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Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK (2018)
Journal Article
Stevens, K. B., Jepson, R. E., Holm, L. P., Walker, D. J., & Cardwell, J. M. (2018). Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK. Veterinary Record, 183(16), 502. https://doi.org/10.1136/vr.104892

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an incre... Read More about Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK.

Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy (2018)
Journal Article
Skulberg, R., Cortellini, S., Chan, D. L., Giacomo, S., & Jepson, R. E. (2018). Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy. Frontiers in Veterinary Science, 5(161), https://doi.org/10.3389/fvets.2018.00161

Cutaneous and renal glomerular vasculopathy (CRGV) is a rare disease affecting dogs, with a recent apparent increase in prevalence since 2012 in the UK. This disease is characterized by a vasculopathy affecting small vessels of the kidney and skin, l... Read More about Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy.

Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease (2018)
Journal Article
Van Den Broek, D. H. N., Geddes, R. F., Williams, T. L., Chang, Y. M., Elliott, J., & Jepson, R. E. (2018). Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 32(2), 727-735. https://doi.org/10.1111/jvim.15051

Background:
Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats.

Objectives:
To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of... Read More about Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.

Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats (2018)
Journal Article
Geddes, R. F., Jepson, R. E., Forcada, Y., Elliott, J., & Syme, H. M. (2018). Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats. https://doi.org/10.1016/j.tvjl.2018.02.010

Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nuc... Read More about Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats.

Systemic hypertension in cats with acute kidney injury (2017)
Journal Article
Cole, L., Jepson, R. E., & Humm, K. R. (2017). Systemic hypertension in cats with acute kidney injury. Journal of Small Animal Practice, 58(10), 577-581. https://doi.org/10.1111/jsap.12726

Retrospective study of cats presenting to the Queen Mother Hospital for Animals, Royal Veterinary College with acute kidney injury between 2007 and 2015. Systolic blood pressure was measured using Doppler sphygmomanometry and systemic hypertension wa... Read More about Systemic hypertension in cats with acute kidney injury.

Plasma N-Terminal Probrain Natriuretic Peptide, Vascular Endothelial Growth Factor, and Cardiac Troponin I as Novel Biomarkers of Hypertensive Disease and Target Organ Damage in Cats (2017)
Journal Article
Bijsmans, E. S., Jepson, R. E., Wheeler, C., Syme, H. M., & Elliott, J. (2017). Plasma N-Terminal Probrain Natriuretic Peptide, Vascular Endothelial Growth Factor, and Cardiac Troponin I as Novel Biomarkers of Hypertensive Disease and Target Organ Damage in Cats. Journal of Veterinary Internal Medicine, 31(3), 650-660. https://doi.org/10.1111/jvim.14655

Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats (2016)
Journal Article
Bijsmans, E. S., Doig, M., Jepson, R. E., Syme, H. M., Elliott, J., & Pelligand, L. (2016). Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats. Journal of Veterinary Internal Medicine, 30(5), 1630-1636. https://doi.org/10.1111/jvim.14562

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury (2015)
Journal Article
Lawson, J. S., Elliott, J., Wheeler-Jones, C. P. D., Syme, H. M., & Jepson, R. E. (2015). Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury. https://doi.org/10.1016/j.tvjl.2014.10.009

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised... Read More about Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury.

Plasma asymmetric dimethylarginine, symmetric dimethylarginine, L-arginine, and nitrite/nitrate concentrations in cats with chronic kidney disease and hypertension
Journal Article
Jepson, R. E., Syme, H. M., Vallance, C., & Elliott, J. Plasma asymmetric dimethylarginine, symmetric dimethylarginine, L-arginine, and nitrite/nitrate concentrations in cats with chronic kidney disease and hypertension. Journal of Veterinary Internal Medicine, 22(2), 317-324. https://doi.org/10.1111/j.1939-1676.2008.0075.x

Background: Chronic kidney disease (CKD) and hypertension have been associated with decreased bioavailability of nitric oxide (NO) and endothelial dysfunction. Increased concentrations of the endothelial nitric oxide synthase (eNOS) inhibitor asymmet... Read More about Plasma asymmetric dimethylarginine, symmetric dimethylarginine, L-arginine, and nitrite/nitrate concentrations in cats with chronic kidney disease and hypertension.