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All Outputs (10)

Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review (2022)
Journal Article
Hellewell, L., Gilani, N., Stanton, C., Pelligand, L., Franzyk, H., Guardabassi, L., & Good, L. (in press). Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review. Future Medicinal Chemistry, https://doi.org/10.4155/fmc-2022-0160

Aims: This systematic review was carried out to determine whether synthetic peptidomimetics exhibit significant advantages over antimicrobial peptides (AMPs) in terms of in vitro potency. Structural features - molecular weight, charge and length - we... Read More about Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review.

Antibiotic usage practices and its drivers in commercial chicken production in Bangladesh (2022)
Journal Article
Chowdhury, S., Fournié, G., Blake, D., Henning, J., Conway, P., Hoque, M. A., …Chowdhury, F. (2022). Antibiotic usage practices and its drivers in commercial chicken production in Bangladesh. PLoS ONE, 17(10), e0276158. https://doi.org/10.1371/journal.pone.0276158

Irrational and inappropriate use of antibiotics in commercial chicken production can contribute to the development of antimicrobial resistance. We aimed to assess antibiotic usage in commercial chicken production in Bangladesh, and identify factors a... Read More about Antibiotic usage practices and its drivers in commercial chicken production in Bangladesh.

Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations (2022)
Journal Article
Kuroda, T., Minamijima, Y., Mita, H., Tamura, N., Fukuda, K., Kuwano, A., …Sato, F. (2022). Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13099

A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration of CEZ in horses. Seven horses received a single IM or intravenous (IV) administ... Read More about Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.

Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma (2022)
Journal Article
Azzariti, S., Bond, R., Loeffler, A., Zendri, F., Timofte, D., Chang, Y., & Pelligand, L. (2022). Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma. Antibiotics, https://doi.org/10.3390/antibiotics11091204

Fluoroquinolones (FQ) are commonly used in dogs with bacterial skin infections. Their use as first choice, along with the increased incidence of FQ-resistance, represents a risk to animal and public health. Our study determined minimum inhibitory (M... Read More about Investigation of in vitro susceptibility and resistance mechanisms in skin pathogens: perspectives for fluoroquinolone therapy in canine pyoderma.

Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves (2022)
Journal Article
Mead, A., Toutain, P., Richez, P., & Pelligand, L. (2022). Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/aac.00793-22

Heteroresistance correspond to the presence in a bacterial isolate of an initial small subpopulation of bacteria characterized by a significant reduction in their sensitivity to a given antibiotic. Mechanisms of heteroresistance vs. resistance are po... Read More about Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves.

Supplementary Data: Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves (2022)
Dataset
Mead, A., Toutain, P., Richez, P., & Pelligand, L. Supplementary Data: Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves. [Dataset]

Data for: Quantitative pharmacodynamic characterization of resistance vs. heteroresistance of colistin in E. coli using a semi-mechanistic modelling of killing curves

Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study (2022)
Journal Article
Henze, L., Foth, S., Meller, S., Twele, F., Charalambous, M., Kenward, H., …Volk, H. (2022). Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16504

Background: Nausea and emesis can be, among other signs, common manifestations of acute vestibular system dysfunction in dogs. Currently, antiemetic drugs, such as maropitant and metoclopramide, are used commonly, but do not appear to control naus... Read More about Ondansetron in dogs with nausea associated with vestibular disease: A double-blinded, randomized placebo-controlled crossover study.

Epidemiological prevalence of phenotypical resistances and mobilised colistin resistance in avian commensal and pathogenic E. coli from Denmark, France, Netherlands and UK (2022)
Journal Article
Mead, A., Billon-Lotz, C., Olsen, R., Swift, B., Richez, P., Stabler, R., & Pelligand, L. (2022). Epidemiological prevalence of phenotypical resistances and mobilised colistin resistance in avian commensal and pathogenic E. coli from Denmark, France, Netherlands and UK. Antibiotics, https://doi.org/10.3390/antibiotics11050631

Colistin has been used for treatment of non-invasive gastrointestinal infections caused by avian pathogenic E. coli (APEC). The discovery of mobilised colistin resistance (mcr) in E. coli [1] has instigated a One Health approach to minimise colistin... Read More about Epidemiological prevalence of phenotypical resistances and mobilised colistin resistance in avian commensal and pathogenic E. coli from Denmark, France, Netherlands and UK.

Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib (2022)
Journal Article
Lees, P., Toutain, P., Elliott, J., Giraudel, J. M., Pelligand, L., & King, J. N. (2022). Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib. Journal of Veterinary Pharmacology and Therapeutics, 45(4), 325-351. https://doi.org/10.1111/jvp.13052

Robenacoxib is a veterinary-approved non-steroidal anti-inflammatory drug (NSAID) of the coxib group. It possesses anti-hyperalgesic, anti-inflammatory and anti-pyretic properties. Robenacoxib inhibits the cyclooxygenase (COX)-2 isoform of COX select... Read More about Pharmacology, safety, efficacy and clinical uses of the COX‐2 inhibitor robenacoxib.