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All Outputs (6)

Predicting cortical bone adaptation to axial loading in the mouse tibia (2015)
Journal Article
Pereira, A. F., Javaheri, B., Pitsillides, A. A., & Shefelbine, S. J. (2015). Predicting cortical bone adaptation to axial loading in the mouse tibia. https://doi.org/10.1098/rsif.2015.0590

The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces. The objective of this work was to predict, with spatia... Read More about Predicting cortical bone adaptation to axial loading in the mouse tibia.

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing (2015)
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y. M., Houston, D. A., Oldknow, K. J., …Pitsillides, A. A. (2015). Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. BONE, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalaci... Read More about Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis (2015)
Journal Article
Akbareian, S. E., Pitsillides, A. A., Macharia, R. G., & McGonnell, I. M. (2015). Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis. Journal of Anatomy, 226(6), 560-574. https://doi.org/10.1111/joa.12304

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery,... Read More about Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.

Local origins impart conserved bone type-related differences in human osteoblast behaviour (2015)
Journal Article
Shah, M., Gburcik, V., Reilly, P., Sankey, R. A., Emery, R. J., Clarkin, C. E., & Pitsillides, A. A. (2015). Local origins impart conserved bone type-related differences in human osteoblast behaviour. https://doi.org/10.22203/eCM.v029a12

Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; a... Read More about Local origins impart conserved bone type-related differences in human osteoblast behaviour.

Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds (2015)
Journal Article
Regnault, S., Pitsillides, A. A., & Hutchinson, J. R. (2015). Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds. https://doi.org/10.7717/peerj.711

The patella (kneecap) exhibits multiple evolutionary origins in birds, mammals, and lizards, and is thought to increase the mechanical advantage of the knee extensor muscles. Despite appreciable interest in the specialized anatomy and locomotion of p... Read More about Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds.