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Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli (2021)
Journal Article
Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.698135

Colistin, a last-line antibiotic of major importance in veterinary medicine and of critical importance in human medicine, is authorized to treat gastrointestinal (enteric) infections caused by non-invasive Escherichia coli in multiple veterinary spec... Read More about Pharmacokinetics of Colistin in the Gastrointestinal Tract of Poultry Following Dosing via Drinking Water and Its Bactericidal Impact on Enteric Escherichia coli.

Effect of theatre temperature on body temperature during anaesthesia for routine neutering of domestic rabbits (Oryctolagus cuniculus) (2021)
Journal Article
Edis, A., Pelligand, L., Baldrey, V., & Hedley, J. (2022). Effect of theatre temperature on body temperature during anaesthesia for routine neutering of domestic rabbits (Oryctolagus cuniculus). Veterinary Anaesthesia and Analgesia, 49(2), 173-181. https://doi.org/10.1016/j.vaa.2021.06.019

Objective: To investigate the effect of theatre temperature on body temperature in rabbits undergoing castration or ovariohysterectomy surgery during general anaesthesia. Study design: Prospective, clinical study. Animals: A group of 88 rabbits... Read More about Effect of theatre temperature on body temperature during anaesthesia for routine neutering of domestic rabbits (Oryctolagus cuniculus).

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs (2021)
Journal Article
Vegas Cómitre, M., Cortellini, S., Devreese, M., Roques, B., Bousquet-Melou, A., Toutain, P., & Pelligand, L. (2021). Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs. Journal of Veterinary Medicine, https://doi.org/10.3389/fvets.2021.770202

Background – Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs is lacking and likely differs from healthy dogs. Hypothesis/Objectives —To describe a population PK model for intravenous amoxicillin clavulanic acid (AMC) in... Read More about Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs.

Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry (2021)
Journal Article
Mead, A., Gillard, N., Robert, C., Richez, P., Pierret, G., Henrottin, J., & Pelligand, L. (2021). Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13022

Justification for continued use of colistin in veterinary medicine, e.g. medicated water, relies on pharmacokinetic/pharmacodynamic (PK/PD) studies that require accurate measurement of colistin content in the digestive tract. A method for the detect... Read More about Determination of colistin in luminal and parietal intestinal matrices of chicken by ultra-high performance liquid chromatography-tandem mass spectrometry.

Pharmacokinetics of colistin in the gastrointestinal tract of poultry following dosing via drinking water, and the bactericidal impact on enteric E. coli. (2021)
Journal Article
Mead, A., Richez, P., Azzariti, S., & Pelligand, L. (2021). Pharmacokinetics of colistin in the gastrointestinal tract of poultry following dosing via drinking water, and the bactericidal impact on enteric E. coli. Frontiers in Veterinary Science,

Colistin, a last line antibiotic of major importance in veterinary medicine and critical importance in human medicine, is authorised to treat gastrointestinal (enteric) infections caused by non-invasive E. coli in multiple veterinary species includin... Read More about Pharmacokinetics of colistin in the gastrointestinal tract of poultry following dosing via drinking water, and the bactericidal impact on enteric E. coli..

The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome (2021)
Journal Article
Foth, S., Meller, S., Kenward, H., Elliott, J., Pelligand, L., & Volk, H. (2021). The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome. BMC Veterinary Research, 17(1), https://doi.org/10.1186/s12917-021-02931-9

Background Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5-HT3 receptor antagonists to reduce nausea has been described for chemothe... Read More about The use of ondansetron for the treatment of nausea in dogs with vestibular syndrome.

A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients (2021)
Journal Article
Bousquet-Mélou, A., Lespine, A., Sutra, J., Bargues, I., & Toutain, P. (2021). A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients. Frontiers in Pharmacology, https://doi.org/10.3389/fphar.2021.666348

Ivermectin (IVM) and moxidectin (MOX) are used extensively as parasiticides in veterinary medicine. Based on in vitro data, IVM has recently been proposed for the prevention and treatment of COVID-19 infection, a condition for which obesity is a majo... Read More about A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients.

WSAVA Therapeutic Guidelines (2020)
Other
Steagall, P. V., Pelligand, L., Page, S. W., Bourgeois, M., Weese, S., Manigot, G., …Guardabassi, L. (2020). WSAVA Therapeutic Guidelines. Journal of Small Animal Practice

This list of essential medicines is presented by members of the WSAVA Therapeutic Guidelines Group (TGG) following extensive internal and external peer‐review. Internal peer‐review was provided by TGG members and its subcommittees, whereas external p... Read More about WSAVA Therapeutic Guidelines.

Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities (2020)
Journal Article
D'Anselme, O., Pelligand, L., Veres-Nyeki, K. O., Zaccagnini, A., & Zilberstein, L. (2020). Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities. Veterinary Anaesthesia and Analgesia,

Objectives: There are no standardized methods for teaching anaesthesia in veterinary universities. Our aims were 1) design a holistic audit tool to assess anaesthesia teaching strategies in veterinary universities; 2) to apply the tool to 4 veterina... Read More about Analysis of teaching methods in anaesthesia in the undergraduate curriculum of 4 veterinary universities.

Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs (2020)
Journal Article
Pelligand, L., Guillot, E., Geneteau, A., Guyonnet, J., Magnier, R., Elliott, J., …Jacobs, M. (2020). Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs. Frontiers in Veterinary Science, 7, https://doi.org/10.3389/fvets.2020.00151

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs rec... Read More about Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs.

A possible solution to model nonlinearity in elimination and distributional clearances with a2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses (2019)
Journal Article
Gozalo-Marcilla, M., Moreira Da Silva, R., Pacca Loureiro Luna, S., Rodrigues De Oliveira, A., Werneck Fonseca, M., Peporine Lopes, N., …Pelligand, L. (2019). A possible solution to model nonlinearity in elimination and distributional clearances with a2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12815

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses (2019)
Journal Article
Gozalo-Marcilla, M., Rodrigues De Oliveira, A., Werneck Fonseca, M., Possebon, F. S., Pelligand, L., Taylor, P. M., & Luna, S. P. L. (2019). Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses. Equine Veterinary Journal, 51(4), 530-536. https://doi.org/10.1111/evj.13054

VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle (2019)
Journal Article
Toutain, P., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle. Frontiers in Microbiology, 10(1310), https://doi.org/10.3389/fmicb.2019.01310

The PK/PD cut-off (PK/PDCO ) value of florfenicol for calf pathogens was determined for long acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of the three MICs considered by VetCAST, a sub-committee of the Europea... Read More about VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle.