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The Ecology of Pathogens Transmission at the Wildlife-Livestock Interface: Beyond Disease Ecology, Towards Socio-Ecological System Health (2021)
Book Chapter
De Garine-Wichatitsky, M., Miguel, E., Kock, R., Valls-Fox, H., & Caron, A. (2021). The Ecology of Pathogens Transmission at the Wildlife-Livestock Interface: Beyond Disease Ecology, Towards Socio-Ecological System Health. In C. Gortazar, K. Vercauteren, & J. Vicente (Eds.), Diseases at the Wildlife-Livestock Interface (91-119). https://doi.org/10.1007/978-3-030-65365-1_3

Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa (2021)
Book Chapter
Cheke, R., Little, K., Young, S., Walker, M., & Basanez, M. (2021). Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa. In R. Stothard, & D. Rollinson (Eds.), . https://doi.org/10.1016/bs.apar.2021.01.002

Onchocerciasis (also known as `river blindness'), is a neglected tropical disease (NTD) caused by the (Simulium-transmitted) filarial nematode Onchocerca volvulus. The occurrence of `blinding' (savannah) and non-blinding (forest) parasite strains and... Read More about Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa.

Effects of Heat Stress on Follicular Physiology in Dairy Cows (2021)
Journal Article
De Rensis, F., Saleri, R., Garcia-Ispierto, I., Scaramuzzi, R., & Lopez-Gatius, F. (2021). Effects of Heat Stress on Follicular Physiology in Dairy Cows. Animals, 11(12), https://doi.org/10.3390/ani11123406

Simple Summary Environmentally induced hyperthermia, also called heat stress (HS), compromises reproductive physiology in mammals. The number of oocytes is fixed after birth and they are stored in the ovary in a quiescent state (at the stage of the f... Read More about Effects of Heat Stress on Follicular Physiology in Dairy Cows.

Tracheal trauma and pneumonia secondary to endotracheal intubation in a horse undergoing general anaesthesia, computerised tomography and myelography (2021)
Journal Article
Díaz, M. D. M., Hewetson, M., & Kaartinen, J. (2021). Tracheal trauma and pneumonia secondary to endotracheal intubation in a horse undergoing general anaesthesia, computerised tomography and myelography. Equine Veterinary Education, n/a(n/a), https://doi.org/10.1111/eve.13591

Summary Endotracheal intubation is commonly performed in horses undergoing general anaesthesia to avoid fluid aspiration and provide mechanical ventilation and inhalational anaesthetic agents. Secondary laryngeal and tracheal trauma following intubat... Read More about Tracheal trauma and pneumonia secondary to endotracheal intubation in a horse undergoing general anaesthesia, computerised tomography and myelography.

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil (2021)
Journal Article
Faria, N., Mellan, T., Whittaker, C., Claro, I., Candido, D., Mishra, S., …Sabino, E. (2021). Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. Science, 372(6544), 815-+. https://doi.org/10.1126/science.abh2644

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 202... Read More about Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil.

Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study (2021)
Journal Article
Belay, M., Tulu, B., Younis, S., Jolliffe, D., Tayachew, D., Manwandu, H., …Martineau, A. (2021). Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study. The Lancet Microbe, 2(6), E267-E275. https://doi.org/10.1016/S2666-5247%2821%2900043-4

Background Haematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis complex DNA is d... Read More about Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study.

Trade-offs between individual and ensemble forecasts of an emerging infectious disease (2021)
Journal Article
Oidtman, R., Omodei, E., Kraemer, M., Castaneda-Orjuela, C., Cruz-Rivera, E., Misnaza-Castrillon, S., …Perkins, T. (2021). Trade-offs between individual and ensemble forecasts of an emerging infectious disease. Nature Communications, 12(1), https://doi.org/10.1038/s41467-021-25695-0

Newly emerged pathogens are inherently difficult to forecast, due to many unknowns about their biology early in an epidemic. Here, the authors assess forecasts of a suite of models during the Zika epidemic in Colombia, finding that the models that pe... Read More about Trade-offs between individual and ensemble forecasts of an emerging infectious disease.

Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence (2021)
Journal Article
COVID-19 Genomics UK COG-UK Consor, Kraemer, M., Hill, V., Ruis, C., Dellicour, S., Bajaj, S., …Pybus, O. (2021). Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence. Science, 373(6557), 889-+. https://doi.org/10.1126/science.abj0113

Understanding the causes and consequences of the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern is crucial to pandemic control yet difficult to achieve because they arise in the context of variable human... Read More about Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.

USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma (2021)
Journal Article
Ruiz, E., Pinto-Fernandez, A., Turnbull, A., Lan, L., Charlton, T., Scott, H., …Behrens, A. (2021). USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. eLife, 10, https://doi.org/10.7554/eLife.71596%3B+10.7554/eLife.71596.sa1%3B+10.7554/eLife.71596.sa2

Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP28... Read More about USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.

Molecular detection and genomic characterization of diverse hepaciviruses in African rodents (2021)
Journal Article
Bletsa, M., Vrancken, B., Gryseels, S., Boonen, I., Fikatas, A., Li, Y., …Lemey, P. (2021). Molecular detection and genomic characterization of diverse hepaciviruses in African rodents. Virus Evolution, 7(1), https://doi.org/10.1093/ve/veab036

Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins... Read More about Molecular detection and genomic characterization of diverse hepaciviruses in African rodents.

Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK (2021)
Journal Article
COVID-19 Gcnomics UK COG-UK Consor, du Plessis, L., McCrone, J., Zarebski, A., Hill, V., Ruis, C., …Pybus, O. (2021). Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK. Science, 371(6530), 708-+. https://doi.org/10.1126/science.abf2946

The United Kingdom's COVID-19 epidemic during early 2020 was one of world's largest and was unusually well represented by virus genomic sampling. We determined the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 sever... Read More about Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK.

Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe (2021)
Journal Article
Allerton, F., Prior, C., Bagcigil, A., Broens, E., Callens, B., Damborg, P., …Jessen, L. (2021). Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe. Antibiotics, 10(4), https://doi.org/10.3390/antibiotics10040409

Antimicrobial stewardship guidelines (ASGs) represent an important tool to help veterinarians optimize their antimicrobial use with the objective of decreasing antimicrobial resistance. The aim of this study was to map and qualitatively assess the AS... Read More about Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe.

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity (2021)
Journal Article
COG-UK Consortium, Volz, E., Hill, V., McCrone, J., Price, A., Jorgensen, D., …Connor, T. (2021). Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity. Cell, 184(1), 64-+. https://doi.org/10.1016/j.cell.2020.11.020

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the... Read More about Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula (2021)
Journal Article
PREPARE-VET Working Grp, ESCMID Study Grp Vet Microbiology, ESCMID Study Grp Antimicrobial ste, Espinosa-Gongora, C., Jessen, L., Dyar, O., …Guardabassi, L. (2021). Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula. Antibiotics, 10(4), https://doi.org/10.3390/antibiotics10040364

Education in antimicrobial stewardship (AMS) in veterinary medicine is essential to foster responsible antimicrobial use and control of antimicrobial resistance (AMR) in animals. AMS is listed by the EU and international organizations among the basic... Read More about Towards a Better and Harmonized Education in Antimicrobial Stewardship in European Veterinary Curricula.

Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic (2021)
Journal Article
COVID-19 Genomics UK COG-UK Consor, Jackson, B., Boni, M., Bull, M., Colleran, A., Colquhoun, R., …Rambaut, A. (2021). Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic. Cell, 184(20), 5179-+. https://doi.org/10.1016/j.cell.2021.08.014

We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1... Read More about Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic.

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation (2021)
Journal Article
Queval, C., Fearns, A., Botella, L., Smyth, A., Schnettger, L., Mitermite, M., …Gutierrez, M. (2021). Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation. PLoS Pathogens, 17(3), https://doi.org/10.1371/journal.ppat.1009410

The Mycobacterium tuberculosis complex (MTBC) is a group of related pathogens that cause tuberculosis (TB) in mammals. MTBC species are distinguished by their ability to sustain in distinct host populations. While Mycobacterium bovis (Mbv) sustains t... Read More about Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation.

The deubiquitylase USP9X controls ribosomal stalling (2021)
Journal Article
Clancy, A., Heride, C., Pinto-Fernandez, A., Elcocks, H., Kallinos, A., Kayser-Bricker, K., …Clague, M. (2021). The deubiquitylase USP9X controls ribosomal stalling. Journal of Cell Biology, 220(3), https://doi.org/10.1083/jcb.202004211

When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and... Read More about The deubiquitylase USP9X controls ribosomal stalling.

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities (2021)
Journal Article
Vaughan, D., Mitchell, R., Kretz, O., Chambers, D., Lalowski, M., Amthor, H., …Patel, K. (2021). A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities. Disease Models and Mechanisms, 14(2), https://doi.org/10.1242/dmm.047555

Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have been successfully developed to attenuate the signalling... Read More about A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.