Skip to main content

Research Repository

Advanced Search

Outputs (452)

Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella (2017)
Journal Article
Marugan-Hernandez, V., Fiddy, R., Nurse-Francis, J., Smith, O., Pritchard, L., & Tomley, F. M. (2017). Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella. https://doi.org/10.1186/s13071-017-2454-4

In this study, we evaluated the binding capacity of Type I MAR domains from novel E. tenella MCPs. Variants of the previously described HxT motif were analysed showing that HxT and VxT variants bind, whereas HxS and YxE variants did not. One of these... Read More about Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella.

One Health Economics to confront disease threats (2017)
Journal Article
Machalaba, C., Smith, K. M., Awada, L., Berry, K., Berthe, F., Bouley, T. A., Bruce, M., Cortiñas Abrahantes, J., El Turabi, A., Feferholtz, Y., Flynn, L., Fournié, G., Andre, A., Grace, D., Jonas, O., Kimani, T., Le Gall, F., Miranda, J. J., Peyre, M., Pinto, J., …Karesh, W. B. (2017). One Health Economics to confront disease threats. Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(6), 235-237

Global economic impacts of epidemics suggest high return on investment in prevention and One Health capacity. However, such investments remain limited, contributing to persistent endemic diseases and vulnerability to emerging ones. An interdisciplina... Read More about One Health Economics to confront disease threats.

Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock (2017)
Journal Article
Gower, C. M., Vince, L., & Webster, J. P. (2017). Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock. Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(6), 244-247

A One Health economic perspective allows informed decisions to be made regarding control priorities and/or implementation strategies for infectious diseases. Schistosomiasis is a major and highly resilient disease of both humans and livestock. The zo... Read More about Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock.

Practices of traditional beef farmers in their production and marketing of cattle in Zambia (2017)
Journal Article
Mumba, C., Haesler, B., Muma, J. B., Munyeme, M., Sitali, D. C., Skjerve, E., & Rich, K. M. (2017). Practices of traditional beef farmers in their production and marketing of cattle in Zambia. Tropical Animal Health and Production, 50(1), 49-62. https://doi.org/10.1007/s11250-017-1399-0

Understanding the practices of traditional cattle farmers in developing countries is an important factor in the development of appropriate, pro-poor disease control policies, and in formulating regional-specific production incentives that can improve... Read More about Practices of traditional beef farmers in their production and marketing of cattle in Zambia.

Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology (2017)
Journal Article
Macdonald, S. E., Nolan, M. J., Harman, K., Boulton, K., Hume, D. A., Tomley, F. M., Stabler, R. A., & Blake, D. P. (2017). Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12(9), e0184890. https://doi.org/10.1371/journal.pone.0184890

Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and prod... Read More about Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology.

Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition (2017)
Journal Article
Jenkins, T. P., Rathnayaka, Y., Perera, P. K., Peachey, L. E., Nolan, M. J., Krause, L., Rajakaruna, R. S., & Cantacessi, C. (2017). Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition. PLoS ONE, 12(9), e0184719. https://doi.org/10.1371/journal.pone.0184719

Investigations of the impact that patent infections by soil-transmitted gastrointestinal nematode parasites exert on the composition of the host gut commensal flora are attracting growing interest by the scientific community. However, information col... Read More about Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition.

Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis (2017)
Journal Article
Kamaruzzaman, N. F., Chong, S. Q. Y., Edmondson-Brown, K. M., Ntow-Boahene, W., Bardiau, M., & Good, L. (2017). Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis. Frontiers in Microbiology, 11(8), 1518. https://doi.org/10.3389/fmicb.2017.01518

Staphylococcus aureus infection is a common cause of mastitis, reducing milk yield, affecting animal welfare and causing huge economic losses within the dairy industry. In addition to the problem of acquired drug resistance, bacterial invasion into u... Read More about Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis.

Cultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers (2017)
Journal Article
Delabouglise, A., Antoine-Moussiaux, N., Tatong, D., Chumkaeo, A., Binot, A., Fournié, G., Pilot, E., Phimpraphi, W., Kasemsuwan, S., Paul, M. C., Duboz, R., Salem, G., & Peyre, M. (2017). Cultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers. Transboundary and Emerging Diseases, 64(4), 1294-1305. https://doi.org/10.1111/tbed.12506

Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Evaluating the acceptability of passive surveillance and its economic, social and cultura... Read More about Cultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers.

Drivers for Rift Valley fever emergence in Mayotte: A Bayesian modelling approach (2017)
Journal Article
Métras, R., Fournié, G., Dommergues, L., Camacho, A., Cavalerie, L., Mérot, P., Keeling, M. J., Cêtre-Sossah, C., Cardinale, E., & Edmunds, W. J. (2017). Drivers for Rift Valley fever emergence in Mayotte: A Bayesian modelling approach. PLoS Neglected Tropical Diseases, 11(7), e0005767. https://doi.org/10.1371/journal.pntd.0005767

Rift Valley fever (RVF) is a major zoonotic and arboviral hemorrhagic fever. The conditions leading to RVF epidemics are still unclear, and the relative role of climatic and anthropogenic factors may vary between ecosystems. Here, we estimate the mos... Read More about Drivers for Rift Valley fever emergence in Mayotte: A Bayesian modelling approach.

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration (2017)
Journal Article
Burkitt, M. D., Williams, J. M., Townsend, T., Hough, R., & Pritchard, D. M. (2017). Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration. https://doi.org/10.1038/cddis.2017.332

Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of... Read More about Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.

Economic factors influencing zoonotic disease dynamics: demand for poultry meat and seasonal transmission of avian influenza in Vietnam (2017)
Journal Article
Delabouglise, A., Choisy, M., Phan, T. D., Antoine-Moussiaux, N., Peyre, M., Vu, T. D., Pfeiffer, D. U., & Fournié, G. (2017). Economic factors influencing zoonotic disease dynamics: demand for poultry meat and seasonal transmission of avian influenza in Vietnam. Scientific Reports, 7, 5905. https://doi.org/10.1038/s41598-017-06244-6

While climate is often presented as a key factor influencing the seasonality of diseases, the importance of anthropogenic factors is less commonly evaluated. Using a combination of methods-wavelet analysis, economic analysis, statistical and disease... Read More about Economic factors influencing zoonotic disease dynamics: demand for poultry meat and seasonal transmission of avian influenza in Vietnam.

The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness (2017)
Journal Article
Walker, M., Pion, S. D. S., Fang, H., Gardon, J., Kamgno, J., Basáñez, M.-G., & Boussinesq, M. (2017). The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness. Clinical Infectious Diseases, 65(12), 2026-2034. https://doi.org/10.1093/cid/cix616

Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca vol... Read More about The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness.

Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multicountry study (2017)
Journal Article
Sauter-Louis, C., Jones, B. A., Henning, J., Stoll, A., Nielen, M., Van Schaik, G., Smolenaars, A., Schouten, M., den Uijl, I., Fourichon, C., Guatteo, R., Madouasse, A., Nusinovici, S., Deprez, P., De Vliegher, S., Laureynes, J., Booth, R., Cardwell, J. M., & Pfeiffer, D. U. (2017). Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multicountry study. PLoS ONE, 12(7), https://doi.org/10.1371/journal.pone.0179878

Since 2007, mortality associated with a previously unreported haemorrhagic disease has been observed in young calves in several European countries. The syndrome, which has been named ‘bovine neonatal pancytopenia’ (BNP), is characterised by thrombocy... Read More about Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multicountry study.

Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle (2017)
Journal Article
Marugan-Hernandez, V., Long, E., Blake, D. P., Crouch, C., & Tomley, F. M. (2017). Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle. https://doi.org/10.1038/s41598-017-04049-1

Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp. as recombinant vectors to express ad... Read More about Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle.