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Evaluation Of Presentation Treatment And Outcome In Hypertensive Emergency in dogs and cats: 15 cases (2003-2019) (2022)
Journal Article
Beeston, D., Jepson, R., & Cortellini, S. (2022). Evaluation Of Presentation Treatment And Outcome In Hypertensive Emergency in dogs and cats: 15 cases (2003-2019). Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13530

Title: Evaluation of presentation, treatment and outcome in hypertensive emergency in dogs and cats: 15 cases (2003-2019). Introduction: Hypertensive emergency (HE) is well-recognised in human medicine, yet there is limited veterinary evidence. This... Read More about Evaluation Of Presentation Treatment And Outcome In Hypertensive Emergency in dogs and cats: 15 cases (2003-2019).

Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass (2022)
Journal Article
Starybrat, D., Jepson, R., Bristow, P., Peterson, S., Yerramilli, M., Yerramilli, M., …Cortellini, S. (in press). Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass. Journal of Veterinary Emergency and Critical Care,

Objective - Assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. Design – Prospective cohort st... Read More about Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.

First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats (2022)
Journal Article
Jepson, R. E., Warren, H., Syme, H. M., Elliott, J., & Munroe, P. B. (2022). First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats. Scientific Reports, https://doi.org/10.1038/s41598-022-05494-3

Hypertension (HTN) and chronic kidney disease (CKD) are common in ageing cats. In humans, blood pressure (BP) and renal function are complex heritable traits. We performed the first feline Genome-Wide Association Study (GWAS) of quantitative traits s... Read More about First Genome-Wide Association Study Investigating Blood Pressure and Renal Traits in Domestic Cats.

Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease (2020)
Journal Article
Jepson, R., Elliott, J., Geddes, R., Chang, Y., & Tang, P. (2020). Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 1-12. https://doi.org/10.1111/jvim.15996

Background Dietary phosphate restriction improves survival in cats with chronic kidney disease (CKD). However, feeding a phosphate‐restricted diet may disrupt calcium homeostasis leading to hypercalcemia in some cats. Objectives To identify... Read More about Risk factors associated with disturbances of calcium homeostasis after initiation of a phosphate-restricted diet in cats with chronic kidney disease.

Dysautonomia in 53 cats and dogs: retrospective review of clinical data and outcome (2020)
Journal Article
Clarke, K. E., Sorrell, S., Breheny, C., Jepson, R. E., Adamantos, S., Milne, E. M., & Gunn-moore, D. (2020). Dysautonomia in 53 cats and dogs: retrospective review of clinical data and outcome. Veterinary Record, https://doi.org/10.1136/vr.105258

The aim of this study was to perform a retrospective multicentre review of clinical data relating to cats and dogs diagnosed with dysautonomia and to evaluate their outcome.

ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats (2018)
Journal Article
Acierno, M. J., Brown, S., Coleman, A. E., Jepson, R. E., Papich, M., Stepien, R. L., & Syme, H. M. (2018). ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15331

An update to the 2007 American College of Veterinary Internal Medicine (ACVIM) consensus statement on the identification, evaluation, and management of systemic hypertension in dogs and cats was presented at the 2017 ACVIM Forum in National Harbor, M... Read More about ACVIM consensus statement: Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats.

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK (2018)
Journal Article
Stevens, K. B., O'Neill, D. G., Jepson, R. E., Holm, L. P., Walker, D. J., & Cardwell, J. M. (2018). Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK. Veterinary Record, 183(14), 448. https://doi.org/10.1136/vr.104891

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an incre... Read More about Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK.

Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK (2018)
Journal Article
Stevens, K. B., Jepson, R. E., Holm, L. P., Walker, D. J., & Cardwell, J. M. (2018). Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK. Veterinary Record, 183(16), 502. https://doi.org/10.1136/vr.104892

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an incre... Read More about Spatio-temporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK.

Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy (2018)
Journal Article
Skulberg, R., Cortellini, S., Chan, D. L., Giacomo, S., & Jepson, R. E. (2018). Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy. Frontiers in Veterinary Science, 5(161), https://doi.org/10.3389/fvets.2018.00161

Cutaneous and renal glomerular vasculopathy (CRGV) is a rare disease affecting dogs, with a recent apparent increase in prevalence since 2012 in the UK. This disease is characterized by a vasculopathy affecting small vessels of the kidney and skin, l... Read More about Description of the use of plasma exchange in dogs with Cutaneous and Renal Glomerular Vasculopathy.

Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease (2018)
Journal Article
Van Den Broek, D. H. N., Geddes, R. F., Williams, T. L., Chang, Y. M., Elliott, J., & Jepson, R. E. (2018). Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease. Journal of Veterinary Internal Medicine, 32(2), 727-735. https://doi.org/10.1111/jvim.15051

Background: Hypercalcemia is commonly associated with chronic kidney disease (CKD) in cats. Objectives: To explore the calcitonin response to naturally occurring ionized hypercalcemia in cats with azotemic CKD, and to assess the relationship of... Read More about Calcitonin Response to Naturally Occurring Ionized Hypercalcemia in Cats with Chronic Kidney Disease.

Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats (2018)
Journal Article
Geddes, R. F., Jepson, R. E., Forcada, Y., Elliott, J., & Syme, H. M. (2018). Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats. https://doi.org/10.1016/j.tvjl.2018.02.010

Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nuc... Read More about Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats.

Systemic hypertension in cats with acute kidney injury (2017)
Journal Article
Cole, L., Jepson, R. E., & Humm, K. R. (2017). Systemic hypertension in cats with acute kidney injury. Journal of Small Animal Practice, 58(10), 577-581. https://doi.org/10.1111/jsap.12726

Retrospective study of cats presenting to the Queen Mother Hospital for Animals, Royal Veterinary College with acute kidney injury between 2007 and 2015. Systolic blood pressure was measured using Doppler sphygmomanometry and systemic hypertension wa... Read More about Systemic hypertension in cats with acute kidney injury.

Plasma N-Terminal Probrain Natriuretic Peptide, Vascular Endothelial Growth Factor, and Cardiac Troponin I as Novel Biomarkers of Hypertensive Disease and Target Organ Damage in Cats (2017)
Journal Article
Bijsmans, E. S., Jepson, R. E., Wheeler, C., Syme, H. M., & Elliott, J. (2017). Plasma N-Terminal Probrain Natriuretic Peptide, Vascular Endothelial Growth Factor, and Cardiac Troponin I as Novel Biomarkers of Hypertensive Disease and Target Organ Damage in Cats. Journal of Veterinary Internal Medicine, 31(3), 650-660. https://doi.org/10.1111/jvim.14655