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Welcome to RVC Repository

RVC Research Online compiles the research outputs of academics and clinical staff from the Royal Veterinary College.
The aim of the repository is to: provide a long-term home for research outputs from the College; supply access to full-text versions of these outputs; support the practice of open science across the entire range of the College's research activity; and, increase the impact and reach of the College's research.



Latest Additions

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference (2022)
Journal Article
Beiser, T., Lisniansky, E., Weitz, M., Bingor, A., Grad, E., Rosenblum, K., …Yaka, R. (2022). A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference. Translational Psychiatry, 12, Article 460. https://doi.org/10.1038/s41398-022-02232-1

Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate, eEF2. However, the involvement of the eEF2 pathway in cocaine-induced neuroadaptations and cocaine-ind... Read More about A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference.

Nutritional Management of Acute Pancreatitis (2022)
Journal Article
Chan, D. L. (2022). Nutritional Management of Acute Pancreatitis. Advances in Small Animal Medicine and Surgery, 3(1), 221-227. https://doi.org/10.1016/j.yasa.2022.05.006

KEY POINTS - Nutritional support is considered a key part of management of patients with acute pancreatitis. . - Feeding should be attempted in all patients if cardiovascularly stable, and parenteral nutrition should not be considered unless e... Read More about Nutritional Management of Acute Pancreatitis.

Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations (2022)
Journal Article
Kuroda, T., Minamijima, Y., Mita, H., Tamura, N., Fukuda, K., Kuwano, A., …Sato, F. (2022). Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13099

A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration of CEZ in horses. Seven horses received a single IM or intravenous (IV) administ... Read More about Rational determination of cefazolin dosage regimen in horses based on pharmacokinetics/pharmacodynamics principles and Monte Carlo simulations.

What Did We Learn About Fracture Pain from Animal Models? (2022)
Journal Article
Radulescu, A., White, F. A., & Chenu, C. (in press). What Did We Learn About Fracture Pain from Animal Models?. Journal of Pain Research, Volume 15, 2845-2856. https://doi.org/10.2147/jpr.s361826

Progress in bone fracture repair research has been made possible due to the development of reproducible models of fracture in rodents with more clinically relevant fracture fixation, where there is considerably better assessment of the factors that a... Read More about What Did We Learn About Fracture Pain from Animal Models?.