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Effect of pituitary-dependent hypercortisolism on the survival of dogs treated with radiotherapy for pituitary macroadenomas (2023)
Journal Article
Rapastella, S., Morabito, S., Sharman, M., Benoit, J., Schiavo, L., Morris, J., …Scudder, C. (2023). Effect of pituitary-dependent hypercortisolism on the survival of dogs treated with radiotherapy for pituitary macroadenomas. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16724

BackgroundRadiotherapy (RT) is an effective treatment for dogs presented with neurologic signs caused by pituitary tumors. However, its impact on the outcome of concurrent pituitary-dependent hypercortisolism (PDH) is controversial. ObjectivesDetermi... Read More about Effect of pituitary-dependent hypercortisolism on the survival of dogs treated with radiotherapy for pituitary macroadenomas.

Antibiotic therapy in dogs and cats in general practise in the United Kingdom before referral (2023)
Journal Article
Bravo, R., Sharman, M., Raj, J., & Scudder, C. (2023). Antibiotic therapy in dogs and cats in general practise in the United Kingdom before referral. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13615

Objectives To describe antibiotic prescription by veterinarians in general practises in the United Kingdom before referral and analyse if UK antibiotic stewardship guidelines were followed.Materials and Methods The clinical records from dogs and cats... Read More about Antibiotic therapy in dogs and cats in general practise in the United Kingdom before referral.

Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus (2020)
Journal Article
Scudder, C. J., Hazuchova, K., Gostelow, R., Church, D. B., Forcada, Y., Fowkes, R. C., & Niessen, S. J. M. (2020). Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus. Journal of Feline Medicine and Surgery, 1098612X2093321. https://doi.org/10.1177/1098612X20933213

Abstract Objectives An affordable and effective treatment is needed to manage feline hypersomatotropism. The aim of this study was to assess whether treatment with oral cabergoline for 90 days in cats with hypersomatotropism and diabetes mellitus i... Read More about Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus.

Suspected congenital hyperinsulinism in a Shiba Inu dog (2020)
Journal Article
Cook, S., McKenna, M., Glanemann, B., Sandhu, R., & Scudder, C. (2020). Suspected congenital hyperinsulinism in a Shiba Inu dog. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15834

A 3-month-old male intact Shiba Inu dog was evaluated for a seizure disorder initially deemed idiopathic in origin. Seizure frequency remained unchanged despite thera- peutic serum phenobarbital concentration and use of levetiracetam. The dog was doc... Read More about Suspected congenital hyperinsulinism in a Shiba Inu dog.

Pituitary pathology and gene expression in acromegalic cats (2019)
Journal Article
Scudder, C. J., Mirczuk, S. M., Richardson, K. M., Crossley, V. J., Regan, J. T. C., Gostelow, R., …Niessen, S. J. M. (2019). Pituitary pathology and gene expression in acromegalic cats. Journal of the Endocrine Society, 3(1), 181-200. https://doi.org/10.1210/js.2018-00226

The prevalence of growth hormone secreting pituitary tumours in domestic cats (Felis catus) is ten times greater than in humans. The predominant inhibitory receptors of growth hormone-secreting pituitary tumours are somatostatin receptors (SSTRs) and... Read More about Pituitary pathology and gene expression in acromegalic cats.

Prospective evaluation of a protocol for transitioning porcine lente insulintreated diabetic cats to human recombinant protamine zinc insulin (2018)
Journal Article
Gostelow, R., Hazuchova, K., Scudder, C., Forcada, Y., Church, D. B., & Niessen, S. J. M. (2018). Prospective evaluation of a protocol for transitioning porcine lente insulintreated diabetic cats to human recombinant protamine zinc insulin. Journal of Feline Medicine and Surgery, 20(2), 114-121. https://doi.org/10.1177/1098612X17697482

Objectives The objective was to evaluate a nadir-led protocol for transitioning porcine lente insulin suspension (PLIS)-treated diabetic cats onto human recombinant protamine zinc insulin (PZIR). Methods Recently diagnosed (

Acceptance of home blood glucose monitoring by owners of recently diagnosed diabetic cats and impact on quality of life changes in cat and owner (2017)
Journal Article
Hazuchova, K., Gostelow, R., Scudder, C. J., Forcada, Y., Church, D. B., & Niessen, S. J. M. (2017). Acceptance of home blood glucose monitoring by owners of recently diagnosed diabetic cats and impact on quality of life changes in cat and owner. Journal of Feline Medicine and Surgery, 20(8), 711-720. https://doi.org/10.1177/1098612X17727692

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene (2017)
Journal Article
Scudder, C. J., Niessen, S. J. M., Catchpole, B., Fowkes, R. C., Church, D. B., & Forcada, Y. (2017). Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene. Domestic Animal Endocrinology, 59, 134-139. https://doi.org/10.1016/j.domaniend.2016.11.005

Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene. Feline acromegaly has similarities to human... Read More about Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene.

Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines
Journal Article
Mirczuk, S. M., Lessey, A. J., Catterick, A. R., Perrett, R. M., Scudder, C. J., Read, J. E., …Fowkes, R. C. (in press). Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines. Cells, 8(9), https://doi.org/10.3390/cells8091086

C-type natriuretic peptide (CNP) is the most conserved member of the mammalian natriuretic peptide family, and is implicated in the endocrine regulation of growth, metabolism and reproduction. CNP is expressed throughout the body, but is particularly... Read More about Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines.