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HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth (2015)
Journal Article
Blondelle, J., Ohno, Y., Gache, V., Guyot, S., Storck, S., Blanchard-Gutton, N., …Pilot-Storck, F. (2015). HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Journal of Molecular Cell Biology, 7(5), 429-440. https://doi.org/10.1093/jmcb/mjv049

The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate the role of HACD1/PTPLA, which is involved in the elongation... Read More about HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth.

Understanding hind limb lameness signs in horses using simple rigid body mechanics (2015)
Journal Article
Starke, S. D., May, S. A., & Pfau, T. (2015). Understanding hind limb lameness signs in horses using simple rigid body mechanics. Journal of Biomechanics, 48(12), 3323-3331. https://doi.org/10.1016/j.jbiomech.2015.06.019

Hind limb lameness detection in horses relies on the identification of movement asymmetry which can be based on multiple pelvic landmarks. This study explains the poorly understood relationship between hind limb lameness pointers, related to the tube... Read More about Understanding hind limb lameness signs in horses using simple rigid body mechanics.

The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry (2015)
Journal Article
Henningsson, P., Michaelis, D., Nakata, T., Schanz, D., Geisler, R., Schroeder, A., & Bomphrey, R. J. (2015). The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry. https://doi.org/10.1098/rsif.2015.0119

Particle image velocimetry has been the preferred experimental technique with which to study the aerodynamics of animal flight for over a decade. In that time, hardware has become more accessible and the software has progressed from the acquisition o... Read More about The complex aerodynamic footprint of desert locusts revealed by large-volume tomographic particle image velocimetry.

Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis (2015)
Journal Article
Akbareian, S. E., Pitsillides, A. A., Macharia, R. G., & McGonnell, I. M. (2015). Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis. Journal of Anatomy, 226(6), 560-574. https://doi.org/10.1111/joa.12304

Cranial foramina are holes within the skull, formed during development, allowing entry and exit of blood vessels and nerves. Once formed they must remain open, due to the vital structures they contain, i.e. optic nerves, jugular vein, carotid artery,... Read More about Occipital foramina development involves localised regulation of mesenchyme proliferation and is independent of apoptosis.

Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis (2015)
Journal Article
Zolfaghari, P. S., Carré, J. E., Parker, N., Curtin, N. A., Duchen, M. R., & Singer, M. (2015). Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis. https://doi.org/10.1152/ajpendo.00562.2014

Muscle dysfunction is a common feature of severe sepsis and multi-organ failure. Recent evidence implicates bioenergetic dysfunction and oxidative damage as important underlying pathophysiological mechanisms. Increased abundance of uncoupling protein... Read More about Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis.

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength (2015)
Journal Article
Lim, S., Marenzana, M., Hopkinson, M., List, E., Kopchick, J., Pereira, M., …Chenu, C. (2015). Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength. Endocrinology, 156(4), 1362-1371. https://doi.org/10.1210/en.2014-1572

Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic... Read More about Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.

DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL (2015)
Journal Article
Charles, J. P., Cappellari, O., Spence, A., Wells, D. J., & Hutchinson, J. R. (2015). DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL. FASEB Journal, 29,

Stability during locomotion arises from many complex interactions which are not yet fully understood. Studies into how sensory feedback from muscle spindles contributes to this have used neuromechanical simulations, however their accuracy is limited... Read More about DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL.

FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS) (2015)
Journal Article
Chadwick, K. P., Allen, V. R., & Hutchinson, J. R. (2015). FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS). FASEB Journal, 29(1),

Mechanical stimulation is accepted to play some role in the development of sesamoid bones, however with great variability in occurrence, it is not yet clear how significant this role is and what specific loading environment fosters or hinders growth.... Read More about FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS).

Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications (2015)
Journal Article
Bolton, S. N., Whitehead, M. P., Dudhia, J., Baldwin, T. C., & Sutton, R. (2015). Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications. Journal of Forensic Sciences, 60(4), 1061-67. https://doi.org/10.1111/1556-4029.12764

This study investigated the postmortem molecular changes that articular cartilage undergoes following burial. Fresh pig trotters were interred in 30‐cm‐deep graves at two distinct locations exhibiting dissimilar soil environments for up to 42 days. E... Read More about Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications.

Symmorphosis through Dietary Regulation: A Combinatorial Role for Proteolysis, Autophagy and Protein Synthesis in Normalising Muscle Metabolism and Function of Hypertrophic Mice after Acute Starvation (2015)
Journal Article
Collins-Hooper, H., Sartori, R., Giallourou, N., Matsakas, A., Mitchell, R., Mararenkova, H., …Patel, K. (2015). Symmorphosis through Dietary Regulation: A Combinatorial Role for Proteolysis, Autophagy and Protein Synthesis in Normalising Muscle Metabolism and Function of Hypertrophic Mice after Acute Starvation. PLoS ONE, 10(3), https://doi.org/10.1371/journal.pone.0120524

Animals are imbued with adaptive mechanisms spanning from the tissue/organ to the cellular scale which insure that processes of homeostasis are preserved in the landscape of size change. However we and others have postulated that the degree of adapta... Read More about Symmorphosis through Dietary Regulation: A Combinatorial Role for Proteolysis, Autophagy and Protein Synthesis in Normalising Muscle Metabolism and Function of Hypertrophic Mice after Acute Starvation.

Local origins impart conserved bone type-related differences in human osteoblast behaviour (2015)
Journal Article
Shah, M., Gburcik, V., Reilly, P., Sankey, R. A., Emery, R. J., Clarkin, C. E., & Pitsillides, A. A. (2015). Local origins impart conserved bone type-related differences in human osteoblast behaviour. https://doi.org/10.22203/eCM.v029a12

Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; a... Read More about Local origins impart conserved bone type-related differences in human osteoblast behaviour.

Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis (2015)
Journal Article
Voelkl, B., Portugal, S. J., Unsoeld, M., Usherwood, J. R., Wilson, A. M., & Fritz, J. (2015). Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis. https://doi.org/10.1073/pnas.1413589112

One conspicuous feature of several larger bird species is their annual migration in V-shaped or echelon formation. When birds are flying in these formations, energy savings can be achieved by using the aerodynamic up-wash produced by the preceding bi... Read More about Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis.

Is a standalone inertial measurement unit accurate and precise enough for quantification of movement symmetry in the horse? (2015)
Journal Article
Brighton, C., Olsen, E., & Pfau, T. (2015). Is a standalone inertial measurement unit accurate and precise enough for quantification of movement symmetry in the horse?. Computer Methods in Biomechanics and Biomedical Engineering, 18(5), 527-532. https://doi.org/10.1080/10255842.2013.819857

Standalone ‘low-cost’ inertial measurement units (IMUs) could facilitate large-scale studies into establishing minimal important differences (MID) for orthopaedic deficits (lameness) in horses. We investigated accuracy and limits of agreement (LoA) a... Read More about Is a standalone inertial measurement unit accurate and precise enough for quantification of movement symmetry in the horse?.

Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds (2015)
Journal Article
Regnault, S., Pitsillides, A. A., & Hutchinson, J. R. (2015). Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds. https://doi.org/10.7717/peerj.711

The patella (kneecap) exhibits multiple evolutionary origins in birds, mammals, and lizards, and is thought to increase the mechanical advantage of the knee extensor muscles. Despite appreciable interest in the specialized anatomy and locomotion of p... Read More about Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds.