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A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappa B activation of Theileria parva-transformed B cells
Journal Article
Guergnon, J., Chaussepied, M., Sopp, P., Lizundia, R., Moreau, M. F., Blumen, B., Werling, D., Howard, C. J., & Langsley, G. A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappa B activation of Theileria parva-transformed B cells. Cellular Microbiology, 5(10), 709-716. https://doi.org/10.1046/j.1462-5822.2003.00314.x

Identification and functional characterization of a bovine orthologue to DC-SIGN
Journal Article
Yamakawa, Y., Pennelegion, C., Willcocks, S., Stalker, A., MacHugh, N., Burt, D., Coffey, T. J., & Werling, D. Identification and functional characterization of a bovine orthologue to DC-SIGN. Journal of Leukocyte Biology, 83(6), 1396-1403. https://doi.org/10.1189/jlb.0807523

Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) C-type lectin is almost exclusively expressed at the cell surface of DC. In addition to its normal function facilitating contact of DC with T cells, DC-SIGN has been shown to bind a variet... Read More about Identification and functional characterization of a bovine orthologue to DC-SIGN.

Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance
Journal Article
Jann, O. C., Werling, D., Chang, J. S., Haig, D., & Glass, E. J. Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance. BMC Evolutionary Biology, 8(288), https://doi.org/10.1186/1471-2148-8-288

Background: There is accumulating evidence that polymorphism in Toll-like receptor (TLR) genes might be associated with disease resistance or susceptibility traits in livestock. Polymorphic sites affecting TLR function should exhibit signatures of po... Read More about Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance.

Host species-specific usage of the TLR4-LPS receptor complex
Journal Article
Lizundia, R., Sauter, K. S., Taylor, G., & Werling, D. Host species-specific usage of the TLR4-LPS receptor complex. Innate Immunity, 14(4), 223-231. https://doi.org/10.1177/1753425908095957

Recognition of LIPS depends on the interaction of at least three molecules forming the LPS-receptor complex. The Most important ones, CD14. MD2 and Toll-like receptor (TLR) 4 share a high degree of homology between species. In the present study, we i... Read More about Host species-specific usage of the TLR4-LPS receptor complex.

Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)
Journal Article
Vats, A., Gautam, D., Maharana, J., Chera, J. S., Kumar, S., Werling, D., & De, S. (in press). Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis). Molecular Immunology, 121, 136-143. https://doi.org/10.1016/j.molimm.2020.03.004

The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well... Read More about Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis).

Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis)
Journal Article
Vats, A., Gautam, D., Maharana, J., Singh Chera, J., Kumar, S., Rout, P. K., Werling, D., & De, S. Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis). Molecular Immunology, 121, 136-143

The innate immune system is activated upon virus invasion of a host cell by recognizing viral component, such as dsRNA through specific receptors, resulting in the production of type- I IFNs, which confer an antiviral state within the invaded as well... Read More about Poly I:C stimulation in-vitro as a marker for an antiviral response in different cell types generated from Buffalo (Bubalus bubalis).

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
Journal Article
Dutton, L. C., Dudhia, J., Catchpole, B., Hodhkiss-Geere, H., Werling, D., & Connolly, D. J. (in press). Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor. https://doi.org/10.1038/s41598-018-31569-1

derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focusse... Read More about Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor.

Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells
Journal Article
Jensen, K., Gallagher, I. J., Kaliszewska, A., Zhang, C., Abejide, O., Gallagher, M. P., Werling, D., & Glass, E. J. (in press). Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells. Veterinary Research, 47(46), https://doi.org/10.1186/s13567-016-0328-y

Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils
Journal Article
Conejeros, I., Gibson, A. J., Werling, D., Munoz-Caro, T., Hermosilla, C., Taubert, A., & Burgos, R. A. (in press). Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils. Developmental and Comparative Immunology, 52(2), 215-225. https://doi.org/10.1016/j.dci.2015.05.012

Toll-like receptors (TLR) are a family of pattern recognition receptors that sense microbial associated molecular patterns (MAMP) such as microbial membrane components and nucleic acids of bacterial origin. Polymorphonuclear neutrophils (PMN) are the... Read More about Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils.

Effects of Ex-Vivo and In-Vivo Treatment with Probiotics on the Inflammasome in Dogs with Chronic Enteropathy
Journal Article
Schmitz, S., Werling, D., & Allenspach, K. (in press). Effects of Ex-Vivo and In-Vivo Treatment with Probiotics on the Inflammasome in Dogs with Chronic Enteropathy. PLoS ONE, 10(3), e0120779. https://doi.org/10.1371/journal.pone.0120779

Inflammasomes coordinate the maturation of IL-1β and IL-18 in response to danger signals. They are vital for maintenance of intestinal homeostasis and have been linked to chronic intestinal inflammation in humans. Probiotics have been advocated as tr... Read More about Effects of Ex-Vivo and In-Vivo Treatment with Probiotics on the Inflammasome in Dogs with Chronic Enteropathy.

Lack of Correlation between Mucosal Immunoglobulin A-positive Plasma Cell Numbers and TLR5 Genotypes in German Shepherd Dogs with Idiopathic Chronic Enteropathy
Journal Article
Lee, A., Kathrani, A., Priestnall, S. L., Smith, K. C., Werling, D., & Allenspach, K. (in press). Lack of Correlation between Mucosal Immunoglobulin A-positive Plasma Cell Numbers and TLR5 Genotypes in German Shepherd Dogs with Idiopathic Chronic Enteropathy. Journal of Comparative Pathology, 152(2-3), 201-5. https://doi.org/10.1016/j.jcpa.2015.01.002