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Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities (2020)
Journal Article
Blake, D. P., Worthing, K., & Jenkins, M. C. (2020). Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities. Genes, 11(9),

Eimeria, protozoan parasites from the phylum Apicomplexa, can cause the enteric disease coccidiosis in all farmed animals. Coccidiosis is commonly considered to be most significant in poultry; due in part to the vast number of chickens produced in th... Read More about Exploring Eimeria Genomes to Understand Population Biology: Recent Progress and Future Opportunities.

Re-calculating the cost of coccidiosis in chickens (2020)
Journal Article
Blake, D. P., Knox, J., Dehaeck, B., Huntington, B., Rathinam, T., Ravipati, V., Ayoade, S., Gilbert, W., Adebambo, A. O., Jatau, I. D., Raman, M., Parker, D., Rushton, J., & Tomley, F. M. (2020). Re-calculating the cost of coccidiosis in chickens. Veterinary Research, 51(1), https://doi.org/10.1186/s13567-020-00837-2

Coccidiosis, caused by Eimeria species parasites, has long been recognised as an economically significant disease of chickens. As the global chicken population continues to grow, and its contribution to food security intensifies, it is increasingly i... Read More about Re-calculating the cost of coccidiosis in chickens.

Phylogenetic inference using cytochrome c oxidase subunit I (COI) in the poultry red mite, Dermanyssus gallinae in the United Kingdom relative to a European framework (2020)
Journal Article
Karp-Tatham, E., Küster, T., Angelou, A., Papadopoulos, E., Nisbet, A., Xia, D., Blake, D., & Tomley, F. (2020). Phylogenetic inference using cytochrome c oxidase subunit I (COI) in the poultry red mite, Dermanyssus gallinae in the United Kingdom relative to a European framework. Frontiers in Veterinary Science,

The poultry red mite (Dermanyssus gallinae), an obligatory blood feeding ectoparasite, is primarily associated with laying hens where it is estimated to cause losses of ~€231 million per annum to European farmers. Moderate to high infestation levels... Read More about Phylogenetic inference using cytochrome c oxidase subunit I (COI) in the poultry red mite, Dermanyssus gallinae in the United Kingdom relative to a European framework.

Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis. (2020)
Journal Article
Pastor-Fernández, I., Sungwon, K., Marugán-Hernández, V., Soutter, F., Tomley, F., & Blake, D. (2020). Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis. Parasites and Vectors,

Poultry coccidiosis is a parasitic enteric disease with a highly negative impact on chicken production. In-feed chemoprophylaxis remains the primary method of control, but the increasing ineffectiveness of anticoccidial drugs, and potential future re... Read More about Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high level E. maxima challenge in a broiler model of coccidiosis..

Identification of Production Chain Risk Factors for Slaughterhouse Condemnation of Broiler Chickens’ (2020)
Journal Article
Buzdugan, S. N., Chang, Y. M., Huntington, B., Rushton, J., Guitian, J., Alarcon, P., & Blake, D. P. (2020). Identification of Production Chain Risk Factors for Slaughterhouse Condemnation of Broiler Chickens’. Preventive Veterinary Medicine, 105036. https://doi.org/10.1016/j.prevetmed.2020.105036

Slaughterhouse condemnation of broiler chickens results from identification of polymorphic pathological conditions during meat inspection from arrival and on theslaughter line. While conditions that result in condemnation are multifactorial, identifi... Read More about Identification of Production Chain Risk Factors for Slaughterhouse Condemnation of Broiler Chickens’.

Poultry Coccidiosis: Design and Interpretation of Vaccine Studies (2020)
Journal Article
Soutter, F., Werling, D., Tomley, F. M., & Blake, D. P. (2020). Poultry Coccidiosis: Design and Interpretation of Vaccine Studies. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00101

Eimeria infection impacts upon chicken welfare and economic productivity of the poultry sector. Live coccidiosis vaccines for chickens have been available for almost 70 years, but the requirement to formulate blends of oocysts from multiple Eimeria s... Read More about Poultry Coccidiosis: Design and Interpretation of Vaccine Studies.

Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice (2020)
Journal Article
Maharana, B. R., Sudhakar, N. R., Jawalagatti, V., Saravanan, B. C., Blake, D. P., & Tewari, A. K. (2020). Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice. Vaccines, 8(1), 84. https://doi.org/10.3390/vaccines8010084

Trypanosomosis, caused by Trypanosoma evansi, is an economically significant disease of livestock. Systematic antigenic variation by the parasite has undermined prospects for the development of a protective vaccine that targets the immunodominant sur... Read More about Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins of Trypanosoma evansi in Mice.

