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All Outputs (27)

CD117 expression in canine ovarian tumours (2024)
Journal Article
Mallon, H., Ramírez, G., Dolensek, T., Erles, K., Martí-Garcia, B., Priestnall, S., & Suárez-Bonnet, A. (2024). CD117 expression in canine ovarian tumours. Journal of Comparative Pathology, 212, 1-5. https://doi.org/10.1016/j.jcpa.2024.05.001

Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase re... Read More about CD117 expression in canine ovarian tumours.

Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity (2024)
Journal Article
Then, C., Paillas, S., Moomin, A., Misheva, M., Moir, R., Hay, S., …Kiltie, A. (2024). Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity. Microbiome, 12(1), https://doi.org/10.1186/s40168-024-01804-1

Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota... Read More about Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

Endothelial AHR activity prevents lung barrier disruption in viral infection (2023)
Journal Article
Major, J., Crotta, S., Finsterbusch, K., Chakravarty, P., Shah, K., Frederico, B., …Wack, A. (2023). Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature, https://doi.org/10.1038/s41586-023-06287-y

Disruption of the lung endothelial-epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function(1). Endothelial dysfunction can exacerbate tissue damage... Read More about Endothelial AHR activity prevents lung barrier disruption in viral infection.

Urinary bladder hemangiosarcoma in a cat treated with partial cystectomy and adjuvant metronomic cyclophosphamide and thalidomide (2023)
Journal Article
McNally, A., Rossanese, M., Suárez‐Bonnet, A., Hardas, A., & Yale, A. D. (in press). Urinary bladder hemangiosarcoma in a cat treated with partial cystectomy and adjuvant metronomic cyclophosphamide and thalidomide. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16750

Visceral hemangiosarcomas (HSA) are rare in cats and typically associated with aggressive biologic behavior and poor prognosis. A 4-year-old male neutered domestic shorthair cat was presented with a 3-month history of hematuria and stranguria; ultras... Read More about Urinary bladder hemangiosarcoma in a cat treated with partial cystectomy and adjuvant metronomic cyclophosphamide and thalidomide.

Pathology and causes of death in captive meerkats (<i>Suricata suricatta</i>) (2023)
Journal Article
Martí-García, B., Priestnall, S., & Suárez-Bonnet, A. (2023). Pathology and causes of death in captive meerkats (Suricata suricatta). Veterinary Quarterly, 43(1), https://doi.org/10.1080/01652176.2023.2211120

Background Meerkats (Suricata suricatta) are endemic carnivores of southern Africa and, although currently listed as 'least concern' by the International Union for Conservation of Nature (IUCN) red list, there is evidence of a significant decrease in... Read More about Pathology and causes of death in captive meerkats (<i>Suricata suricatta</i>).

Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia (2023)
Journal Article
Glanemann, B., Humm, K., Szladovits, B., Abreu, M., Aspnall, S., Buckeridge, D., …Wilson, H. (in press). Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia. Journal of Veterinary Internal Medicine, 126-132. https://doi.org/10.1111/jvim.16613

Backgound: After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato- and myelotoxic mycotoxins T-2, HT-2 and
diac... Read More about Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia.

Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes (2022)
Journal Article
Berry, N., Ferguson, D., Kempster, S., Hall, J., Ham, C., Jenkins, A., …Almond, N. (2022). Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes. Scientific Reports, 12(1), https://doi.org/10.1038/s41598-022-23339-x

SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseline virological, molecular and pathologica... Read More about Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes.

Additional stains and immunohistochemistry: what else can the pathologist tell us? (2022)
Journal Article
Priestnall, S., & Suarez-Bonnet, A. (2022). Additional stains and immunohistochemistry: what else can the pathologist tell us?. In Practice, 44(7), 385-393. https://doi.org/10.1002/inpr.90

Background: For the veterinary pathologist, the 'bread and butter' of our work is the tissue slide stained with haematoxylin and eosin (H&E). This has long become globally recognised as the 'standard' stain, with haematoxylin highlighting the nuclei... Read More about Additional stains and immunohistochemistry: what else can the pathologist tell us?.

Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens (2022)
Journal Article
Oros, J., Priestnall, S., & Suarez-Bonnet, A. (2022). Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens. Diseases of Aquatic Organisms, 151, 23-27. https://doi.org/10.3354/dao03686

Intensive breeding of the Siamese fighting fish Betta splendens, a species that inhabits marshlands in Thailand and other countries in south-east Asia, was traditionally focused on game fighting because the males are very territorial, but has evolved... Read More about Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens.

Correlation between magnetic resonance imaging and histological lesions in a case of meningoencephalomyelitis secondary to Neospora caninum infection in a greyhound (2022)
Journal Article
Albertini, G., Stabile, F., Yaffy, D., Suaez-Bonnet, A., & Uriarte, A. (2022). Correlation between magnetic resonance imaging and histological lesions in a case of meningoencephalomyelitis secondary to Neospora caninum infection in a greyhound. Vet Record Case Reports, https://doi.org/10.1002/vrc2.440

An 11-year-old, male, neutered raw fed greyhound was presented for a 2-week history of progressive non-lateralised, non-painful ambulatory paraparesis, deteriorating acutely to non-ambulatory tetraparesis. Magnetic resonance imaging, cerebrospinal fl... Read More about Correlation between magnetic resonance imaging and histological lesions in a case of meningoencephalomyelitis secondary to Neospora caninum infection in a greyhound.

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy (2021)
Journal Article
Tajan, M., Hennequart, M., Cheung, E., Zani, F., Hock, A., Legrave, N., …Vousden, K. (2021). Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12(1), https://doi.org/10.1038/s41467-020-20223-y

Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, includi... Read More about Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.

Pulmonary mass-like lesion caused by Toxoplasma gondii in a domestic shorthair cat (2021)
Journal Article
McKenna, M., Augusto, M., Suarez-Bonnet, A., & Fitzgerald, E. (2021). Pulmonary mass-like lesion caused by Toxoplasma gondii in a domestic shorthair cat. Journal of Veterinary Internal Medicine, 35(3), 1547-1550. https://doi.org/10.1111/jvim.16111

A 2-year-old male neutered domestic shorthair cat underwent investigations for acute onset of lethargy, hyporexia, and cough. Computed tomography of the thorax identified a large mass-like lesion in the left cranial lung lobe and bilateral pleural ef... Read More about Pulmonary mass-like lesion caused by Toxoplasma gondii in a domestic shorthair cat.

COMPARATIVE EVALUATION OF THE KOMODO DRAGON (Varanus komodoensis) AND THE GREEN IGUANA (Iguana iguana) SKULL BY THREE-DIMENSIONAL COMPUTED TOMOGRAPHIC RECONSTRUCTION (2021)
Journal Article
Perez, S., Encinoso, M., Morales, M., Arencibia, A., Suarez-Bonnet, A., Gonzalez-Rodriguez, E., & RaduanJaber, J. (2021). COMPARATIVE EVALUATION OF THE KOMODO DRAGON (Varanus komodoensis) AND THE GREEN IGUANA (Iguana iguana) SKULL BY THREE-DIMENSIONAL COMPUTED TOMOGRAPHIC RECONSTRUCTION. Slovenian Veterinary Research, 58(3), 111-116. https://doi.org/10.26873/SVR-1330-2021

The purpose of this paper was to do a comparative evaluation of the skull of two species of lizards, the Komodo dragon (Varanus komodoensis) and the Green Iguana ( Iguana iguana), by three-dimensional computed tomographic reconstruction. Images provi... Read More about COMPARATIVE EVALUATION OF THE KOMODO DRAGON (Varanus komodoensis) AND THE GREEN IGUANA (Iguana iguana) SKULL BY THREE-DIMENSIONAL COMPUTED TOMOGRAPHIC RECONSTRUCTION.

Diagnosis, treatment and postsurgical complications in a dog with epileptic seizures and a naso-ethmoidal meningoencephalocele (2021)
Journal Article
Mojarradi, A., Van Meervenne, S., Suarez-Bonnet, A., & De Decker, S. (2021). Diagnosis, treatment and postsurgical complications in a dog with epileptic seizures and a naso-ethmoidal meningoencephalocele. Acta Veterinaria Scandinavica, 63(1), https://doi.org/10.1186/s13028-021-00591-1

Background Naso-ethmoidal meningoencephalocele is usually a congenital anomaly consisting of a protrusion of cerebral tissue and meninges into the ethmoidal labyrinth. The condition is a rare cause of structural epilepsy in dogs. We report the clinic... Read More about Diagnosis, treatment and postsurgical complications in a dog with epileptic seizures and a naso-ethmoidal meningoencephalocele.

Canine tonsillar polyps: characteristics, classification and review of the pathogenesis (2020)
Journal Article
Molin, J., Vilafranca Compte, M., Suárez-Bonnet, A., Altimira, J., & Ramírez, G. (2020). Canine tonsillar polyps: characteristics, classification and review of the pathogenesis. Veterinary Pathology,

Canine tonsillar polyps are uncommon. We describe 14 tonsillar polyps in dogs and review their classification and pathogenesis. All dogs were adult (3-13 years old). Females (10/14) were more affected than males (4/14). Most of the lesions were asymp... Read More about Canine tonsillar polyps: characteristics, classification and review of the pathogenesis.

High-Grade Cutaneous Mast Cell Tumour with Widespread Intrathoracic Metastasis and Neoplastic Pericardial Effusion in a Dog (2020)
Journal Article
Yale, A. D., Szladovits, B., Stell, A., Fitzgerald, S. D., Priestnall, S. L., & Suarez-Bonnet, A. (2020). High-Grade Cutaneous Mast Cell Tumour with Widespread Intrathoracic Metastasis and Neoplastic Pericardial Effusion in a Dog. Journal of Comparative Pathology, 180, 29-34

An 8-year-old neutered male French Bulldog was presented with a 2-day history of intermittent vomiting, reduced appetite and recent rapid development of multiple cutaneous masses over the head and neck regions. On presentation, the patient had a mode... Read More about High-Grade Cutaneous Mast Cell Tumour with Widespread Intrathoracic Metastasis and Neoplastic Pericardial Effusion in a Dog.

Scent (Apocrine) Gland Adenocarcinoma in a Wedge-Capped Capuchin Monkey (Cebus olivaceus): Histological and Immunohistochemical Features. (2020)
Journal Article
Suárez-Bonnet, A., Priestnall, S. L., Ramírez, G. A., González-Sánchez, C., & Jaber, J. R. (2020). Scent (Apocrine) Gland Adenocarcinoma in a Wedge-Capped Capuchin Monkey (Cebus olivaceus): Histological and Immunohistochemical Features. Journal of Comparative Pathology, 179, 1-6

In humans, apocrine gland tumours encompass a heterogeneous group of uncommon neoplasms with varied and unpredictable biological behaviour. They can be slow-growing lesions, recur after excision, produce lymph node metastasis in up to 50% of cases or... Read More about Scent (Apocrine) Gland Adenocarcinoma in a Wedge-Capped Capuchin Monkey (Cebus olivaceus): Histological and Immunohistochemical Features..

Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease (2020)
Journal Article
Farray, D., Rodriguez, F., Ravelo-Garcìa, A., Suarez-Bonne, A., Francisco-Arteaga, C., & Jaber, J. R. (2020). Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease

This paper compares the correlation between the clinical signs and the histopathological observations of the entire intestine in cats and dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 53 dogs and 20 cats of di... Read More about Investigation of correlations between clinical signs and pathological findings in cats and dogs with inflammatory bowel disease.