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Phase response curves and the role of coordinates (2024)
Journal Article
Wilshin, S., Kvalheim, M., & Revzen, S. (2024). Phase response curves and the role of coordinates. Biological Cybernetics, https://doi.org/10.1007/s00422-024-00997-w

The "infinitesimal phase response curve" (PRC) is a common tool used to analyze phase resetting in the natural sciences in general and neuroscience in particular. We make the observation that the PRC with respect to a coordinate v actually depends on... Read More about Phase response curves and the role of coordinates.

Otitis media/interna and encephalitozoonosis are the most common causes of head tilt in pet rabbits in the UK: 73 cases (2009-2020) (2024)
Journal Article
Liatis, T., Makri, N., Czopowicz, M., Richardson, J., Nuttall, T., & Suñol, A. (2024). Otitis media/interna and encephalitozoonosis are the most common causes of head tilt in pet rabbits in the UK: 73 cases (2009-2020). Veterinary Record, https://doi.org/10.1002/vetr.4267

BackgroundThere are limited studies that identify diseases associated with head tilt in pet rabbits.MethodsThis was an observational, retrospective, single-centre study of rabbits with head tilt presented between 2009 and 2020. Descriptive statistics... Read More about Otitis media/interna and encephalitozoonosis are the most common causes of head tilt in pet rabbits in the UK: 73 cases (2009-2020).

A review of the equine suspensory ligament: Injury prone yet understudied (2024)
Journal Article
Guest, D. J., Birch, H. L., & Thorpe, C. T. (2024). A review of the equine suspensory ligament: Injury prone yet understudied. Equine Veterinary Journal, 1-16. https://doi.org/10.1111/evj.14447

The suspensory ligament (SL) is a key component of the elaborate and highly adapted suspensory apparatus in the horse. In addition to contributing to stabilisation of the metacarpophalangeal joint, the SL has a spring like function to reduce the ener... Read More about A review of the equine suspensory ligament: Injury prone yet understudied.

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia (2024)
Journal Article
Arber, C., Casey, J., Crawford, S., Rambarack, N., Yaman, U., Wiethoff, S., Augustin, E., Piers, T., Price, M., Rostagno, A., Ghiso, J., Lewis, P., Revesz, T., Hardy, J., Pocock, J., Houlden, H., Schott, J., Salih, D., Lashley, T., & Wray, S. (2024). Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia. Acta Neuropathologica, 148(1), https://doi.org/10.1007/s00401-024-02820-z

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-terminal cleavage fragment of the ITM2B/BRI2 protein... Read More about Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia.

A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones (2024)
Journal Article
Sánchez-Lanzas, R., Barclay, J., Chardas, A., Kalampalika, F., Jiménez-Pompa, A., Gallipoli, P., & Ganuza, M. (2024). A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones. Leukemia, https://doi.org/10.1038/s41375-024-02464-8

Clonal hematopoiesis (CH) is nearly universal in the elderly. The molecular and cellular mechanisms driving CH and the clinical consequences of carrying clonally derived mutant mature blood cells are poorly understood. We recently identified a C223Y... Read More about A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones.

White paper formatted for Endocrine Oncology NET models meeting 2024 White Paper: the current state of neuroendocrine tumour research models and our future aspirations (2024)
Journal Article
Hien Ear, P., Marinoni, I., Dayton, T., Guenter, R., Quelle, D. E., Battistella, A., Buishand, F. O., Chittaranjan, S., Du, Y.-C. N., Marques, I., Pellegata, N., Sadowski, S. M., Tirosh, A., April-Monn, S., Aurilia, C., Jaskula-Sztul, R., Jesús, M., Moreno, B., Donati, S., English, K. A., …Schrader, J. (2024). White paper formatted for Endocrine Oncology NET models meeting 2024 White Paper: the current state of neuroendocrine tumour research models and our future aspirations. Endocrine Oncology, https://doi.org/10.1530/EO-24-0055

A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria (2024)
Journal Article
Corbetta, D., Grau-Roma, L., Rees, C., Swift, B., O'Cathail, C., Barron, E., Verin, R., Morey-Matamalas, A., Sorley, M., & Bennett, M. (2024). A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria. European Journal of Wildlife Research, 70(6), https://doi.org/10.1007/s10344-024-01866-4

European badgers (Meles meles) play an important role in the epidemiology of bovine tuberculosis (caused by Mycobacterium bovis) in England, but little is known about the prevalence of atypical mycobacteriosis. Badgers are also known to be infected b... Read More about A histopathological study in road-killed European badgers (Meles meles) from the English midlands with isolation of novel non-tuberculous atypical mycobacteria.

Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile (2024)
Journal Article
Gutierrez, B., Tsui, J., Pullano, G., Mazzoli, M., Gangavarapu, K., Inward, R., Bajaj, S., Pena, R., Busch-Moreno, S., Suchard, M., Pybus, O., Dunner, A., Puentes, R., Ayala, S., Fernandez, J., Araos, R., Ferres, L., Colizza, V., & Kraemer, M. (2024). Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile. PNAS Nexus, 3(11), https://doi.org/10.1093/pnasnexus/pgae483

Human mobility is strongly associated with the spread of SARS-CoV-2 via air travel on an international scale and with population mixing and the number of people moving between locations on a local scale. However, these conclusions are drawn mostly fr... Read More about Routes of importation and spatial dynamics of SARS-CoV-2 variants during localized interventions in Chile.

A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023) (2024)
Journal Article
Loomes, K., de Grauw, J., Gozalo-Marcilla, M., Redondo, J., & Bettschart-Wolfensberger, R. (2024). A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023). Equine Veterinary Journal, https://doi.org/10.1111/evj.14416

Background Equine post-operative morbidity represents a significant concern for both veterinary surgeons and horse owners. Objectives To estimate the prevalence of post-operative complications in horses after elective/non-abdominal surgery or colic s... Read More about A systematic review of the prevalence of post-operative complications after general anaesthesia in adult horses (2000-2023).

Investigating the resistome of haemolytic bacteria in Arctic soils (2024)
Journal Article
Mogrovejo-Arias, D., Hay, M., Edwards, A., Mitchell, A., Steinmann, J., Brill, F., & Neumann, B. (2024). Investigating the resistome of haemolytic bacteria in Arctic soils. Environmental Microbiology Reports, 16(5), https://doi.org/10.1111/1758-2229.70028

Microorganisms inhabiting hostile Arctic environments express a variety of functional phenotypes, some of clinical interest, such as haemolytic ability and antimicrobial resistance. We studied haemolytic bacterial isolates from Arctic habitats, asses... Read More about Investigating the resistome of haemolytic bacteria in Arctic soils.

Comparison of outcomes in dogs undergoing hiatal hernia repair with and without use of a gastropexy: 41 cases (2012-2022) (2024)
Journal Article
Watkins, M., Shales, C., Thomas, G., Rossanese, M., Sparks, T., & White, R. (2024). Comparison of outcomes in dogs undergoing hiatal hernia repair with and without use of a gastropexy: 41 cases (2012-2022). Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13797

Objectives: To determine the difference in complication rate, gastrointestinal grade and requirement for ongoing medical and/or surgical management following hiatal hernia repair in dogs with and without gastropexy. Materials and methods: Clinical re... Read More about Comparison of outcomes in dogs undergoing hiatal hernia repair with and without use of a gastropexy: 41 cases (2012-2022).

Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis) (2024)
Journal Article
Martí-García, B., Priestnall, S., Torres, Y., & Suárez-Bonnet, A. (2024). Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Laboratory Animals, https://doi.org/10.1177/00236772241273060

Three seven-year-old African clawed frogs (Xenopus laevis) from an animal research facility showed weight loss, coelomic distention and an abnormal swimming gait were euthanised on welfare grounds. A complete necropsy of each animal showed a focal, f... Read More about Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis).

Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors (2024)
Journal Article
Watson, A., Syme, H., & Brown, M. (2024). Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors. Hypertension, 81(12), 2489-2500. https://doi.org/10.1161/HYPERTENSIONAHA.124.23501

BACKGROUND:Primary aldosteronism (PA) is a common cause of human hypertension. Somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 are found in at least 80% of aldosterone-producing adenomas, which cause unilateral PA in humans. Somatic mutations... Read More about Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors.