Effects of reducing growth rate via diet dilution on bone mineralization, performance and carcass yield of coccidia-infected broilers (2019)
Journal Article
Oikeh, I., Sakkas, P., Taylor, J., Giannenas, I., Blake, D. P., & Kyriazakis, I. (2019). Effects of reducing growth rate via diet dilution on bone mineralization, performance and carcass yield of coccidia-infected broilers. Poultry Science, 98(11), 5477-5487. https://doi.org/10.3382/ps/pez400

Coccidiosis and rapid growth rate (GR) compromise bone mineralization in modern broilers. We tested the hypothesis that reducing GR via diet dilution during peak bone development will improve bone mineralization in both infected and uninfected broile... Read More about Effects of reducing growth rate via diet dilution on bone mineralization, performance and carcass yield of coccidia-infected broilers.

Host transcriptome and microbiome interaction modulates physiology of full-sibs broilers with divergent feed conversion ratio (2019)
Journal Article
Shah, T. M., Patel, J. G., Gohil, T. P., Blake, D. P., & Joshi, C. G. (2019). Host transcriptome and microbiome interaction modulates physiology of full-sibs broilers with divergent feed conversion ratio. npj Biofilms and Microbiomes, https://doi.org/10.1038/s41522-019-0096-3

Efficient livestock production relies on effective conversion of feed into body weight gain (BWG). High levels of feed conversion are especially important in production of broiler chickens, birds reared for meat, where economic margins are tight. Tra... Read More about Host transcriptome and microbiome interaction modulates physiology of full-sibs broilers with divergent feed conversion ratio.

Identification and geographical distribution of pyrethroid resistance mutations in the poultry red mite Dermanyssus gallinae (2019)
Journal Article
Katsavou, E., Vlogiannitis, S., Karp-Tatham, E., Blake, D. P., Ilias, A., Strube, C., Kioulos, I., Dermauw, W., Van Leeuwen, T., & Vontas, J. (2019). Identification and geographical distribution of pyrethroid resistance mutations in the poultry red mite Dermanyssus gallinae. Pest Management Science, https://doi.org/10.1002/ps.5582

The poultry red mite (PRM) Dermanyssus gallinae is the most common ectoparasite on poultry and causes high economic losses in poultry farming worldwide. Pyrethroid acaricides have been widely used for its control and, consequently, pyrethroid resista... Read More about Identification and geographical distribution of pyrethroid resistance mutations in the poultry red mite Dermanyssus gallinae.

A Cryptosporidium parvum genotype shift between week old and two week old calves following administration of a prophylactic antiprotozoal (2019)
Journal Article
Seale, J., Swain, J., Booth, R. E., & Blake, D. P. (2019). A Cryptosporidium parvum genotype shift between week old and two week old calves following administration of a prophylactic antiprotozoal. Veterinary Parasitology, 273, 32-35. https://doi.org/10.1016/j.vetpar.2019.07.009

This study looked to assess the stability of Cryptosporidium parvum genotypes in calves between the final day of treatment with the antiprotozoal halofuginone lactate and seven days post-treatment. Paired faecal samples were collected on the final da... Read More about A Cryptosporidium parvum genotype shift between week old and two week old calves following administration of a prophylactic antiprotozoal.

Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens (2019)
Journal Article
Price, D. R. G., Küster, T., Øines, Ø., Margaret Oliver, E., Bartley, K., Nunn, F., Barbero, J. F. L., Pritchard, J., Karp-Tatham, E., Hauge, H., Blake, D. P., Tomley, F. M., & Nisbet, A. J. (2019). Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens. Avian Pathology, 48, S60-S74. https://doi.org/10.1080/03079457.2019.1612514

Dermanyssus gallinae, the poultry red mite, is a global threat to the commercial egg-laying industry. Control of D. gallinae is difficult, with only a limited number of effective pesticides and non-chemical treatments available. Here we characterise... Read More about Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens.

The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan (2019)
Journal Article
Neves, M. I., Malkawi, I., Walker, M., Alaboudi, A., Abu-Basha, E., Blake, D. P., Guitian, J., & Crotta, M. (2019). The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan. Epidemiology and Infection, 147, E134. https://doi.org/10.1017/S0950268818003308

Campylobacter is the leading cause of foodborne bacterial gastroenteritis in humans worldwide, often associated with the consumption of undercooked poultry. In Jordan, the majority of broiler chicken production occurs in semi-commercial farms, where... Read More about The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan.

Impact of Eimeria tenella coinfection on Campylobacter jejuni colonisation of the chicken (2019)
Journal Article
Macdonald, S. E., Van Diemen, P. M., Martineau, H., Stevens, M. P., Tomley, F. M., Stabler, R. A., & Blake, D. P. (2019). Impact of Eimeria tenella coinfection on Campylobacter jejuni colonisation of the chicken. Infection and Immunity, 87(2), https://doi.org/10.1128/IAI.00772-18

Eimeria tenella can cause the disease coccidiosis in chickens. The direct and often detrimental impact of this parasite on chicken health, welfare and productivity is well recognised, however less is known about the secondary effects infection may ha... Read More about Impact of Eimeria tenella coinfection on Campylobacter jejuni colonisation of the chicken.

Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken (2018)
Journal Article
Boulton, K., Nolan, M. J., Wu, Z., Riggio, V., Matika, O., Harman, K., Hocking, P. M., Bumstead, N., Hesketh, P., Archer, A., Bishop, S. C., Kaiser, P., Tomley, F. M., Hume, D. A., Smith, A. L., Blake, D. P., & Psifidi, A. (2018). Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken. Frontiers in Genetics, 9, https://doi.org/10.3389/fgene.2018.00528

Coccidiosis in poultry, caused by protozoan parasites of the genus Eimeria, is an intestinal disease with substantial economic impact. With the use of anticoccidial drugs under public and political pressure, and the comparatively higher cost of live-... Read More about Dissecting the Genomic Architecture of Resistance to Eimeria maxima Parasitism in the Chicken.

Draft genome assembly of the poultry red mite, Dermanyssus gallinae (2018)
Journal Article
Burgess, S. T. G., Bartley, K., Nunn, F., Wright, H. W., Hughes, M., Gemmell, M., Haldenby, S., Paterson, S., Rombauts, S., Tomley, F. M., Blake, D. P., Pritchard, J., Schicht, S., Strube, C., Øines, Ø., Van Leeuwen, T., Van De Peer, Y., & Nisbet, A. J. (2018). Draft genome assembly of the poultry red mite, Dermanyssus gallinae. Microbiology Resource Announcements, 7(18), https://doi.org/10.1128/MRA.01221-18

The poultry red mite, Dermanyssus gallinae, is a major worldwide concern in the egg-laying industry. Here, we report the first draft genome assembly and gene prediction of Dermanyssus gallinae, based on combined PacBio and MinION long-read de novo se... Read More about Draft genome assembly of the poultry red mite, Dermanyssus gallinae.

Genetic diversity and population structure of Angiostrongylus vasorum parasites within and between local urban foxes (Vulpes Vulpes) (2018)
Journal Article
Blanch-Lazaro, B., Mitton, Z., Tudor, C., Hindle, J., Martineau, H., Fox, M. T., & Blake, D. P. (2018). Genetic diversity and population structure of Angiostrongylus vasorum parasites within and between local urban foxes (Vulpes Vulpes). Veterinary Parasitology, 262, 42-46. https://doi.org/10.1016/j.vetpar.2018.09.008

Angiostrongylus vasorum is a nematode parasite of the pulmonary arteries and heart that infects domestic and wild canids. Dogs (Canis familiaris) and red foxes (Vulpes vulpes) are the most commonly affected definitive hosts. Recent studies suggest th... Read More about Genetic diversity and population structure of Angiostrongylus vasorum parasites within and between local urban foxes (Vulpes Vulpes).

Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions (2018)
Journal Article
Hoelzer, K., Bielke, L., Blake, D. P., Cox, E., Cutting, S. M., Devriendt, B., Erlacher-Vindel, E., Goossens, E., Karaca, K., Lemiere, S., Metzner, M., Raicek, M., Collell Suriñach, M., Wong, N. M., Gay, C., & Van Immerseel, F. (2018). Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions. BMC Veterinary Research, 49(70), https://doi.org/10.1186/s13567-018-0561-7

Vaccines and other alternative products are central to the future success of animal agriculture because they can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations. To assess scientific adva... Read More about Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions.