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All Outputs (6)

A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats (2021)
Journal Article
Catchpole, B., Forcada, Y., Boursnell, M., & Church, D. (2021). A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats. PLoS ONE, https://doi.org/10.1371/journal.pone.0259939

Diabetes mellitus (DM) is a common feline endocrinopathy, which is similar to human type 2 diabetes (T2DM) in terms of its pathophysiology. T2DM occurs due to peripheral insulin resistance and/or β-cell dysfunction. Several studies have identified ge... Read More about A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats.

Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK (2021)
Journal Article
Pegram, C., Raffan, E., White, E., Ashworth, A., Brodbelt, D., Church, D., & O'Neill, D. (2021). Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13325

Objectives: To evaluate the prevalence and risk factors for overweight status in dogs under primary veterinary care in the UK.
Methods: A retrospective study design was used to estimate the one-year (2016) period prevalence of overweight status. The... Read More about Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK.

Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors (2021)
Journal Article
Mirczuk, S., Scudder, C., Read, J., Crossley, V., Regan, J., Richardson, K., Simbi, B., Mcardle, C., Church, D., Fenn, J., Kenny, P., Volk, H., Wheeler-Jones, C., Korbonits, M., Niessen, S., Mcgonnell, I., & Fowkes, R. (2021). Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors. International Journal of Molecular Sciences, -. https://doi.org/10.3390/ijms22031076

Patients harbouring mutations in genes encoding C-type natriuretic peptide (CNP; NPPC) or its receptor guanylyl cyclase B (GC-B, NPR2) suffer from severe growth phenotypes; loss-of-function mutations cause achondroplasia, whereas gain-of-function mut... Read More about Natriuretic peptide expression and function in GH3 somatolactotropes and feline somatotrope pituitary tumors.