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Welcome to RVC Repository

RVC Research Online is a repository of the research outputs produced by staff from the Royal Veterinary College (RVC). The aims of the repository are (i) to provide an institutional archive of RVC's research outputs, (ii) to provide access to these outputs and support open science, and (iii) to increase the reach and impact of RVC's research.

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Latest Additions

Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis) (2024)
Journal Article
Martí-García, B., Priestnall, S., Torres, Y., & Suárez-Bonnet, A. (2024). Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis). Laboratory Animals, https://doi.org/10.1177/00236772241273060

Three seven-year-old African clawed frogs (Xenopus laevis) from an animal research facility showed weight loss, coelomic distention and an abnormal swimming gait were euthanised on welfare grounds. A complete necropsy of each animal showed a focal, f... Read More about Spontaneous hepatocellular and gastric tumours in African clawed frogs (Xenopus laevis).

Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics (2024)
Journal Article
Kuroda, T., Minamijima, Y., Kinman, C., Takahashi, Y., Ebisuda, Y., Inoue, K., Ishikawa, H., Mita, H., Tamura, N., Nukada, T., Toutain, P., & Ohta, M. (2024). Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics. Frontiers in Veterinary Science, 11, https://doi.org/10.3389/fvets.2024.1454342

Introduction Quinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects. The purpose of this study... Read More about Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics.

Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors (2024)
Journal Article
Allan, F., Watson, A., & Syme, H. (2024). Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.17212

Background: Functionality of human adrenal tumors is inferred by CYP11B1 (cortisol synthase) expression, CYP11B2 (aldosterone synthase) expression, or both. Hypothesis/Objectives: Nonfunctional canine adrenal tumors have low expression of steroidogen... Read More about Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors.

Leukemia cutis as a prominent clinical sign in a dog with acute myeloid leukemia (2024)
Journal Article
Rogato, F., Szladovits, B., Martineau, H., Yale, A. D., Mitchell, J. L., Holmes, E. J., Gardner, R. H., & Guillén, A. (in press). Leukemia cutis as a prominent clinical sign in a dog with acute myeloid leukemia. Veterinary Clinical Pathology, https://doi.org/10.1111/vcp.13382

An eight-year-old male neutered crossbreed dog presented with erosive and ulcerative cutaneous lesions in the inguinal regions, the medial aspect of both thighs, and the stifles. Hematologic assessment revealed nonregenerative anemia, thrombocytopeni... Read More about Leukemia cutis as a prominent clinical sign in a dog with acute myeloid leukemia.