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Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity (2024)
Journal Article
Then, C., Paillas, S., Moomin, A., Misheva, M., Moir, R., Hay, S., …Kiltie, A. (2024). Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity. Microbiome, 12(1), https://doi.org/10.1186/s40168-024-01804-1

Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota... Read More about Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity.

Endothelial AHR activity prevents lung barrier disruption in viral infection (2023)
Journal Article
Major, J., Crotta, S., Finsterbusch, K., Chakravarty, P., Shah, K., Frederico, B., …Wack, A. (2023). Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature, https://doi.org/10.1038/s41586-023-06287-y

Disruption of the lung endothelial-epithelial cell barrier following respiratory virus infection causes cell and fluid accumulation in the air spaces and compromises vital gas exchange function(1). Endothelial dysfunction can exacerbate tissue damage... Read More about Endothelial AHR activity prevents lung barrier disruption in viral infection.

One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island (2023)
Journal Article
Santana-Hernandez, K., Rodriguez-Ponce, E., Medina, I., Acosta-Hernandez, B., Priestnall, S., Vega, S., …Lupiola-Gomez, P. (2023). One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island. Animals, 13(11), https://doi.org/10.3390/ani13111790

The aim of this study was to investigate the invasive species Lampropeltis californiae (California kingsnake) as a reservoir of Salmonella and its ability to spread different clones of the bacterium with zoonotic potential into the environment, as we... Read More about One Health Approach: Invasive California Kingsnake (Lampropeltis californiae) as an Important Source of Antimicrobial Drug-Resistant Salmonella Clones on Gran Canaria Island.

Pathology and causes of death in captive meerkats (<i>Suricata suricatta</i>) (2023)
Journal Article
Martí-García, B., Priestnall, S., & Suárez-Bonnet, A. (2023). Pathology and causes of death in captive meerkats (Suricata suricatta). Veterinary Quarterly, 43(1), https://doi.org/10.1080/01652176.2023.2211120

Background Meerkats (Suricata suricatta) are endemic carnivores of southern Africa and, although currently listed as 'least concern' by the International Union for Conservation of Nature (IUCN) red list, there is evidence of a significant decrease in... Read More about Pathology and causes of death in captive meerkats (<i>Suricata suricatta</i>).

Impact of exposure to urban air pollution on grey squirrel (Sciurus carolinensis) lung health (2023)
Journal Article
Torres-Blas, I., Horsler, H., Paredes, U., Perkins, M., Priestnall, S., & Brekke, P. (2023). Impact of exposure to urban air pollution on grey squirrel (Sciurus carolinensis) lung health. Environmental Pollution, 326, https://doi.org/10.1016/j.envpol.2023.121312

The increased rate of global urbanisation has recently exacerbated the significant public health problem of traffic related air pollution. Despite the known significant impact on human health, little is known about the effects of air pollution on wil... Read More about Impact of exposure to urban air pollution on grey squirrel (Sciurus carolinensis) lung health.

Additional stains and immunohistochemistry: what else can the pathologist tell us? (2022)
Journal Article
Priestnall, S., & Suarez-Bonnet, A. (2022). Additional stains and immunohistochemistry: what else can the pathologist tell us?. In Practice, 44(7), 385-393. https://doi.org/10.1002/inpr.90

Background: For the veterinary pathologist, the 'bread and butter' of our work is the tissue slide stained with haematoxylin and eosin (H&E). This has long become globally recognised as the 'standard' stain, with haematoxylin highlighting the nuclei... Read More about Additional stains and immunohistochemistry: what else can the pathologist tell us?.

Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens (2022)
Journal Article
Oros, J., Priestnall, S., & Suarez-Bonnet, A. (2022). Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens. Diseases of Aquatic Organisms, 151, 23-27. https://doi.org/10.3354/dao03686

Intensive breeding of the Siamese fighting fish Betta splendens, a species that inhabits marshlands in Thailand and other countries in south-east Asia, was traditionally focused on game fighting because the males are very territorial, but has evolved... Read More about Histopathological description of iridophoromas resembling skin nodule syndrome in Siamese fighting fish Betta splendens.

EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae (2022)
Journal Article
Soutter, F., Priestnall, S. L., Catchpole, B., & Rycroft, A. N. (2022). EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae. Journal of Comparative Pathology, https://doi.org/10.1016/j.jcpa.2022.04.004

In-vivo models of Actinobacillus pleuropneumoniae (App) infection in pigs are required for the development of vaccines and investigations of pathogenicity. Existing models cause severe respiratory disease with pulmonary oedema, dyspnoea and severe th... Read More about EXPERIMENTALLY INDUCED DISEASE An Experimental Dermal Oedema Model for Apx Toxins of Actinobacillus pleuropneumoniae.

Clinical efficacy of prebiotics and glycosaminoglycans versus placebo In dogs with food responsive enteropathy receiving a hydrolyzed diet: A pilot study (2021)
Journal Article
Glanemann, B., Seo, Y., Priestnall, S. L., Garden, O. A., Kilburn, L., Rossoni-Serao, M., … Allenspach, K. (2021). Clinical efficacy of prebiotics and glycosaminoglycans versus placebo In dogs with food responsive enteropathy receiving a hydrolyzed diet: A pilot study. PLoS ONE, https://doi.org/10.1371/journal.pone.0250681

Induction of remission is easily achieved with dietary treatment in dogs diagnosed with Food Responsive Chronic Diarrhea (FRD). Administration of prebiotics and glycosaminoglycans (GAGs) may improve epithelial cell integrity and therefore be useful a... Read More about Clinical efficacy of prebiotics and glycosaminoglycans versus placebo In dogs with food responsive enteropathy receiving a hydrolyzed diet: A pilot study.

Histopathologic Concordance Of Concurrent Duodenal And Ileal Biopsy Specimens In Dogs With Inflammatory Or Neoplastic Disease Blinded (2021)
Journal Article
Kathrani, A., Priestnall, S., & Caulfield, S. (2021). Histopathologic Concordance Of Concurrent Duodenal And Ileal Biopsy Specimens In Dogs With Inflammatory Or Neoplastic Disease Blinded. Journal of Veterinary Internal Medicine, https://doi.org/10.3390/ani11102938

Background Histopathologic discordance between intestinal locations in canine chronic enteropathy has prompted recommendations to biopsy both duodenal and ileal sites to minimize lesion oversight. Further evaluation is required for dogs with non-chr... Read More about Histopathologic Concordance Of Concurrent Duodenal And Ileal Biopsy Specimens In Dogs With Inflammatory Or Neoplastic Disease Blinded.

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection (2020)
Journal Article
Major, J., Crotta, S., Llorian, M., McCabe, T. M., Gad, H. H., Priestnall, S. L., …Wack, A. (2020). Type I and III interferons disrupt lung epithelial repair during recovery from viral infection. Science, 369(6504), 712-717. https://doi.org/10.1126/science.abc2061

Interferons (IFNs) are central to antiviral immunity. Viral recognition elicits IFN production, which in turn triggers the transcription of IFN-stimulated genes (ISGs), which engage in various antiviral functions. Type I IFNs (IFN-α and IFN-β) are wi... Read More about Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.

Peritoneal fluid accumulation in the femoral canal as a result of a post‐traumatic femoral hydrocele in a mature Warmblood stallion (2020)
Journal Article
Baldwin, C. M., Priestnall, S. L., & McMaster, M. (2020). Peritoneal fluid accumulation in the femoral canal as a result of a post‐traumatic femoral hydrocele in a mature Warmblood stallion. Equine Veterinary Education, https://doi.org/10.1111/eve.13301

The following case report documents the clinical presentation, ultrasonographic appearance, surgical management and outcome of a horse with a traumatic tear extending from the superficial and deep inguinal rings, across the aponeurosis of the externa... Read More about Peritoneal fluid accumulation in the femoral canal as a result of a post‐traumatic femoral hydrocele in a mature Warmblood stallion.

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2 (2020)
Journal Article
Arthurs, C., Suarez-Bonnet, A., Willis, C., Xie, B., Machulla, N., Mair, T. S., …Ahmed, A. (2020). Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-64014-3

Equine penile squamous cell carcinoma (EpSCC) is a relatively common cutaneous neoplasm with a poor prognosis. In this study, we aimed to determine the protein expression and colocalisation of FRA1, c-Myc, Cyclin D1, and MMP7 in normal (NT), tumour (... Read More about Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2.

Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19? (2020)
Journal Article
Priestnall, S. L. (2020). Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?. Veterinary Pathology, https://doi.org/10.1177/0300985820926485

Discovered in 2003 at the Royal Veterinary College, London, canine respiratory coronavirus (CRCoV) is a betacoronavirus of dogs and major cause of canine infectious respiratory disease complex. Generally causing mild clinical signs of persistent coug... Read More about Canine Respiratory Coronavirus: A Naturally Occurring Model of COVID-19?.

Histiocytic sarcoma in miniature schnauzers: 30 cases (2020)
Journal Article
Purzycka, K., Peters, L. M., Elliott, J., Lamb, C. R., Priestnall, S. L., Hardas, A., …Rodriguez‐Piza, I. (2020). Histiocytic sarcoma in miniature schnauzers: 30 cases. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13139

Objectives To summarise the clinical presentation and outcomes in a series of miniature schnauzers diagnosed with histiocytic sarcoma. Materials and Methods Retrospective review of medical records of miniature schnauzers diagnosed with histiocyt... Read More about Histiocytic sarcoma in miniature schnauzers: 30 cases.

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis (2020)
Journal Article
Moreira-Teixeira, L., Tabone, O., Graham, C. M., Singhania, A., Stavropoulos, E., Redford, P. S., …O’Garra, A. (2020). Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology, 21(4), 464-476. https://doi.org/10.1038/s41590-020-0610-z

Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here... Read More about Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation (2020)
Journal Article
Wu, Y., Chang, Y. M., Polton, G., Stell, A. J., Szladovits, B., Macfarlane, M., …Garden, O. A. (2020). Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00307

Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on cell of origin are generally recognized, germinal center B (GCB)-like and activated B cell (A... Read More about Gene Expression Profiling of B Cell Lymphoma in Dogs Reveals Dichotomous Metabolic Signatures Distinguished by Oxidative Phosphorylation.

Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study (2020)
Journal Article
Jones, A. L., Suárez-Bonnet, A., Mitchell, J. A., Ramirez, G. A., Stidworthy, M. F., & Priestnall, S. L. (2020). Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study. Journal of Comparative Pathology, 175, 13-23. https://doi.org/10.1016/j.jcpa.2019.11.007

In this retrospective study, we describe the histopathological findings in seven papillomas and 45 squamous cell carcinomas (SCCs) from psittacine birds, raptors and domestic fowl. The age of affected birds ranged from 3 to 40 years, with median age... Read More about Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study.