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All Outputs (7)

Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1) (2019)
Journal Article
Draper, A. C. E., Wilson, Z., Maile, C. A., Faccenda, D., Campanella, M., & Piercy, R. J. (2019). Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1). FASEB Journal, https://doi.org/10.1096/fj.201901455R

A glutamic acid to lysine (E40K) residue substitution in superoxide dismutase 1 (SOD1) is associated with canine degenerative myelopathy: the only naturally occurring large animal model of amyotrophic lateral sclerosis (ALS). The E40 residue is highl... Read More about Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1).

Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy (2019)
Journal Article
Draper, A. C. E., Cahalan, S. D., Goodwin, D., Perkins, J. D. M., & Piercy, R. J. (2019). Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy. Muscle & Nerve, https://doi.org/10.1002/mus.26699

Equine recurrent laryngeal neuropathy (RLN) is a naturally occurring model of length‐dependent axonopathy characterised by asymmetrical degeneration of recurrent laryngeal nerve axons (RLn). Distal RLn degeneration is marked, however it is unclear wh... Read More about Assessing pathological changes within the nucleus ambiguus of horses with Recurrent Laryngeal Neuropathy: an extreme, length-dependent axonopathy.

Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty (2019)
Journal Article
Chesworth, M., Brandenberger, O., Cheetham, J., Windley, Z., Schumacher, J., Cochran, K., Piercy, R. J., & Perkins, J. D. M. (2019). Ex vivo investigation of the effect of the transverse arytenoid ligament on abduction of the arytenoid cartilage when performing equine laryngoplasty. New Zealand Veterinary Journal, 67(5), 264-269. https://doi.org/10.1080/00480169.2019.1635538

Energy turnover in mammalian skeletal muscle in contractions mimicking locomotion: effects of stimulus pattern on work, impulse and energetic cost and efficiency (2019)
Journal Article
Curtin, N. A., Woledge, R. C., West, T. G., Goodwin, D., Piercy, R. J., & Wilson, A. M. (2019). Energy turnover in mammalian skeletal muscle in contractions mimicking locomotion: effects of stimulus pattern on work, impulse and energetic cost and efficiency. Journal of Experimental Biology, 222, https://doi.org/10.1242/jeb.203877

Active muscle performs various mechanical functions during locomotion: work output during shortening, work absorption when resisting (but not preventing) lengthening, and impulse (force–time integral) whenever there is active force. The energetic cos... Read More about Energy turnover in mammalian skeletal muscle in contractions mimicking locomotion: effects of stimulus pattern on work, impulse and energetic cost and efficiency.

Identification and validation of genetic variants predictive of gait in standardbred horses (2019)
Journal Article
McCoy, A. M., Beeson, S. K., Rubin, C.-J., Andersson, L., Caputo, P., Lykkjen, S., Moore, A., Piercy, R. J., Mickelson, J. R., & McCue, M. E. (2019). Identification and validation of genetic variants predictive of gait in standardbred horses. PLoS Genetics, 15, e1008146. https://doi.org/10.1371/journal.pgen.1008146

Several horse breeds have been specifically selected for the ability to exhibit alternative patterns of locomotion, or gaits. A premature stop codon in the gene DMRT3 is permissive for “gaitedness” across breeds. However, this mutation is nearly fixe... Read More about Identification and validation of genetic variants predictive of gait in standardbred horses.

Functional Electrical Stimulation following nerve injury in a Large Animal Model (2019)
Journal Article
Cercone, M., Jarvis, J., Ducharme, N., Perkins, J. D. M., Piercy, R. J., Willand, M., Mitchell, L., Sledziona, M., Soderholm, L. V., & Cheetham, J. (2019). Functional Electrical Stimulation following nerve injury in a Large Animal Model. Muscle & Nerve, 59(6), 717-725. https://doi.org/10.1002/mus.26460

Introduction: Controversy exists over the effects of functional electrical stimulation (FES) on reinnervation. We hypothesized that intramuscular FES would not delay reinnervation after recurrent laryngeal nerve (RLn) axonotmesis. Methods: RLn cryo‐i... Read More about Functional Electrical Stimulation following nerve injury in a Large Animal Model.