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Ontogenetic scaling patterns and functional anatomy of the pelvic limb musculature in emus (Dromaius novaehollandiae) (2014)
Journal Article
Lamas, L., Main, R. P., & Hutchinson, J. R. (2014). Ontogenetic scaling patterns and functional anatomy of the pelvic limb musculature in emus (Dromaius novaehollandiae). https://doi.org/10.7717/peerj.716

Emus (Dromaius novaehollandiae) are exclusively terrestrial, bipedal and cursorial ratites with some similar biomechanical characteristics to humans. Their growth rates are impressive, as their body mass increases eighty-fold from hatching to adultho... Read More about Ontogenetic scaling patterns and functional anatomy of the pelvic limb musculature in emus (Dromaius novaehollandiae).

Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies (2014)
Journal Article
Anfinsen, K. P., Berghoff, N., Priestnall, S. L., Suchodolski, J. S., Steiner, J. M., & Allenspach, K. (2014). Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies. Acta Veterinaria Scandinavica, 56(90), https://doi.org/10.1186/s13028-014-0090-y

This study sought to correlate faecal and urinary N-methylhistamine (NMH) concentrations with resting versus degranulated duodenal mast cell numbers in dogs with chronic enteropathies (CE), and investigate correlations between intestinal mast cell ac... Read More about Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies.

Comparative genomics reveals insights into avian genome evolution and adaptation (2014)
Journal Article
Zhang, G., Li, C., Li, Q., Li, B., Larkin, D. M., & Lee, C. (2014). Comparative genomics reveals insights into avian genome evolution and adaptation. Science, 346(6215), 1311-1320. https://doi.org/10.1126/science.1251385

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is prin... Read More about Comparative genomics reveals insights into avian genome evolution and adaptation.

Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor (2014)
Journal Article
Romanov, M. N., Farré, M., Lithgow, P. E., Fowler, K. E., Skinner, B. M., O'Connor, R., …Griffin, D. K. (2014). Reconstruction of gross avian genome structure, organization and evolution suggests that the chicken lineage most closely resembles the dinosaur avian ancestor. BMC Genomics, 15, https://doi.org/10.1186/1471-2164-15-1060

Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response (2014)
Journal Article
Patterson, N. J., Günther, J., Gibson, A. J., Offord, V., Coffey, T. J., Splitter, G., …Werling, D. (2014). Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Frontiers in Microbiology, 5(662), https://doi.org/10.3389/fmicb.2014.00662

Staphylococcus aureus, sequence type (ST) 398, is an emerging pathogen and the leading cause of livestock-associated methicillin-resistant S. aureus infections in Europe and North America. This strain is characterized by high promiscuity in terms of... Read More about Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.

Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake (2014)
Journal Article
Adams, J. P., Holder, A. L., & Catchpole, B. (2014). Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake. https://doi.org/10.1016/j.tvjl.2014.09.027

Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in... Read More about Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake.

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control (2014)
Journal Article
Gatliff, J., East, D. A., Crosby, J., Abeti, R., Harvey, R., Craigen, W., …Campanella, M. (2014). TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy, 10(12), 2279-96. https://doi.org/10.4161/15548627.2014.991665

The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essenti... Read More about TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.

Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1) (2014)
Journal Article
Freidl, G. S., Meijer, A., De Bruin, E., De Nardi, M., Munoz, O., Capua, I., …FLURISK Consortium. (2014). Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1). Eurosurveillance, 19(18),

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the... Read More about Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1).

Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging (2014)
Journal Article
Boyde, A., McCorkell, F. A., Taylor, G. K., Bomphrey, R. J., & Doube, M. (2014). Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging. Microscopy Research and Technique, 77(12), 1044-1051. https://doi.org/10.1002/jemt.22435

Iodine imparts strong contrast to objects imaged with electrons and X‐rays due to its high atomic number (53), and is widely used in liquid form as a microscopic stain and clinical contrast agent. We have developed a simple technique which exploits e... Read More about Iodine vapor staining for atomic number contrast in backscattered electron and X-ray imaging.

Application of integrated production and economic models to estimate the impact of Schmallenberg virus for various sheep production types in the UK and France (2014)
Journal Article
Alarcon, P., Haesler, B., Raboisson, D., Waret-Szkuta, A., Corbiere, F., & Rushton, J. (2014). Application of integrated production and economic models to estimate the impact of Schmallenberg virus for various sheep production types in the UK and France. Veterinary Record, 1(1), e000036-e000036. https://doi.org/10.1136/vetreco-2014-000036

The present study aimed to estimate and compare the economic impact of Schmallenberg virus (SBV) in different sheep production holdings using partial budget and gross margin analyses in combination with production models. The sheep production types... Read More about Application of integrated production and economic models to estimate the impact of Schmallenberg virus for various sheep production types in the UK and France.

PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy (2014)
Journal Article
East, D. A., Fagiani, F., Crosby, J., Georgakopoulos, N. D., Bertrand, H., Schaap, M., …Campanella, M. (2014). PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy. https://doi.org/10.1016/j.chembiol.2014.09.019

Mitophagy is central to mitochondrial and cellular homeostasis and operates via the PINK1/Parkin pathway targeting mitochondria devoid of membrane potential (ΔΨm) to autophagosomes. Although mitophagy is recognized as a fundamental cellular process,... Read More about PMI: A Delta Psi(m) Independent Pharmacological Regulator of Mitophagy.

The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation (2014)
Journal Article
Bossé, J. T., Soares-Bazzolli, D. M., Li, Y., Wren, B. W., Tucker, A. W., Maskell, D. J., …BRaDP1T Consortium, . (2014). The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation. PLoS ONE, 9(11), https://doi.org/10.1371/journal.pone.0111252

We have developed a simple method of generating scarless, unmarked mutations in Actinobacillus pleuropneumoniae by exploiting the ability of this bacterium to undergo natural transformation, and with no need to introduce plasmids encoding recombinase... Read More about The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation.

Increasing antimicrobial resistance in clinical isolates of Staphylococcus intermedius group bacteria and emergence of MRSP in the UK (2014)
Journal Article
Beever, L. J., Bond, R., Graham, P. A., Jackson, B. F., Lloyd, D. H., & Loeffler, A. (2014). Increasing antimicrobial resistance in clinical isolates of Staphylococcus intermedius group bacteria and emergence of MRSP in the UK. Veterinary Record, 176(7), 172+. https://doi.org/10.1136/vr.102651

Frequencies of antimicrobial resistance were determined amongst 14,555 clinical Staphylococcus intermedius group (SIG) isolates from UK dogs and cats to estimate resistance trends and quantify the occurrence of meticillin-resistant Staphylococcus pse... Read More about Increasing antimicrobial resistance in clinical isolates of Staphylococcus intermedius group bacteria and emergence of MRSP in the UK.

Benefits of a ball and chain: simple environmental enrichments improve welfare and reproductive success in farmed American mink (Neovison vison) (2014)
Journal Article
Meagher, R. K., Dallaire, J. A., Campbell, D. L. M., Ross, M., Moller, S. H., Hansen, S. W., …Mason, G. (2014). Benefits of a ball and chain: simple environmental enrichments improve welfare and reproductive success in farmed American mink (Neovison vison). PLoS ONE, 9(11), e110589. https://doi.org/10.1371/journal.pone.0110589

Can simple enrichments enhance caged mink welfare? Pilot data from 756 sub-adults spanning three colour-types (strains) identified potentially practical enrichments, and suggested beneficial effects on temperament and fur-chewing. Our main experiment... Read More about Benefits of a ball and chain: simple environmental enrichments improve welfare and reproductive success in farmed American mink (Neovison vison).

Feline hyperthyroidism reported in primary-care veterinary practices in England: prevalence, associated factors and spatial distribution (2014)
Journal Article
Stephens, M. J., O'Neill, D. G., Church, D. B., McGreevy, P. D., Thomson, P. C., & Brodbelt, D. C. (2014). Feline hyperthyroidism reported in primary-care veterinary practices in England: prevalence, associated factors and spatial distribution. Veterinary Record, 175(18), https://doi.org/10.1136/vr.102431

Feline hyperthyroidism is a commonly diagnosed endocrinopathy that can have a substantial deleterious impact on the welfare of affected cats. This study aimed to estimate the prevalence, associated factors and geographical distribution for feline hyp... Read More about Feline hyperthyroidism reported in primary-care veterinary practices in England: prevalence, associated factors and spatial distribution.

Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential (2014)
Journal Article
Falkingham, P. L., Hage, J., & Baeker, M. (2014). Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential. Royal Society Open Science, 1(3), 140225. https://doi.org/10.1098/rsos.140225

In ichnology, the Goldilocks effect describes a scenario in which a substrate must be ‘just right’ in order for tracks to form—too soft, the animal will be unable to traverse the area, and too firm, the substrate will not deform. Any given substrate... Read More about Mitigating the Goldilocks effect: the effects of different substrate models on track formation potential.