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All Outputs (4)

A review of the equine suspensory ligament: Injury prone yet understudied (2024)
Journal Article
Guest, D. J., Birch, H. L., & Thorpe, C. T. (2024). A review of the equine suspensory ligament: Injury prone yet understudied. Equine Veterinary Journal, 1-16. https://doi.org/10.1111/evj.14447

The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the ener... Read More about A review of the equine suspensory ligament: Injury prone yet understudied.

Regenerative Medicine and Biological Treatments (2024)
Book Chapter
Guest, D., Schramme, M., & Smith, R. (2024). Regenerative Medicine and Biological Treatments. In Essential Facts of Equine Physical Therapy, Rehabilitation and Sports Medicine

Many tissues undergo poor natural regeneration following injury or disease and the reparative healing process can lead to tissues that are functionally inferior and prone to re-injury. Regenerative medicine aims to induce natural tissue regeneration... Read More about Regenerative Medicine and Biological Treatments.

Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes (2024)
Journal Article
Smith, E. J., Beaumont, R. E., Dudhia, J., & Guest, D. J. (in press). Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-024-10693-8

Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contribut... Read More about Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.