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Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro (2024)
Journal Article
Curel, C. J. M., Nobeli, I., & Thornton, C. (2024). Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro. Cells, 13(7), 631. https://doi.org/10.3390/cells13070631

Neonatal hypoxia-ischemia (HI) affects 2-3 per 1000 live births in developed countries and up to 26 per 1000 live births in developing countries. It is estimated that of the 750,000 infants experiencing a hypoxic-ischemic event during birth per year,... Read More about Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference (2022)
Journal Article
Beiser, T., Lisniansky, E., Weitz, M., Bingor, A., Grad, E., Rosenblum, K., Thornton, C., & Yaka, R. (2022). A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference. Translational Psychiatry, 12, Article 460. https://doi.org/10.1038/s41398-022-02232-1

Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate, eEF2. However, the involvement of the eEF2 pathway in cocaine-induced neuroadaptations and cocaine-ind... Read More about A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference.

Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations (2022)
Journal Article
Kuroda, T., Minamijima, Y., Mita, H., Tamura, N., Fukuda, K., Kuwano, A., Toutain, P., & Sato, F. (2022). Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13099

A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine
the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration
of CEZ in horses. Seven horses received a single IM or intravenous (IV) administ... Read More about Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.

Bats actively modulate membrane compliance to control camber and reduce drag (2022)
Journal Article
Cheney, J., Rehm, J., Swartz, S., & Breuer, K. (in press). Bats actively modulate membrane compliance to control camber and reduce drag. Journal of Experimental Biology, https://doi.org/10.1242/jeb.243974

Bat wing skin is exceptionally compliant and cambers significantly during flight. Plagiopatagiales proprii, arrays of small muscles embedded in the armwing membrane, are activated during flight and are hypothesized to modulate membrane tension. We ex... Read More about Bats actively modulate membrane compliance to control camber and reduce drag.

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury? (2022)
Journal Article
Jones, A., & Thornton, C. (2022). Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?. Bioscience Reports, https://doi.org/10.1042/BSR20211696

The impact of birth asphyxia and its sequelae, hypoxic-ischaemic brain injury, is long lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not universally successful an... Read More about Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?.

Virtual manipulation of tail postures of a gliding barn owl (Tyto alba) demonstrates drag minimisation when gliding (2022)
Journal Article
Song, J., Cheney, J., Bomphrey, R., & Usherwood, J. (2023). Virtual manipulation of tail postures of a gliding barn owl (Tyto alba) demonstrates drag minimisation when gliding. Journal of the Royal Society, Interface, https://doi.org/10.1098/rsif.2021.0710

Aerodynamic functions of the avian tail have been studied previously using observations of bird flight, physical models in wind tunnels, theoretical modelling, and flow visualization. However, none of these approaches has provided rigorous, quantitat... Read More about Virtual manipulation of tail postures of a gliding barn owl (Tyto alba) demonstrates drag minimisation when gliding.

S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability (2021)
Journal Article
Warboys, C. M., & Weinberg, P. D. (2021). S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability. Tissue Barriers, https://doi.org/10.1080/21688370.2021.1959243

Atherosclerosis is characterised by focal accumulations of lipid within the arterial wall, thought to arise from effects of haemodynamic wall shear stress (WSS) on endothelial permeability. Identifying pathways that mediate effects of shear on permea... Read More about S1P in the development of atherosclerosis: roles of haemodynamic wall shear stress and endothelial permeability.

Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor (2021)
Journal Article
Pang, K. T., Ghim, M., Liu, C., Tay, H. M., Fhu, C. W., Chia, R. N., Qiu, B., Sarathchandra, P., Chester, A. H., Yacoub, M. H., Wilkinson, F. L., Weston, R., Warboys, C. M., Hou, H. W., Weinberg, P. D., & Wang, X. (2021). Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers in Cell and Developmental Biology, 9, https://doi.org/10.3389/fcell.2021.706143

Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endoth... Read More about Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.

The zebrafish cardiac endothelial cell – roles in development and regeneration (2021)
Journal Article
Pellet-Many, C., Lowe, V., & Wisniewski, L. (2021). The zebrafish cardiac endothelial cell – roles in development and regeneration. Journal of Cardiovascular Development and Disease,

In zebrafish, the spatiotemporal development of the vascular system is well described due to its stereotypical nature. However, the cellular and molecular mechanisms orchestrating post embryonic vascular development, the maintenance of vascular homeo... Read More about The zebrafish cardiac endothelial cell – roles in development and regeneration.

The role of mitochondria in cocaine addiction (2021)
Journal Article
Thornton, C., Grad, E., & Yaka, R. (in press). The role of mitochondria in cocaine addiction. Biochemical Journal,

The incidence of cocaine abuse is increasing especially in the UK where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxida... Read More about The role of mitochondria in cocaine addiction.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Rigon, M., Faccenda, D., Alvarez, M. S., Singh, A., Mainenti, M., Hussey, L. K., Bentham, R., Szabadkai, G., Zappulli, V., Dhoot, G., Romano, L. E., Dong, X., Coppens, I., Hamacher-Brady, A., Chapple, J. P., Abeti, R., …Campanella, M. (in press). Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response. Science Advances, https://doi.org/10.1101/445411

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as Mitochondrial Retrograde Response (MRR) and is induced by mitochondrial dysfunctions. MRR results in the nuclear stabilization of pro-s... Read More about Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response.

Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Faccenda, D., Alvarex, M. S., Mainenti, M., Kuhlman Hussy, L., Bentham, R., Szabadkai, G., Zappulli, V., Dhoot, G., Fleck, R. A., Vizcay-Barrena, G., Smith, K., & Campanella, M. (2020). Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response. Science Advances, https://doi.org/10.1101/445411

Cholesterol metabolism is pivotal to cellular homeostasis, hormones production, and membranes composition. Its dysregulation associates with malignant reprogramming and therapy resistance. Cholesterol is trafficked into the mitochondria for steroidog... Read More about Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response.

Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds (2020)
Journal Article
Usherwood, J. R., & Granatosky, M. C. (2020). Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds. Proceedings of the Royal Society B: Biological Sciences, 287(1940), 20201517. https://doi.org/10.1098/rspb.2020.1517

Quadrupedal animal locomotion is energetically costly. We explore two forms of mechanical work that may be relevant in imposing these physiological demands. Limb work, due to the forces and velocities between the stance foot and the centre of mass, c... Read More about Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds.

The new age of renal biomarkers: does SDMA solve all of our problems? (2020)
Journal Article
Sargent, H. J., Elliott, J., & Jepson, R. E. (2020). The new age of renal biomarkers: does SDMA solve all of our problems?. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13236

Within clinical small animal practice, diagnosis of both chronic kidney disease and acute kidney injury is common. To assess renal function, measurement of glomerular filtration rate is considered the gold standard. Currently, routine tests of kidney... Read More about The new age of renal biomarkers: does SDMA solve all of our problems?.

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis (2020)
Journal Article
Moreira-Teixeira, L., Stimpson, P. J., Stavropoulos, E., Hadebe, S., Chakravarty, P., Ioannou, M., Aramburu, I. V., Herbert, E., Priestnall, S. L., Suarez-Bonnet, A., Sousa, J., Fonseca, K. L., Wang, Q., Vashakidze, S., Rodríguez-Martínez, P., Vilaplana, C., Saraiva, M., Papayannopoulos, V., & O’Garra, A. (2020). Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis. Nature Communications, 11(1), 5566. https://doi.org/10.1038/s41467-020-19412-6

Abstract: Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were sh... Read More about Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.

Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits (2020)
Journal Article
Sweet‐Jones, J., Yurchenko, A. A., Igoshin, A. V., Yudin, N. S., Swain, M. T., & Larkin, D. M. (2021). Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits. Animal Genetics, https://doi.org/10.1111/age.13015

There and back again - a zebra's tale (2020)
Journal Article
Bartlam-Brooks, H., Wilshin, S., Hubel, T., Hailes, S., Bennitt, E., & Wilson, A. M. (2020). There and back again - a zebra's tale. Journal of Experimental Biology, jeb.232140. https://doi.org/10.1242/jeb.232140

Animals need to navigate between resources such as water, food and shelter and how they achieve this is likely to vary with species. Here, using high accuracy GPS data, we study repeated journeys made by wild zebra (Equus quagga) through a naturally... Read More about There and back again - a zebra's tale.