All Outputs (10)

Dissecting the Phenotype and Genotype of PLA2G6‐Related Parkinsonism (2021)
Journal Article
Magrinelli, F., Mehta, S., Di Lazzaro, G., Latorre, A., Edwards, M. J., Balint, B., Basu, P., Kobylecki, C., Groppa, S., Hegde, A., Mulroy, E., Estevez‐Fraga, C., Arora, A., Kumar, H., Schneider, S. A., Lewis, P. A., Jaunmuktane, Z., Revesz, T., Gandhi, S., Wood, N. W., …Bhatia, K. P. (in press). Dissecting the Phenotype and Genotype of PLA2G6‐Related Parkinsonism. Movement Disorders, https://doi.org/10.1002/mds.28807

Background

Complex parkinsonism is the commonest phenotype in late-onset PLA2G6-associated neurodegeneration.

Objectives

The aim of this study was to deeply characterize phenogenotypically PLA2G6-related parkinsonism in the largest cohort ev... Read More about Dissecting the Phenotype and Genotype of PLA2G6‐Related Parkinsonism.

SORL1 mutation in a Greek family with Parkinson's disease and dementia (2021)
Journal Article
Xiromerisiou, G., Bourinaris, T., Houlden, H., Lewis, P. A., Senkevich, K., Hammer, M., Federoff, M., Khan, A., Spanaki, C., Hadjigeorgiou, G. M., Bonstanjopoulou, S., Fidani, L., Ermolaev, A., Gan‐Or, Z., Singleton, A., Vandrovcova, J., & Hardy, J. (2021). SORL1 mutation in a Greek family with Parkinson's disease and dementia. Annals of Clinical and Translational Neurology, https://doi.org/10.1002/acn3.51433

In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung (2021)
Journal Article
Verma, A., Ebanks, K., Fok, C.-Y., Lewis, P. A., Bettencourt, C., & Bandopadhyay, R. (2021). In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung. Brain Research, 1765, 147503. https://doi.org/10.1016/j.brainres.2021.147503

Modelling the functional genomics of Parkinson’s disease in Caenorhabditis elegans: LRRK2 and beyond (2021)
Journal Article
Chandler, R., Cogo, S., Lewis, P., & Kevei, E. (2021). Modelling the functional genomics of Parkinson’s disease in Caenorhabditis elegans: LRRK2 and beyond. Bioscience Reports, 41(9), https://doi.org/10.1042/bsr20203672

Vesicle trafficking and pathways to neurodegeneration (2021)
Journal Article
Blackstone, C., Elwood, F., Plun-Favreau, H., & Lewis, P. A. (2021). Vesicle trafficking and pathways to neurodegeneration. Molecular Neurodegeneration, 16(1), https://doi.org/10.1186/s13024-021-00480-1

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells (2021)
Journal Article
Nazish, I., Arber, C., Piers, T. M., Warner, T. T., Hardy, J. A., Lewis, P. A., Pocock, J. M., & Bandopadhyay, R. (2021). Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells. Neurochemistry International, 147, 105070. https://doi.org/10.1016/j.neuint.2021.105070

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein (2021)
Journal Article
Kara, E., Crimi, A., Wiedmer, A., Emmenegger, M., Manzoni, C., Bandres-Ciga, S., D’Sa, K., Reynolds, R. H., Botía, J. A., Losa, M., Lysenko, V., Carta, M., Heinzer, D., Avar, M., Chincisan, A., Blauwendraat, C., García-Ruiz, S., Pease, D., Mottier, L., Carrella, A., …Aguzzi, A. (2021). An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Reports, 35(10), 109189. https://doi.org/10.1016/j.celrep.2021.109189

Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias (2021)
Journal Article
Vavouraki, N., Tomkins, J. E., Kara, E., Houlden, H., Hardy, J., Tindall, M. J., Lewis, P. A., & Manzoni, C. (2021). Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 102484. https://doi.org/10.1016/j.isci.2021.102484

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo (2021)
Journal Article
Mamais, A., Cookson, M. R., Lewis, P. A., Manzoni, C., Li, Y., Mazza, M. C., & Kluss, J. H. (2021). Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo. Molecular Neurodegeneration, 16(1), https://doi.org/10.1186/s13024-021-00441-8

Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets (2021)
Journal Article
Kia, D. A., Zhang, D., Guelfi, S., Manzoni, C., Hubbard, L., Reynolds, R. H., Botía, J., Ryten, M., Ferrari, R., Lewis, P. A., Williams, N., Trabzuni, D., Hardy, J., Wood, N. W., Noyce, A. J., Kaiyrzhanov, R., Middlehurst, B., Kia, D. A., Tan, M., Houlden, H., …United Kingdom Brain Expression Consortium (UKBEC) and the International Parkinson’s Disease Genomics Consortium (IPDGC). (2021). Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets. JAMA Neurology, 78(4), 464. https://doi.org/10.1001/jamaneurol.2020.5257

IMPORTANCE Substantial genome-wide association study (GWAS) work in Parkinson disease (PD) has led to the discovery of an increasing number of loci shown reliably to be associated with increased risk of disease. Improved understanding of the underlyi... Read More about Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets.