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Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites (2022)
Journal Article
Willen, L., Milton, P., Hamley, J., Walker, M., Osei-Atweneboana, M., Volf, P., …Courtenay, O. (2022). Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites. PLoS Neglected Tropical Diseases, 16(1), https://doi.org/10.1371/journal.pntd.0010108

BackgroundIn onchocerciasis endemic areas in Africa, heterogenous biting rates by blackfly vectors on humans are assumed to partially explain age- and sex-dependent infection patterns with Onchocerca volvulus. To underpin these assumptions and furthe... Read More about Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites.

Is the incidence of congenital toxoplasmosis declining? (2022)
Journal Article
Milne, G., Webster, J., & Walker, M. (2022). Is the incidence of congenital toxoplasmosis declining?. Trends in Parasitology, 39(1), 26-37. https://doi.org/10.1016/j.pt.2022.10.003

Prenatal infection with the protozoan parasite Toxoplasma gondii can cause con-genital toxoplasmosis (CT), an often fatal or lifelong-disabling condition. Several studies of human populations have reported temporal decreases in seroprevalence, sugges... Read More about Is the incidence of congenital toxoplasmosis declining?.

Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands (2022)
Journal Article
Pennance, T., Neves, M. I., Webster, B. L., Gower, C. M., Knopp, S., Khamis, I. S., …Webster, J. P. (2022). Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands. PLoS Neglected Tropical Diseases, 16(10), e0010419. https://doi.org/10.1371/journal.pntd.0010419

Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance (2022)
Journal Article
Díaz, A. V., Lambert, S., Neves, M. I., Borlase, A., Léger, E., Diouf, N. D., …Walker, M. (2022). Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance. Frontiers in Tropical Diseases, 3, 1-12. https://doi.org/10.3389/fitd.2022.893066

Schistosomiasis, a neglected tropical disease, is a widespread chronic helminthiasis reported in 78 countries, predominantly those within sub-Saharan Africa, as well as Latin America, Asia, and most recently, even Europe. Species of the causative blo... Read More about Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance.

Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis (2022)
Journal Article
Dixon, M., Winskill, P., Harrison, W., Whittaker, C., Schmidt, V., Sanchez, A., …Basanez, M. (2022). Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis. eLife, 11, https://doi.org/10.7554/eLife.76988

Infection by Taenia solium poses a major burden across endemic countries. The World Health Organization (WHO) 2021-2030 Neglected Tropical Diseases roadmap has proposed that 30% of endemic countries achieve intensified T. solium control in hyperendem... Read More about Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis.

Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data (2022)
Journal Article
Walker, M., Freitas, L. T., Halder, J. B., Brack, M., Keiser, J., King, C. H., …Basáñez, M. (in press). Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data. Wellcome Open Research, 7, 5. https://doi.org/10.12688/wellcomeopenres.17468.1

Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa (2021)
Book Chapter
Cheke, R., Little, K., Young, S., Walker, M., & Basanez, M. (2021). Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa. In R. Stothard, & D. Rollinson (Eds.), . https://doi.org/10.1016/bs.apar.2021.01.002

Onchocerciasis (also known as `river blindness'), is a neglected tropical disease (NTD) caused by the (Simulium-transmitted) filarial nematode Onchocerca volvulus. The occurrence of `blinding' (savannah) and non-blinding (forest) parasite strains and... Read More about Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa.

Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective (2021)
Journal Article
Diaz, A., Walker, M., & Webster, J. (2021). Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective. Evolutionary Applications, https://doi.org/10.1111/eva.13310

The relevance of mustelids in SARS-CoV-2 transmission has become increasingly evident. Alongside experimental demonstration of airborne transmission among ferrets, the major animal model for human respiratory diseases, transmission of SARS-CoV-2 with... Read More about Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective.

Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure (2021)
Journal Article
Walker, M., Cools, P., Albonico, M., Ame, S. M., Ayana, M., Dana, D., …Levecke, B. (in press). Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. PLoS Neglected Tropical Diseases, 15(10), e0009888. https://doi.org/10.1371/journal.pntd.0009888

Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends (2020)
Journal Article
Dixon, M. A., Winskill, P., Harrison, W. E., Whittaker, C., Schmidt, V., Sarti, E., …Basáñez, M. G. (2020). Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends. Scientific Reports, 10(1), 17637

Abstract: The World Health Organization (WHO) called, in 2012, for a validated strategy towards Taenia solium taeniasis/cysticercosis control and elimination. Estimating pig force-of-infection (FoI, the average rate at which susceptible pigs become i... Read More about Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends.

Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation (2020)
Journal Article
Toor, J., Adams, E. R., Aliee, M., Amoah, B., Anderson, R. M., Ayabina, D., …Hollingsworth, T. D. (2020). Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation. Clinical Infectious Diseases, https://doi.org/10.1093/cid/ciaa933

Abstract Due to the COVID-19 pandemic, many key neglected tropical disease (NTD) activities have been postponed. This hindrance comes at a time when the NTDs are progressing towards their ambitious goals for 2030. Mathematical modelling on several NT... Read More about Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation.

Designing antifilarial drug trials using clinical trial simulators (2020)
Journal Article
Walker, M., Hamley, J., Milton, P., Monnot, F., Pedrique, B., & Basáñez, M. (2020). Designing antifilarial drug trials using clinical trial simulators. Nature Communications, 11(1), https://doi.org/10.1038/s41467-020-16442-y

Lymphatic filariasis and onchocerciasis are neglected tropical diseases (NTDs) targeted for elimination by mass (antifilarial) drug administration. These drugs are predominantly active against the microfilarial progeny of adult worms. New drugs or co... Read More about Designing antifilarial drug trials using clinical trial simulators.

Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa (2020)
Journal Article
Webster, J. P., Neves, M. I., Webster, B. L., Pennance, T., Rabone, M., Gouvras, A. N., …Rollinson, D. (2020). Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa. American Journal of Tropical Medicine and Hygiene, https://doi.org/10.4269/ajtmh.19-0827

Analyses of the population genetic structure of schistosomes under the “Schistosomiasis Consortium for Operational Research and Evaluation” (SCORE) contrasting treatment pressure scenarios in Tanzania, Niger, and Zanzibar were performed to provide su... Read More about Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa.

Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools (2020)
Journal Article
Walker, M., Webster, J. P., & Milne, G. (2020). Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools. Clinical Infectious Diseases, https://doi.org/10.1093/cid/ciaa428

Background. Horizontal transmission of Toxoplasma gondii occurs primarily via ingestion of environmental oocysts or con- sumption of undercooked/raw meat containing cyst-stage bradyzoites. The relative importance of these 2 transmission routes remain... Read More about Toward Improving Interventions Against Toxoplasmosis by Identifying Routes of Transmission Using Sporozoite- specific Serological Tools.

Structural Uncertainty in Onchocerciasis Transmission Models Influences the Estimation of Elimination Thresholds and Selection of Age Groups for Seromonitoring (2020)
Journal Article
Hamley, J. I. D., Walker, M., Coffeng, C. E., Milton, P., De Vlas, S. J., Stolk, W. A., & Basáñez, M. (2020). Structural Uncertainty in Onchocerciasis Transmission Models Influences the Estimation of Elimination Thresholds and Selection of Age Groups for Seromonitoring. Journal of Infectious Diseases, https://doi.org/10.1093/infdis/jiz674