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Metformin and empagliflozin combination modulate macrophage inflammatory gene expression (2023)
Journal Article
Arefin, A., & Gage, M. C. (2023). Metformin and empagliflozin combination modulate macrophage inflammatory gene expression. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24054785

Type-2 Diabetes Mellitus is a complex, chronic illness characterized by persistent high blood glucose levels. Patients can be described anti diabetes drugs as single agents or in combination depending on the severity of their condition. Metformin and... Read More about Metformin and empagliflozin combination modulate macrophage inflammatory gene expression.

The immunomodulatory effects of statins on macrophages Author information (2022)
Journal Article
Sheridan, A., Wheeler-Jones, C., & Gage, M. C. (2022). The immunomodulatory effects of statins on macrophages Author information. Immuno, https://doi.org/10.3390/immuno2020021

Statins are extensively used in the medical practice, with their action as lipid-lowering agents proving to be central in the treatment of atherosclerotic cardiovascular disease. However, in addition to their cholesterol-reducing effects, mounting ev... Read More about The immunomodulatory effects of statins on macrophages Author information.

Challenges and solutions for diabetes early career researchers in the COVID-19 recovery – perspectives of the Diabetes UK Innovators in Diabetes (2021)
Journal Article
Gage, M. (in press). Challenges and solutions for diabetes early career researchers in the COVID-19 recovery – perspectives of the Diabetes UK Innovators in Diabetes. Diabetic Medicine, https://doi.org/10.1111/dme.14698

The COVID-19 pandemic has put diabetes at the forefront of conversation. The prevalence of type 2 diabetes in the UK is high1 and has links to adverse COVID-19 outcomes2. Research investigating the links between these two public health issues are mov... Read More about Challenges and solutions for diabetes early career researchers in the COVID-19 recovery – perspectives of the Diabetes UK Innovators in Diabetes.

Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., …Pineda-Torra, I. (2018). Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proceedings of the National Academy of Sciences, 115(28), E6556-E6565. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., …Pineda-Torra, I. (2018). Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance (2017)
Journal Article
Watt, N. T., Gage, M. C., Patel, P. A., Viswambharan, H., Sukumar, P., Galloway, S., …Cubbon, R. M. (2017). Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance. Diabetes, 66(11), 2808-2821. https://doi.org/10.2337/db17-0062

Shc homology 2–containing inositol 5′ phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endothel... Read More about Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance.

The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms
Journal Article
Pourcet, B., Gage, M. C., Leon, T. E., Waddington, K. E., Pello, O. M., Steffensen, K. R., …Pineda-Torra, I. (in press). The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms. https://doi.org/10.1038/srep25481

IL-18 is a member of the IL-1 family involved in innate immunity and inflammation. Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including inflammatory and metabolic diseases, yet relatively little is known regard... Read More about The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms.

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype
Journal Article
Yuldasheva, N. Y., Rashid, S. T., Haywood, N. J., Cordell, P., Mughal, R., Viswambharan, H., …Wheatcroft, S. B. (in press). Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(9), 2051-8. https://doi.org/10.1161/ATVBAHA.114.304121