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Lasting organ-level bone mechanoadaptation is unrelated to local strain (2020)
Journal Article
Javaheri, B., Razi, H., Gohin, S., Wylie, S., Chang, Y. M., Salmon, P., Lee, P. D., & Pitsillides, A. A. (2020). Lasting organ-level bone mechanoadaptation is unrelated to local strain. Science Advances, 6(10), https://doi.org/10.1126/sciadv.aax8301

Bones adapt to mechanical forces according to strict principles predicting straight shape. Most bones are, however, paradoxically curved. To solve this paradox, we used computed tomography–based, four-dimensional imaging methods and computational ana... Read More about Lasting organ-level bone mechanoadaptation is unrelated to local strain.

Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage (2020)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Magnusdottir, R., Hopkinson, M., Chang, Y. M., Poulet, B., Fowkes, R. C., Wood, J. N., & Chenu, C. (2020). Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage. Osteoarthritis and Cartilage, 28(3), 383-395. https://doi.org/10.1016/j.joca.2019.12.004

In osteoarthritis (OA), the pain-structure relationship remains complex and poorly understood. Here, we used the mechanical joint loading (MJL) model of OA to investigate both knee pathology and nociceptive behaviour.

Association between hyponatremia and neurological dysfunction in hospitalized foals (2019)
Journal Article
Dunkel, B., Dodson, F., Chang, Y. M., & Slovis, N. M. (2019). Association between hyponatremia and neurological dysfunction in hospitalized foals. Journal of Veterinary Emergency and Critical Care, 30(1), 66-73. https://doi.org/10.1111/vec.12906

Hyponatremia and rapid correction of hyponatremia can lead to neurological abnormalities. The objective of the study was to determine whether plasma sodium concentrations (Na+) and speed of correction of hyponatremia are significantly associated with... Read More about Association between hyponatremia and neurological dysfunction in hospitalized foals.

Divergent evolution of terrestrial locomotor abilities in extant Crocodylia (2019)
Journal Article
Hutchinson, J. R., Felkler, D., Houston, K., Chang, Y. M., Brueggen, J., Kledzik, D., & Vliet, K. A. (2019). Divergent evolution of terrestrial locomotor abilities in extant Crocodylia. https://doi.org/10.1038/s41598-019-55768-6

Extant Crocodylia are exceptional because they employ almost the full range of quadrupedal footfall patterns (“gaits”) used by mammals; including asymmetrical gaits such as galloping and bounding. Perhaps this capacity evolved in stem Crocodylomorpha... Read More about Divergent evolution of terrestrial locomotor abilities in extant Crocodylia.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows (2019)
Journal Article
Tombacz, K., Peters, L. M., Chang, Y. M., Steele, M., Werling, D., & Gibson, A. J. (2019). Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows. Journal of Dairy Science, 102(10), 9389-9395. https://doi.org/10.3168/jds.2019-16563

In periparturient dairy cows, immune suppression, resulting in decreased neutrophil numbers and function, leads to increased susceptibility to postpartum conditions such as mastitis, retained placenta, and metritis. Administration of polyethylene gly... Read More about Pegbovigrastim treatment in vivo does not affect granulocyte ability to migrate to endometrial cells and kill bacteria in vitro in healthy cows.

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial (2019)
Journal Article
Sanchis-Mora, S., Chang, Y. M., Abeyesinghe, S. M., Fisher, A., Upton, N., Volk, H. A., & Pelligand, L. (2019). Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. https://doi.org/10.1016/j.tvjl.2019.06.006

Pregabalin is the first-line treatment for neuropathic pain (NeP) in humans. Dogs with Chiari-like malformation and syringomyelia (CM/SM) associated with NeP could benefit from pregabalin. The aim of this study was to evaluate the efficacy of pregaba... Read More about Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial.

Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome (2019)
Journal Article
Pittaway, R., Dobromylskyj, M. J., Erles, K., Pittaway, C. E., Suárez-Bonnet, A., Chang, Y. M., & Priestnall, S. L. (2019). Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. Veterinary Pathology, 56(6), 868-877. https://doi.org/10.1177/0300985819854435

Nonocular melanocytic neoplasia is considered uncommon in cats yet is routinely encountered in diagnostic pathology and recognized to exhibit a wide variation in biological behavior. Accurate prediction of clinical outcomes is challenging with no wid... Read More about Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome.

Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases (2019)
Journal Article
Dunkel, B., Mason, C. J., & Chang, Y. M. (2019). Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.12851

A recent study described increased l‐lactate concentrations in ponies with gastrointestinal disease compared to horses, but blood glucose (BG) concentrations were not considered. The study tested the hypothesis that BG and l‐lactate concentrations ar... Read More about Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases.

Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares (2019)
Journal Article
De Mestre, A. M., Rose, V. B., Chang, Y. M., Wathes, D. C., & Verheyen, K. L. P. (2019). Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares. Theriogenology, 124, 18-23. https://doi.org/10.1016/j.theriogenology.2018.10.008

Early pregnancy loss (EPL) between days 15–65 after breeding has been shown to occur in 7.9% of equine pregnancies with substantial economical, welfare and safety implications. Whilst maternal age has been recognised as an important risk factor in re... Read More about Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares.

Survival after diagnosis of hypertension in cats attending primary care practice in the UK (2018)
Journal Article
Chang, Y. M., Brodbelt, D. C., Elliott, J., & Conroy, M. C. (2018). Survival after diagnosis of hypertension in cats attending primary care practice in the UK. Journal of Veterinary Internal Medicine, 32(6), 1846-1855. https://doi.org/10.1111/jvim.15307

Background: Hypertension is common in older cats. There is limited evidence for predictors of
survival after diagnosis.
Hypothesis/Objectives: Investigate blood pressure assessment (BPA) and hypertension diagnosis
in cats attending UK primary care... Read More about Survival after diagnosis of hypertension in cats attending primary care practice in the UK.

Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya (2018)
Journal Article
Carron, M., Chang, Y. M., Momanyi, K., Akoko, J., Kiiru, J., Bettridge, J. M., Chaloner, G., Rushton, J., O'Brien, S. J., Williams, N., Fèvre, E. M., & Haesler, B. (2018). Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya. PLoS Neglected Tropical Diseases, 12(8), e0006658. https://doi.org/10.1371/journal.pntd.0006658

Campylobacteriosis is a leading foodborne zoonosis worldwide, and is frequently associated with handling and consumption of poultry meat. Various studies indicate that Campylobacter causes a substantial human disease burden in low to middle-income co... Read More about Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya.

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice (2018)
Journal Article
Javaheri, B., Razi, H., Piles, M., De Souza, R., Chang, Y. M., Maric-Mur, I., Hopkinson, M., Lee, P. D., & Pitsillides, A. A. (2018). Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage, 26(6), 807-817. https://doi.org/10.1016/j.joca.2018.03.008

Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. We exploit the lack of overt OA in female STR/Ort and i... Read More about Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.

Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease (2018)
Journal Article
Van Den Broek, D. H. N., Geddes, R. F., Williams, T. L., Chang, Y. M., Elliott, J., & Jepson, R. E. (2018). Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 32(2), 727-735. https://doi.org/10.1111/jvim.15051

Background:
Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats.

Objectives:
To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of... Read More about Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.

Occurrence of preterm calving in Great Britain and associations with milk production and reproductive performance in dairy cattle (2018)
Journal Article
Damaso, A. F., Velasova, M., Van Winden, S. C. L., Chang, Y. M., & Guitian, J. (2018). Occurrence of preterm calving in Great Britain and associations with milk production and reproductive performance in dairy cattle. Veterinary Record Open, 5, e000221. https://doi.org/10.1136/vetreco-2017-000221

This study describes the occurrence of preterm calving in Great Britain and evaluates its associations with subsequent milk production and reproductive performances and survival on farm of dairy cows. A total of 53 British dairy farms and 5759 animal... Read More about Occurrence of preterm calving in Great Britain and associations with milk production and reproductive performance in dairy cattle.

Modulation of foraging strategy in response to distinct prey items and their scents in the aquatic frog Xenopus longipes (Anura: Pipidae) (2018)
Journal Article
Michaels, C. J., Das, S., Chang, Y. M., & Tapley, B. (2018). Modulation of foraging strategy in response to distinct prey items and their scents in the aquatic frog Xenopus longipes (Anura: Pipidae)

Aquatic predators must forage for prey in a complex three-dimensional environment where the availability of different prey types with different spatial niches may vary. Aquatic predators have evolved a number of ways in which they may respond to this... Read More about Modulation of foraging strategy in response to distinct prey items and their scents in the aquatic frog Xenopus longipes (Anura: Pipidae).

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs (2017)
Journal Article
Lee, K. C. L., Baker, L., Mallett, S., Riddell, A., Chowdary, P., Alibhai, H. I. K., Chang, Y. M., Priestnall, S. L., Stanzani, G., Davies, N., Mookerjee, R., Jalan, R., & Agarwal, B. (2017). Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs. https://doi.org/10.1038/s41598-017-09508-3

Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists. This study defines evolution of coagulopathy in 10 pigs wi... Read More about Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs.