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All Outputs (13)

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., Wastling, J., Ortega-Mora, L. M., & Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum. Pathogens, 9(9), 749

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of Neospora caninum. Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known abou... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by (2020)
Journal Article
Regidor-Cerrillo, J., Xia, D., Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Randle, N., Wastling, J., Ortega-Mora, L. M., & Horcajo, P. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by. Pathogens, 9(9),

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of . Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known about the relation... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis (2019)
Presentation / Conference Contribution
Ballesteros, R., Xia, D., O'Shaughnessy, P., & Mukherjee, A. The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis

Spermatogenesis in mammals depends on the function of Sertoli cells (SC). The total number of SC present in the testes is determined in the pre-pubertal stages of development. Activin, a TGFβ family ligand, regulates SC proliferation in the early pos... Read More about The Role Of Fstl3 In Spermatogenesis: A Transcriptome Analysis.

Genomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism (2018)
Journal Article
Dong, X., Chaisiri, K., Xia, D., Armstrong, S. D., Fang, Y., Donnelly, M. J., Kadowaki, T., McGarry, J. W., Darby, A. C., & Makepeace, B. L. (2018). Genomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism. GigaScience, 7(12), https://doi.org/10.1093/gigascience/giy127

Trombidid mites have a unique lifecycle in which only the larval stage is ectoparasitic. In the superfamily Trombiculoidea (“chiggers”), the larvae feed preferentially on vertebrates, including humans. Species in the genus Leptotrombidium are vectors... Read More about Genomes of trombidid mites reveal novel predicted allergens and laterally-transferred genes associated with secondary metabolism.

Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle (2018)
Journal Article
Horcajo, P., Xia, D., Randle, N., Collantes-Fernández, E., Wastling, J., Ortega-Mora, L. M., & Regidor-Cerrillo, J. (2018). Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle. Journal of Proteomics, 180, 108-119. https://doi.org/10.1016/j.jprot.2017.11.007

Neospora caninum is one of the main causes of transmissible abortion in cattle. Intraspecific variations in virulence have been widely shown among N. caninum isolates. However, the molecular basis governing such variability have not been elucidated t... Read More about Integrative transcriptome and proteome analyses define marked differences between Neospora caninum isolates throughout the tachyzoite lytic cycle.

The genomic basis of parasitism in the Strongyloides clade of nematodes (2016)
Journal Article
Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., Tracey, A., Cotton, J. A., Stanley, E. J., Beasley, H., Bennett, H. M., Brooks, K., Harsha, B., Kajitani, R., Kulkarni, A., Harbecke, D., Nagayasu, E., Nichol, S., Ogura, Y., Quail, M. A., …Berriman, M. (2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48(3), 299-307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes.

A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum (2015)
Journal Article
Krishna, R., Xia, D., Sanderson, S., Shanmugasundram, A., Vermont, S., Bernal, A., Daniel-Naguib, G., Ghali, F., Brunk, B. P., Roos, D. S., Wastling, J. M., & Jones, A. R. (2015). A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum. Proteomics, 15(15), 261828. https://doi.org/10.1002/pmic.201400553

Proteomics data can supplement genome annotation efforts, for example being used to confirm gene models or correct gene annotation errors. Here, we present a large‐scale proteogenomics study of two important apicomplexan pathogens: Toxoplasma gondii... Read More about A large-scale proteogenomics study of apicomplexan pathogens-Toxoplasma gondii and Neospora caninum.

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii
Journal Article
Shukla, A., Olszewski, K. L., Llinas, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Xia, D., Wastling, J., Beitig, D., Roos, D. S., & Shanmugam, D. Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii. International Journal for Parasitology, 48(12), 955-968. https://doi.org/10.1016/j.ijpara.2018.05.013

Toxoplasma gondii can grow and replicate using either glucose or glutamine as the major carbon source. Here, we have studied the essentiality of glycolysis in the tachyzoite and bradyzoite stages of T. gondii, using transgenic parasites that lack a f... Read More about Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii.

Characterization of the interactome of the porcine reproductive and respiratory syndrome virus (PRRSV) NSP2 protein reveals the hyper variable region as a binding platform for association with 14-3-3 proteins
Journal Article
Xiao, Y., Wu, W., Gao, J., Smith, N., Burkard, C., Xia, D., Zhang, M., Wang, C., Archibald, A. L., Digard, P., Zhou, E. M., & Hiscox, J. A. (in press). Characterization of the interactome of the porcine reproductive and respiratory syndrome virus (PRRSV) NSP2 protein reveals the hyper variable region as a binding platform for association with 14-3-3 proteins. Journal of Proteome Research, https://doi.org/10.1021/acs.jproteome.5b00396

Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites
Journal Article
Armstrong, S. D., Babayan, S. A., Lhermitte-Vallarino, N., Gray, N., Xia, D., Martin, C., Kumar, S., Taylor, D. W., Blaxter, M. L., Wastling, J. M., & Makepeace, B. L. (in press). Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites. https://doi.org/10.1074/mcp.M114.038539

Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of ∼6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No... Read More about Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites.