid-beta(1-40) Inhibits Amyloid-beta(1-42) Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Degeneration
Journal Article
Bate, C., & Williams, A. Amyloid-beta(1-40) Inhibits Amyloid-beta(1-42) Induced Activation of Cytoplasmic Phospholipase A(2) and Synapse Degeneration. Journal of Alzheimer's Disease, 21(3), 985-993. https://doi.org/10.3233/jad-2010-100528
A Camelid Anti-PrP Antibody Abrogates PrPSc Replication in Prion-Permissive Neuroblastoma Cell Lines
Journal Article
Jones, D. R., Taylor, W. A., Bate, C., David, M., & Tayebi, M. A Camelid Anti-PrP Antibody Abrogates PrPSc Replication in Prion-Permissive Neuroblastoma Cell Lines. PLoS ONE, 5(3), https://doi.org/10.1371/journal.pone.0009804
Epitope-specific anti-prion antibodies upregulate apolipoprotein E and disrupt membrane cholesterol homeostasis
Journal Article
Tayebi, M., David, M., Bate, C., Jones, D. R., Taylor, W., Morton, R., Pollard, J., & Hawke, S. Epitope-specific anti-prion antibodies upregulate apolipoprotein E and disrupt membrane cholesterol homeostasis. Journal of General Virology, 91(Pt12), 3105-3115. https://doi.org/10.1099/vir.0.023838-0
PrP-specific camel antibodies with the ability to immunodetect intracellular prion protein
Journal Article
Tayebi, M., Taylor, W. A., Jones, D. R., Bate, C., & David, M. PrP-specific camel antibodies with the ability to immunodetect intracellular prion protein. Journal of General Virology, 91, 2121-2131. https://doi.org/10.1099/vir.0.018754-0
Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity. PLoS ONE, 4(12), e8221. https://doi.org/10.1371/journal.pone.0008221
LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
Presentation / Conference Contribution
Williams, A., & Bate, C. LIPID RAFTS, CELL SIGNALLING, PRION FORMATION AND NEURODEGENERATION IN PRION DISEASES
Do prion-induced changes in cholesterol trigger neurodegeneration?
Journal Article
Bate, C., & Williams, A. Do prion-induced changes in cholesterol trigger neurodegeneration?. Future Neurology, 3(4), 367-370. https://doi.org/10.2217/14796708.3.4.367
Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation
Journal Article
Bate, C., Tayebi, M., & Williams, A. Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-8Background: The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein ( PrPC) to an alternatively folded isoform ( PrPSc). The accumulation of PrPS... Read More about Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A(2) activation.
Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro
Journal Article
Bate, C., Tayebi, M., & Williams, A. Ginkgolides protect against amyloid-beta(1-42)-mediated synapse damage in vitro. Molecular Neurodegeneration, 3(1), https://doi.org/10.1186/1750-1326-3-1
Cholesterol esterification reduces the neurotoxicity of prions
Journal Article
Bate, C., Tayebi, M., & Williams, A. Cholesterol esterification reduces the neurotoxicity of prions. Neuropharmacology, 54(8), 1247-1253. https://doi.org/10.1016/j.neuropharm.2008.04.002The transmissible spongiform encephalopathies develop following the conversion of a host-encoded protein (PrPC) into abnormally folded, disease-related isoforms (PrPSc). Here we report that three acylcoenzyme A:cholesterol acyltransferase (ACAT) inhi... Read More about Cholesterol esterification reduces the neurotoxicity of prions.
Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells
Journal Article
Bate, C., Tayebi, M., Diomede, L., Salmona, M., & Williams, A. Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells. BMC Biology, 6, https://doi.org/10.1186/1741-7007-6-39Background: The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies suggest t... Read More about Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells.
Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions
Journal Article
Bate, C., & Williams, A. Role of glycosylphosphatidylinositols in the activation of phospholipase A(2) and the neurotoxicity of prions. Journal of General Virology, 85(85), 3797-3804. https://doi.org/10.1099/vir.0.80366-0
A role for B lymphocytes in anti-infective prion therapies?
Journal Article
Tayebi, M., Bate, C., Hawke, S., & Williams, A. A role for B lymphocytes in anti-infective prion therapies?. Expert Review of Anti-infective Therapy, 5(4), 631-638. https://doi.org/10.1586/14787210.5.4.631