Comparison of CHOP-19 and CHOP-25 for treatment of peripheral nodal B-cell lymphoma in dogs: A European multicenter retrospective cohort study (2024)
Journal Article
Hawkes, C., Morris, J., Bavcar, S., Wilkie, C., Ray, S., Auquier, C., Benjamin, S., Masso, J., Bottin, S., Davies, O., Desmas-Bazelle, I., Einhorn, A., Figueroa-Gonzalez, C., Holenova, K., Kritsotalaki, E., Peak, K., Smallwood, K., Treggiari, E., Valenti, P., de la Virgen, M., & Fournier, Q. (2024). Comparison of CHOP-19 and CHOP-25 for treatment of peripheral nodal B-cell lymphoma in dogs: A European multicenter retrospective cohort study. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17222

BackgroundPeripheral nodal B-cell lymphomas (PNBCL) represent the most common presentation of lymphomas in dogs. Multiagent CHOP (C = cyclophosphamide, H = hydroxydaunorubicin [Doxorubicin], O = Oncovin, P = prednisolone)-based chemotherapy protocols... Read More about Comparison of CHOP-19 and CHOP-25 for treatment of peripheral nodal B-cell lymphoma in dogs: A European multicenter retrospective cohort study.

Antimicrobial resistance in plant endophytes associated with poultry-manure application revealed by selective culture and whole genome sequencing (2024)
Journal Article
Tripathi, A., Jaiswal, A., Kumar, D., Chavda, P., Pandit, R., Joshi, M., Blake, D., Tomley, F., Joshi, C., & Dubey, S. (2024). Antimicrobial resistance in plant endophytes associated with poultry-manure application revealed by selective culture and whole genome sequencing. Journal of Hazardous Materials, 480, https://doi.org/10.1016/j.jhazmat.2024.136166

Poultry manure is widely used as organic fertilizer in agriculture during the cultivation of crops, but the persistent high-level use of antibiotics in poultry production has raised concerns about the selection for reservoirs of antimicrobial resista... Read More about Antimicrobial resistance in plant endophytes associated with poultry-manure application revealed by selective culture and whole genome sequencing.

Hoof slip duration at impact in galloping Thoroughbred ex-racehorses trialling eight shoe-surface combinations (2024)
Journal Article
Horan, K., Coburn, J., Kourdache, K., Day, P., Carnall, H., Brinkley, L., Harborne, D., Hammond, L., Millard, S., Weller, R., & Pfau, T. (2024). Hoof slip duration at impact in galloping Thoroughbred ex-racehorses trialling eight shoe-surface combinations. PLoS ONE, 19(10), https://doi.org/10.1371/journal.pone.0311899

Horseshoes used during racing are a major determinant of safety as they play a critical role in providing traction with the ground surface. Although excessive hoof slip is detrimental and can predispose to instabilities, falls and injuries, some slip... Read More about Hoof slip duration at impact in galloping Thoroughbred ex-racehorses trialling eight shoe-surface combinations.

Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors (2024)
Journal Article
Allan, F., Watson, A., & Syme, H. (2024). Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17212

Background: Functionality of human adrenal tumors is inferred by CYP11B1 (cortisol synthase) expression, CYP11B2 (aldosterone synthase) expression, or both. Hypothesis/Objectives: Nonfunctional canine adrenal tumors have low expression of steroidogen... Read More about Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors.

New theropod dinosaur remains from the Upper Cretaceous of the Kem Kem Group (Eastern Morocco) clarify spinosaurid morphology (2024)
Journal Article
Hutchinson, J., Lacerda, M. B. S., Isasmendi, E., Delcourt, R., & Fernandes, M. A. (2024). New theropod dinosaur remains from the Upper Cretaceous of the Kem Kem Group (Eastern Morocco) clarify spinosaurid morphology. Zoological Journal of the Linnean Society, https://doi.org/10.1093/zoolinnean/zlae109

The Kem Kem Group is a lowermost lithostratigraphic unit from the Upper Cretaceous that extends along the border between Algeria and Morocco, in the northern region of Africa. This geological unit has yielded several tetrapod fossils, including a wel... Read More about New theropod dinosaur remains from the Upper Cretaceous of the Kem Kem Group (Eastern Morocco) clarify spinosaurid morphology.

Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics (2024)
Journal Article
Kuroda, T., Minamijima, Y., Kinman, C., Takahashi, Y., Ebisuda, Y., Inoue, K., Ishikawa, H., Mita, H., Tamura, N., Nukada, T., Toutain, P., & Ohta, M. (2024). Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics. Frontiers in Veterinary Science, 11, https://doi.org/10.3389/fvets.2024.1454342

Introduction Quinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects. The purpose of this study... Read More about Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics.