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Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors (2020)
Journal Article
Schofield, I., Woolhead, V., Johnson, A., Brodbelt, D. C., Church, D. B., & O'Neill, D. G. (2020). Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors. Journal of Small Animal Practice, 1-8. https://doi.org/10.1111/jsap.13285

Objectives: To estimate the frequency, clinical approaches and risk factors of hypoadrenocorticism in dogs under UK primary veterinary care. Materials and MethOds: Dogs diagnosed with hypoadrenocorticism were identified from the UK VetCompass™ progr... Read More about Hypoadrenocorticism in dogs under UK primary veterinary care: frequency, clinical approaches and risk factors.

Blood taurine concentrations in dogs with exocrine pancreatic insufficiency (2020)
Journal Article
Tayler, S., Seo, J., Connolly, D. J., & Kathrani, A. (2020). Blood taurine concentrations in dogs with exocrine pancreatic insufficiency. American Journal of Veterinary Research, 81(12), 958-963. https://doi.org/10.2460/ajvr.81.12.958

Objective: To determine whether blood taurine concentrations in dogs with exocrine pancreatic insufficiency (EPI) were lower than the reference interval (200 to 350 nmol/mL) or the cutoff used to indicate taurine deficiency (< 150 nmol/mL). Animal... Read More about Blood taurine concentrations in dogs with exocrine pancreatic insufficiency.

Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease (2020)
Journal Article
Jepson, R., Elliott, J., Geddes, R., Chang, Y., & Tang, P. (2020). Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 1-12. https://doi.org/10.1111/jvim.15996

Background Dietary phosphate restriction improves survival in cats with chronic kidney disease (CKD). However, feeding a phosphate‐restricted diet may disrupt calcium homeostasis leading to hypercalcemia in some cats. Objectives To identify... Read More about Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease.

Three-dimensional visualization as a tool for interpreting locomotion strategies in ophiuroids from the Devonian Hunsrück Slate (2020)
Journal Article
Clark, E. G., Hutchinson, J. R., & Briggs, D. E. G. (2020). Three-dimensional visualization as a tool for interpreting locomotion strategies in ophiuroids from the Devonian Hunsrück Slate. Royal Society Open Science, 7(12), 201380. https://doi.org/10.1098/rsos.201380

Living brittle stars (Echinodermata: Ophiuroidea) employ a very different locomotion strategy to that of any other metazoan: five or more arms coordinate powerful strides for rapid movement across the ocean floor. This mode of locomotion is reliant o... Read More about Three-dimensional visualization as a tool for interpreting locomotion strategies in ophiuroids from the Devonian Hunsrück Slate.

Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens (2020)
Journal Article
Frosini, S., Bond, R., McCarthy, A., Feudi, C., Schwarz, S., Lindsay, J., & Loeffler, A. (2020). Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens. Microorganisms, https://doi.org/10.3390/microorganisms8122031

Transmission of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus pseudintermedius (MRSP) between people and pets, and their co-carriage, are well-described. Potential exchange of antimicrobial resistance (AM... Read More about Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens.

Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Faccenda, D., Alvarex, M. S., …Campanella, M. (2020). Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response. Science Advances, https://doi.org/10.1101/445411

Cholesterol metabolism is pivotal to cellular homeostasis, hormones production, and membranes composition. Its dysregulation associates with malignant reprogramming and therapy resistance. Cholesterol is trafficked into the mitochondria for steroidog... Read More about Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Rigon, M., Faccenda, D., …Campanella, M. (in press). Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response. Science Advances, https://doi.org/10.1101/445411

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as Mitochondrial Retrograde Response (MRR) and is induced by mitochondrial dysfunctions. MRR results in the nuclear stabilization of pro-s... Read More about Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response.

Evaluation of Pneumococcal Serotyping of Nasopharyngeal-Carriage Isolates by Latex Agglutination, Whole-Genome Sequencing (PneumoCaT), and DNA Microarray in a High-Pneumococcal-Carriage-Prevalence Population in Malawi (2020)
Journal Article
Swarthout, T., Gori, A., Bar-Zeev, N., Kamng'ona, A., Mwalukomo, T., Bonomali, F., …French, N. (2021). Evaluation of Pneumococcal Serotyping of Nasopharyngeal-Carriage Isolates by Latex Agglutination, Whole-Genome Sequencing (PneumoCaT), and DNA Microarray in a High-Pneumococcal-Carriage-Prevalence Population in Malawi. Journal of Clinical Microbiology, 59(1), https://doi.org/10.1128/JCM.02103-20

Accurate assessment of the serotype distribution associated with pneumococcal colonization and disease is essential for evaluating and formulating pneumococcal vaccines and for informing vaccine policy. For this reason, we evaluated the concordance b... Read More about Evaluation of Pneumococcal Serotyping of Nasopharyngeal-Carriage Isolates by Latex Agglutination, Whole-Genome Sequencing (PneumoCaT), and DNA Microarray in a High-Pneumococcal-Carriage-Prevalence Population in Malawi.

Mining the Unmapped Reads in Bovine RNA-Seq Data Reveals the Prevalence of Bovine Herpes Virus-6 in European Dairy Cows and the Associated Changes in Their Phenotype and Leucocyte Transcriptome (2020)
Journal Article
Buggiotti, L., Cheng, Z., Wathes, C., & GplusE Consortium, G. (in press). Mining the Unmapped Reads in Bovine RNA-Seq Data Reveals the Prevalence of Bovine Herpes Virus-6 in European Dairy Cows and the Associated Changes in Their Phenotype and Leucocyte Transcriptome. Viruses, 12(12), 1451. https://doi.org/10.3390/v12121451

Microbial RNA is detectable in host samples by aligning unmapped reads from RNA sequencing against taxon reference sequences, generating a score proportional to the microbial load. An RNA-Seq data analysis showed that 83.5% of leukocyte samples from... Read More about Mining the Unmapped Reads in Bovine RNA-Seq Data Reveals the Prevalence of Bovine Herpes Virus-6 in European Dairy Cows and the Associated Changes in Their Phenotype and Leucocyte Transcriptome.

The Application of Bacteriophage Diagnostics for Bacterial Pathogens in the Agricultural Supply Chain: From Farm-to-Fork (2020)
Journal Article
Jones, H. J., Shield, C. G., & Swift, B. M. (2020). The Application of Bacteriophage Diagnostics for Bacterial Pathogens in the Agricultural Supply Chain: From Farm-to-Fork. PHAGE Therapy, Applications, and Research, 1(4), 176-188. https://doi.org/10.1089/phage.2020.0042

Bacteriophages (phages) have great potential not only as therapeutics but as diagnostics. Indeed, they have been developed and used to diagnose and detect bacterial infections, primarily in human clinical settings. The ability to rapidly detect and c... Read More about The Application of Bacteriophage Diagnostics for Bacterial Pathogens in the Agricultural Supply Chain: From Farm-to-Fork.

Incidence and risk factors for feline lymphoma in UK primary-care practice (2020)
Journal Article
Economu, L. (in press). Incidence and risk factors for feline lymphoma in UK primary-care practice. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13266

Objectives: The study aimed to estimate the incidence and prevalence of feline lymphoma in cats attending primary-care practices across the UK and to identify patient-based and environmental (radon and pesticide exposure) risk factors. Materials a... Read More about Incidence and risk factors for feline lymphoma in UK primary-care practice.

Association of immune responses of Zebu and Holstein?Friesian cattle and resistance to mycobacteria in a BCG challenge model (2020)
Journal Article
Alcaraz‐López, O. A., Flores‐Villalva, S., Cortéz‐Hernández, O., Vigueras‐Meneses, G., Carrisoza‐Urbina, J., Benítez‐Guzmán, A., …Gutiérrez‐Pabello, J. A. (in press). Association of immune responses of Zebu and Holstein‐Friesian cattle and resistance to mycobacteria in a BCG challenge model. Transboundary and Emerging Diseases, https://doi.org/10.1111/tbed.13939

Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation (2020)
Dataset
Cheng, Z., Wathes, D. C., Buggiotti, L., Salavati, M., Takeda, H., Tang, L., …Crowe, M. A. Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation. [Dataset]. https://doi.org/10.34840/q4vd-m506

Homeorhetic mechanisms assist dairy cows to transition from pregnancy to lactation. Less successful cows develop severe negative energy balance (NEB), placing them at risk of metabolic and infectious disease and reduced fertility. We have previously... Read More about Relationships between metabolic profiles and gene expression in liver and leukocytes of dairy cows in early lactation.

Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan (2020)
Journal Article
Elaagip, A., Alsedig, K., Altahir, O., Ageep, T., Ahmed, A., Siam, H. A., …Abdel Hamid, M. M. (in press). Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan. PLoS Neglected Tropical Diseases, 14(12), e0008918. https://doi.org/10.1371/journal.pntd.0008918

Dengue is a rapidly growing public health threat in Kassala state, eastern Sudan. The objective of this study was to determine the seroprevalence, entomological transmission indices, and socioeconomic risk factors associated with dengue in this regio... Read More about Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan.