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All Outputs (110)

Dogs attending primary-care practice in England with clinical signs suggestive of Chiari-like malformation/syringomyelia (2016)
Journal Article
Sanchis-Mora, S., Pelligand, L., Thomas, C. L., Volk, H. A., Abeyesinghe, S. M., Brodbelt, D. C., …O'Neill, D. G. (2016). Dogs attending primary-care practice in England with clinical signs suggestive of Chiari-like malformation/syringomyelia. Veterinary Record, 179(17), 436. https://doi.org/10.1136/vr.103651

Chiari-like malformation/syringomyelia (CM/SM) in dogs describes a developmental disorder that can cause pain and reduced quality of life. This retrospective study aimed to report the period prevalence, clinical signs and risk factors for diagnosis o... Read More about Dogs attending primary-care practice in England with clinical signs suggestive of Chiari-like malformation/syringomyelia.

Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats (2016)
Journal Article
Pelligand, L., Soubret, A., King, J. N., Elliott, J., & Mochel, J. P. (2016). Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. https://doi.org/10.1002/psp4.12141

The objective of this study was to model the pharmacokinetics (PKs) of robenacoxib in cats using a nonlinear mixed‐effects (NLME) approach, leveraging all available information collected from cats receiving robenacoxib s.c. and/or i.v.: 47 densely sa... Read More about Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats.

Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats (2016)
Journal Article
Bijsmans, E. S., Doig, M., Jepson, R. E., Syme, H. M., Elliott, J., & Pelligand, L. (2016). Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats. Journal of Veterinary Internal Medicine, 30(5), 1630-1636. https://doi.org/10.1111/jvim.14562

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney (2015)
Journal Article
Pelligand, L., Suemanotham, N., King, J. N., Seewald, W., Syme, H. M., Smith, K. C., …Elliott, J. (2015). Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney. BMC Veterinary Research, 11(296), https://doi.org/10.1186/s12917-015-0598-z

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration (2014)
Journal Article
Kenward, H., Pelligand, L., & Elliott, J. (2014). Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration. Experimental Brain Research, 232(8), 2685-2697. https://doi.org/10.1007/s00221-014-3961-6

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated... Read More about Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.

Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation (2014)
Journal Article
Pelligand, L., King, J. N., Hormazabal, V., Toutain, P. L., Elliott, J., & Lees, P. (2014). Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Journal of Veterinary Pharmacology and Therapeutics, 37(4), 354-366. https://doi.org/10.1111/jvp.12107

Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives. This study reports the pharmacokinetic/pharmacodynamic (PK/PD) mod... Read More about Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation.

Longitudinal left ventricular myocardial dysfunction assessed by 2D colour tissue Doppler imaging in a dog with systemic hypertension and severe arteriosclerosis
Journal Article
Nicolle, A. P., Sampedrano, C. C., Fontaine, J. J., Tessier-Vetzel, D., Goumi, V., Pelligand, L., …Chetboul, V. Longitudinal left ventricular myocardial dysfunction assessed by 2D colour tissue Doppler imaging in a dog with systemic hypertension and severe arteriosclerosis. https://doi.org/10.1111/j.1439-0442.2004.00688.x

Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK
Dataset
Elkholly, D. A., Brodbelt, D. C., Church, D. B., Pelligand, L., & O'Neill, D. G. Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK. [Dataset]

"Side effects for SGC_Cases and non-cases_Treatment_Demographics" is a random sample of 3000 dogs under primary veterinary care that had systemic glucocorticoid treatment in 2013, taken from the VetCompass dataset. The data provide the demographic ch... Read More about Side effects to systemic glucocorticoid therapy in dogs under primary veterinary care in the UK.

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics
Journal Article
Bon, C., Toutain, P. L., Concordet, D., Martin-Jimenez, T., Gehring, R., Smith, J., …Mochel, J. P. (2017). Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.12473