Skip to main content

Research Repository

Advanced Search

Browse


Use of precision-cut tissue slices as a translational model to study host-pathogen and vaccine assessment (2021)
Journal Article
Majorova, D., Atkins, E., Martineau, H., Vokral, I., Oosterhuis, D., Olinga, P., …Werling, D. Use of precision-cut tissue slices as a translational model to study host-pathogen and vaccine assessment. Manuscript submitted for publication

The recent increase in new technologies to analyse host-pathogen interaction has fostered a race to develop new methodologies to assess these not only on the cellular level, but also on the tissue level. Due to mouse-other mammal differences, there i... Read More about Use of precision-cut tissue slices as a translational model to study host-pathogen and vaccine assessment.

Cellular and Cytokine Responses in the Granulomas of Asymptomatic Cattle naturally infected with (2020)
Journal Article
Tulu, B., Martineau, H. M., Zewude, A., Desta, F., Jolliffe, D. A., Abebe, M., …Ameni, G. (2020). Cellular and Cytokine Responses in the Granulomas of Asymptomatic Cattle naturally infected with. Infection and Immunity,

Cells (CD3+ T cell and CD68+ macrophages), cytokines (IFN-γ+ and TNF-α+) and effector molecule (iNOS+) responses were evaluated in the lymph nodes and tissue of cattle naturally infected with Detailed post mortem and immunohistochemical examination... Read More about Cellular and Cytokine Responses in the Granulomas of Asymptomatic Cattle naturally infected with.

Genetic diversity and population structure of Angiostrongylus vasorum parasites within and between local urban foxes (Vulpes Vulpes) (2018)
Journal Article
Blanch-Lazaro, B., Mitton, Z., Tudor, C., Hindle, J., Martineau, H., Fox, M. T., & Blake, D. P. (2018). Genetic diversity and population structure of Angiostrongylus vasorum parasites within and between local urban foxes (Vulpes Vulpes). Veterinary Parasitology, 262, 42-46. https://doi.org/10.1016/j.vetpar.2018.09.008

Angiostrongylus vasorum is a nematode parasite of the pulmonary arteries and heart that infects domestic and wild canids. Dogs (Canis familiaris) and red foxes (Vulpes vulpes) are the most commonly affected definitive hosts. Recent studies suggest th... Read More about Genetic diversity and population structure of Angiostrongylus vasorum parasites within and between local urban foxes (Vulpes Vulpes).

Canine NAPEPLD-associated models of human myelin disorders (2018)
Journal Article
Minor, K. M., Letko, A., Becker, D., Drogemuller, M., Mandigers, P. J. J., Bellekom, S. R., …Drogemuller, C. (2018). Canine NAPEPLD-associated models of human myelin disorders. https://doi.org/10.1038/s41598-018-23938-7

Canine leukoencephalomyelopathy (LEMP) is a juvenile-onset neurodegenerative disorder of the CNS white matter currently described in Rottweiler and Leonberger dogs. Genome-wide association study (GWAS) allowed us to map LEMP in a Leonberger cohort to... Read More about Canine NAPEPLD-associated models of human myelin disorders.

Saigas on the brink: Multidisciplinary analysis of the factors influencing mass mortality events (2018)
Journal Article
Kock, R. A., Orynbayev, M., Robinson, S., Zuther, S., Singh, N. J., Beauvais, W., …Milner-Gulland, E. (2018). Saigas on the brink: Multidisciplinary analysis of the factors influencing mass mortality events. Science Advances, 4(1), https://doi.org/10.1126/sciadv.aao2314

In 2015, more than 200,000 saiga antelopes died in 3 weeks in central Kazakhstan. The proximate cause of death is confirmed as hemorrhagic septicemia caused by the bacterium Pasteurella multocida type B, based on multiple strands of evidence. Statist... Read More about Saigas on the brink: Multidisciplinary analysis of the factors influencing mass mortality events.

Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo (2015)
Journal Article
Patterson, R., Eley, T. S., Browne, C., Martineau, H. M., & Werling, D. (2015). Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo. Vaccine, 33(46), 6199-205. https://doi.org/10.1016/j.vaccine.2015.10.003

Porcine circovirus type 2 (PCV2) is now endemic in every major pig producing country, causing PCV-associated disease (PCVAD), linked with large scale economic losses. Current vaccination strategies are based on the capsid protein of the virus and are... Read More about Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo.

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b (2015)
Journal Article
Patterson, R., Nevel, M., Diaz, A. V., Martineau, H. M., Demmers, T. G. M., Browne, C., …Werling, D. (2015). Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b. Veterinary Microbiology, 177(3-4), 261-269. https://doi.org/10.1016/j.vetmic.2015.03.010

Porcine circovirus type 2 (PCV2) has been identified as the essential, but not sole, underlying infectious component for PCV-associated diseases (PCVAD). Several co-factors have been suggested to convert an infection with PCV2 into the clinical signs... Read More about Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.