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Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.

Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width (2014)
Journal Article
Perrett, R. M., Voliotis, M., Armstrong, S. P., Fowkes, R. C., Pope, G. R., Tsaneva-Atanasova, K., & McArdle, C. A. (2014). Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width. Journal of Biological Chemistry, 289(11), 7873-7883. https://doi.org/10.1074/jbc.M113.532473

Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction. It acts via G-protein-coupled receptors to stimulate effectors, i... Read More about Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width.

Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in L beta T2 gonadotrophs reveals disrupted cAMP-mediated gene transcription
Journal Article
Fowkes, R. C., Sidhu, K. K., Sosabowski, J., King, P., & Burrin, J. M. Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in L beta T2 gonadotrophs reveals disrupted cAMP-mediated gene transcription. Journal of Molecular Endocrinology, 31(2), 263-278. https://doi.org/10.1677/jme.0.0310263

11 beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology
Journal Article
Sharp, V., Thurston, L. M., Fowkes, R. C., & Michael, A. E. 11 beta-hydroxysteroid dehydrogenase enzymes in the testis and male reproductive tract of the boar (Sus scrofa domestica) indicate local roles for glucocorticoids in male reproductive physiology. Reproduction, 134(3), 473-482. https://doi.org/10.1530/REP-07-0126

Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alpha T3-1 and L beta T2 gonadotroph cells
Journal Article
Thompson, I. R., Chand, A. N., Jonas, K. C., Burrin, J. M., Steinhelper, M. E., Wheeler-Jones, C. P. D., …Fowkes, R. C. Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alpha T3-1 and L beta T2 gonadotroph cells. Journal of Endocrinology, 203(2), 215-229. https://doi.org/10.1677/joe-09-0189