Time-Kill Analysis of Canine Skin Pathogens: A Comparisonof Pradofloxacin and Marbofloxacin
(2023)
Journal Article
Pelligand, L., Mead, A., Toutain, P., Bond, R., & Azzariti, S. (2023). Time-Kill Analysis of Canine Skin Pathogens: A Comparisonof Pradofloxacin and Marbofloxacin. Antibiotics, https://doi.org/10.3390/antibiotics12101548
All Outputs (5)
Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens (2023)
Journal Article
Mead, A., Toutain, P., Richez, P., & Pelligand, L. (2023). Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens. Scientific Reports, 13, Article 12822. https://doi.org/10.1038/s41598-023-39727-wThe dosage of colistin for the treatment of enteric E. coli in animals necessitates considering the heteroresistant (HR) nature of the targeted inoculum, described by the presence of a major susceptible population (S1, representing 99.95% of total po... Read More about Targeted dosing for susceptible heteroresistant subpopulations may improve rational dosage regimen prediction for colistin in broiler chickens.
Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration (2023)
Journal Article
Schenk, I., Broussou, D., Roques, B., Lagershausen, H., Machnik, M., Röttgen, H., …Thevis, M. (2023). Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration. Drug Testing and Analysis, https://doi.org/10.1002/dta.3461
Doxycycline serum protein binding in pigs reveals a relatively high free fraction (2023)
Journal Article
Felipe Ramon, P., Marlène Z., L., Béatrice B., R., Véronique, G., Pierre-Louis, T., & Bousquet-Mélou, A. (2023). Doxycycline serum protein binding in pigs reveals a relatively high free fraction. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13111Doxycycline is an antibiotic widely used in pig farming, which leads to update the doses using PK/PD concepts. However, there is an impasse to estimate the PK/PD cut-off of doxycycline in pigs. Indeed, considering its 7% free fraction and the total s... Read More about Doxycycline serum protein binding in pigs reveals a relatively high free fraction.
Biased computation of Probability of Target Attainment for antimicrobial drugs (2023)
Journal Article
Toutain, P., Pelligand, L., Gandia, P., Ferran, A., Lees, P., Bousquet-Melou, A., & Concordet, D. (in press). Biased computation of Probability of Target Attainment for antimicrobial drugs. Clinical Pharmacology and Therapeutics,The medical literature is replete with articles in which there is confusion between “free concentration” and “free fraction” (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms... Read More about Biased computation of Probability of Target Attainment for antimicrobial drugs.