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All Outputs (53)

The lymphatic filariasis treatment study landscape: A systematic review of study characteristics and the case for an individual participant data platform (2024)
Journal Article
Freitas, L. T., Khan, M. A., Uddin, A., Halder, J. B., Singh-Phulgenda, S., Raja, J. D., …Srividya, A. (in press). The lymphatic filariasis treatment study landscape: A systematic review of study characteristics and the case for an individual participant data platform. PLoS Neglected Tropical Diseases, 18(1), e0011882. https://doi.org/10.1371/journal.pntd.0011882

Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa? (2023)
Journal Article
Kura, K., Milton, P., Hamley, J., Walker, M., Bakajika, D., Kanza, E., …Basáñez, M. (2023). Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?. Philosophical Transactions of the Royal Society B: Biological Sciences, 378(1887), https://doi.org/10.1098/rstb.2022.0277

Epidemiological and modelling studies suggest that elimination of Onchocerca volvulus transmission (EoT) throughout Africa may not be achievable with annual mass drug administration (MDA) of ivermectin alone, particularly in areas of high endemicity... Read More about Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?.

Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective (2023)
Journal Article
Diaz, A., Walker, M., & Webster, J. (2023). Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective. Philosophical Transactions of the Royal Society B: Biological Sciences, 378(1887), https://doi.org/10.1098/rstb.2022.0274

The past three years has seen the launch of a new World Health Organization (WHO) neglected tropical diseases (NTDs) roadmap, together with revised control and elimination guidelines. Across all, there is now a clear emphasis on the need to incorpora... Read More about Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective.

Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis (2023)
Journal Article
Calvo-Urbano, B., Leger, E., Gabain, I., De Dood, C., Diouf, N., Borlase, A., …Webster, J. (2023). Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis. PLoS Neglected Tropical Diseases, 17(5), https://doi.org/10.1371/journal.pntd.0010739

Schistosomiasis is a major neglected tropical disease (NTD) affecting both humans and animals. The morbidity and mortality inflicted upon livestock in the Afrotropical region has been largely overlooked, in part due to a lack of validated sensitive a... Read More about Sensitivity and specificity of human point-of-care circulating cathodic antigen (POC-CCA) test in African livestock for rapid diagnosis of schistosomiasis: A Bayesian latent class analysis.

Modelling the control of bovine brucellosis in India (2023)
Journal Article
Holt, H., Walker, M., Beauvais, W., Kaur, P., Bedi, J., Mangtani, P., …Guitian, J. (2023). Modelling the control of bovine brucellosis in India. Journal of the Royal Society, Interface, 20(200), https://doi.org/10.1098/rsif.2022.0756

Brucellosis imposes substantial impacts on livestock production and public health worldwide. A stochastic, age-structured model incorporating herd demographics was developed describing within- and between-herd transmission of Brucella abortus in dair... Read More about Modelling the control of bovine brucellosis in India.

Modeling the effectiveness of One Health interventions against the zoonotic hookworm Ancylostoma ceylanicum (2023)
Journal Article
Walker, M., Lambert, S., Neves, M., Worsley, A., Traub, R., & Colella, V. (2023). Modeling the effectiveness of One Health interventions against the zoonotic hookworm Ancylostoma ceylanicum. Frontiers in Medicine, 10, https://doi.org/10.3389/fmed.2023.1092030

Hookworm disease is a major global public health concern, annually affecting 500-700 million of the world's poorest people. The World Health Organization is targeting the elimination of hookworm as a public health problem by 2030 using a strategy of... Read More about Modeling the effectiveness of One Health interventions against the zoonotic hookworm Ancylostoma ceylanicum.

Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites (2022)
Journal Article
Willen, L., Milton, P., Hamley, J., Walker, M., Osei-Atweneboana, M., Volf, P., …Courtenay, O. (2022). Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites. PLoS Neglected Tropical Diseases, 16(1), https://doi.org/10.1371/journal.pntd.0010108

BackgroundIn onchocerciasis endemic areas in Africa, heterogenous biting rates by blackfly vectors on humans are assumed to partially explain age- and sex-dependent infection patterns with Onchocerca volvulus. To underpin these assumptions and furthe... Read More about Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites.

Is the incidence of congenital toxoplasmosis declining? (2022)
Journal Article
Milne, G., Webster, J., & Walker, M. (2022). Is the incidence of congenital toxoplasmosis declining?. Trends in Parasitology, 39(1), 26-37. https://doi.org/10.1016/j.pt.2022.10.003

Prenatal infection with the protozoan parasite Toxoplasma gondii can cause con-genital toxoplasmosis (CT), an often fatal or lifelong-disabling condition. Several studies of human populations have reported temporal decreases in seroprevalence, sugges... Read More about Is the incidence of congenital toxoplasmosis declining?.

Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands (2022)
Journal Article
Pennance, T., Neves, M. I., Webster, B. L., Gower, C. M., Knopp, S., Khamis, I. S., …Webster, J. P. (2022). Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands. PLoS Neglected Tropical Diseases, 16(10), e0010419. https://doi.org/10.1371/journal.pntd.0010419

Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance (2022)
Journal Article
Díaz, A. V., Lambert, S., Neves, M. I., Borlase, A., Léger, E., Diouf, N. D., …Walker, M. (2022). Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance. Frontiers in Tropical Diseases, 3, 1-12. https://doi.org/10.3389/fitd.2022.893066

Schistosomiasis, a neglected tropical disease, is a widespread chronic helminthiasis reported in 78 countries, predominantly those within sub-Saharan Africa, as well as Latin America, Asia, and most recently, even Europe. Species of the causative blo... Read More about Modelling livestock test-and-treat: A novel One Health strategy to control schistosomiasis and mitigate drug resistance.

Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis (2022)
Journal Article
Dixon, M., Winskill, P., Harrison, W., Whittaker, C., Schmidt, V., Sanchez, A., …Basanez, M. (2022). Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis. eLife, 11, https://doi.org/10.7554/eLife.76988

Infection by Taenia solium poses a major burden across endemic countries. The World Health Organization (WHO) 2021-2030 Neglected Tropical Diseases roadmap has proposed that 30% of endemic countries achieve intensified T. solium control in hyperendem... Read More about Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis.

Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data (2022)
Journal Article
Walker, M., Freitas, L. T., Halder, J. B., Brack, M., Keiser, J., King, C. H., …Basáñez, M. (in press). Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data. Wellcome Open Research, 7, 5. https://doi.org/10.12688/wellcomeopenres.17468.1

Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa (2021)
Book Chapter
Cheke, R., Little, K., Young, S., Walker, M., & Basanez, M. (2021). Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa. In R. Stothard, & D. Rollinson (Eds.), . https://doi.org/10.1016/bs.apar.2021.01.002

Onchocerciasis (also known as `river blindness'), is a neglected tropical disease (NTD) caused by the (Simulium-transmitted) filarial nematode Onchocerca volvulus. The occurrence of `blinding' (savannah) and non-blinding (forest) parasite strains and... Read More about Taking the strain out of onchocerciasis? A reanalysis of blindness and transmission data does not support the existence of a savannah blinding strain of onchocerciasis in West Africa.

Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective (2021)
Journal Article
Diaz, A., Walker, M., & Webster, J. (2021). Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective. Evolutionary Applications, https://doi.org/10.1111/eva.13310

The relevance of mustelids in SARS-CoV-2 transmission has become increasingly evident. Alongside experimental demonstration of airborne transmission among ferrets, the major animal model for human respiratory diseases, transmission of SARS-CoV-2 with... Read More about Surveillance and control of SARS-CoV-2 in mustelids: An evolutionary perspective.

Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure (2021)
Journal Article
Walker, M., Cools, P., Albonico, M., Ame, S. M., Ayana, M., Dana, D., …Levecke, B. (in press). Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. PLoS Neglected Tropical Diseases, 15(10), e0009888. https://doi.org/10.1371/journal.pntd.0009888

Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends (2020)
Journal Article
Dixon, M. A., Winskill, P., Harrison, W. E., Whittaker, C., Schmidt, V., Sarti, E., …Basáñez, M. G. (2020). Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends. Scientific Reports, 10(1), 17637

Abstract: The World Health Organization (WHO) called, in 2012, for a validated strategy towards Taenia solium taeniasis/cysticercosis control and elimination. Estimating pig force-of-infection (FoI, the average rate at which susceptible pigs become i... Read More about Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends.