Outputs (19)

Calculation of standard bodyweights for dogs, cats, rabbits, and guinea pigs (2025)
Journal Article
O'Neill, D., Becker, S. D., Frosini, S.-M., Stapleton, L. E., Hughes, D. M., & Brodbelt, D. C. (2025). Calculation of standard bodyweights for dogs, cats, rabbits, and guinea pigs. PLoS ONE, 20(2), e0318734. https://doi.org/10.1371/journal.pone.0318734

Standard bodyweights are an essential component of calculations that summarise many
population-level measures in companion animals, including the defined daily doses for
veterinary species (DDDVet) reporting antimicrobial usage. Standard species bo... Read More about Calculation of standard bodyweights for dogs, cats, rabbits, and guinea pigs.

Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis (2024)
Journal Article
Gap-Gaupool, B., Glenn, S. M., Milburn, E., Turapov, O., Crosatti, M., Hincks, J., Stewart, B., Bacon, J., Kendall, S. L., Voskuil, M. I., Riabova, O., Monakhova, N., Green, J., Waddell, S. J., Makarov, V. A., & Mukamolova, G. V. (in press). Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis. Communications Biology, 7(1), https://doi.org/10.1038/s42003-024-06912-0

Detecting Closer to Care: Combining Phage and LAMP to Detect Tuberculosis, Bovine TB and Johne’s Disease (2024)
Journal Article
Shield, C. G., Bartlett, A. E. M., Haldar, P., & Swift, B. M. C. (in press). Detecting Closer to Care: Combining Phage and LAMP to Detect Tuberculosis, Bovine TB and Johne’s Disease. Applied Microbiology, 4(1), 341-353. https://doi.org/10.3390/applmicrobiol4010023

Mycobacterial diseases impact millions in the human and veterinary fields each year. Their diagnosis is long and laborious, often only sensitive in the late stages of disease. This has created an unmet need for new diagnostics that are effective in t... Read More about Detecting Closer to Care: Combining Phage and LAMP to Detect Tuberculosis, Bovine TB and Johne’s Disease.

Time-Kill Analysis of Canine Skin Pathogens: A Comparisonof Pradofloxacin and Marbofloxacin (2023)
Journal Article
Pelligand, L., Mead, A., Toutain, P.-L., Bond, R., & Azzariti, S. (2023). Time-Kill Analysis of Canine Skin Pathogens: A Comparisonof Pradofloxacin and Marbofloxacin. Antibiotics, https://doi.org/10.3390/antibiotics12101548

Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv (2022)
Journal Article
Asai, M., Li, Y., Spiropoulos, J., Cooley, W., Everest, D. J., Kendall, S., Martín, C., Robertson, B. D., Langford, P. R., & Newton, S. M. (2022). Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv. Virulence, https://doi.org/10.1080/21505594.2022.2119657

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a leading cause of infectious
disease mortality. Animal infection models have contributed substantially to our understanding of
TB, yet their biological and non-biological limitation... Read More about Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv.

Probing differences in gene essentiality between the human and animal adapted (2021)
Journal Article
Gibson, A. J., Passmore, I. J., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., Clarke, T. G., Sobkowiak, B., Willcocks, S., Werling, D., Villarreal-Ramos, B., Wren, B. W., & Kendall, S. L. (2021). Probing differences in gene essentiality between the human and animal adapted. Frontiers in Veterinary Science,

Members of the Mycobacterium tuberculosis complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, ho... Read More about Probing differences in gene essentiality between the human and animal adapted.

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs (2021)
Journal Article
Vegas Cómitre, M., Cortellini, S., Devreese, M., Roques, B., Bousquet-Melou, A., Toutain, P.-L., & Pelligand, L. (2021). Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs. Journal of Veterinary Medicine, https://doi.org/10.3389/fvets.2021.770202

Background – Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs is lacking and likely differs from healthy dogs.

Hypothesis/Objectives —To describe a population PK model for intravenous amoxicillin clavulanic acid (AMC) in... Read More about Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs.

Molecular basis for DarT ADP-ribosylation of a DNA base (2021)
Journal Article
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., Kendall, S., Goh, S., Stewart, G., & Ahel, I. (2021). Molecular basis for DarT ADP-ribosylation of a DNA base. Nature, https://doi.org/10.1038/s41586-021-03825-4

ADP-ribosyltransferases (ARTs) utilise NAD+ to catalyse substrate ADP-ribosylation, thereby regulating cellular pathways or contributing to toxin-mediated pathogenicity of bacteria. Reversible ADP-ribosylation has traditionally been considered a prot... Read More about Molecular basis for DarT ADP-ribosylation of a DNA base.

Assessment of evaluation tools for integrated surveillance of antimicrobial use and resistance based on selected case studies (2021)
Journal Article
Bennani, H., Sandberg, M., Hesp, A., Aenishaenslin, C., Bordier, M., Bergwerff, U., Chantziaras, I., De Meneghi, D., Ellis-Iversen, J., Filippizi, M.-E., Mintiens, K., R. Nielsen, L., Norström, M., Tomassone, L., van Schaik, G., & Alban, L. (2021). Assessment of evaluation tools for integrated surveillance of antimicrobial use and resistance based on selected case studies. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2021.620998

Regular evaluation of integrated surveillance for antimicrobial use (AMU) and resistance (AMR) in animals, humans and the environment is needed to ensure system effectiveness, but the question is how. In this study, six different evaluation tools wer... Read More about Assessment of evaluation tools for integrated surveillance of antimicrobial use and resistance based on selected case studies.

AMHU Surveillance GB Beef Cattle And Sheep Research Brief 2021 (2021)
Report
Arnold, J., Whatford, L., Payne-Gifford, S., Tak, M., Van Winden, S., Barling, D., & Hӓsler, B. (2021). AMHU Surveillance GB Beef Cattle And Sheep Research Brief 2021. RVC Research Online: Cadogan Trust

Antimicrobial and anthelmintic usage (AMHU) in livestock production has increased over the last 50+ years. Microbial and helminthic exposure to such drugs is understood to have contributed to increased resistance to treatment, causing significant eco... Read More about AMHU Surveillance GB Beef Cattle And Sheep Research Brief 2021.

Systems-thinking approach to identify and assess feasibility of potential interventions to reduce antibiotic use in tilapia farming in Egypt (2021)
Journal Article
Desbois, A., Garza, M., Eltholth, M., Hegazy, Y., Mateus, A., Adams, A., Little, D., Hoeg, E., Vishnumurthy Mohan, C., Ali, S., & Brunton, L. (in press). Systems-thinking approach to identify and assess feasibility of potential interventions to reduce antibiotic use in tilapia farming in Egypt. Aquaculture,

Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits (2021)
Journal Article
Kendall, S. L., Faulkner, V., Cox, A. A., Goh, S., van Bohemen, A., Gibson, A. J., Liebster, O., Wren, B. W., & Willcocks, S. (in press). Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits. Frontiers in Microbiology, 11, https://doi.org/10.3389/fmicb.2020.619427

A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been pre... Read More about Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits.

A Novel TetR-Like Transcriptional Regulator Is Induced in Acid-Nitrosative Stress and Controls Expression of an Efflux Pump in Mycobacteria (2017)
Journal Article
Perrone, F., De Siena, B., Muscariello, L., Kendall, S. L., Waddell, S. J., & Sacco, M. (2017). A Novel TetR-Like Transcriptional Regulator Is Induced in Acid-Nitrosative Stress and Controls Expression of an Efflux Pump in Mycobacteria. Frontiers in Microbiology, 8(2039), https://doi.org/10.3389/fmicb.2017.02039

Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria (2017)
Journal Article
Kamaruzzaman, N. F., Kendall, S. L., & Good, L. (2017). Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria. British Journal of Pharmacology, 174(14), 2225-2236. https://doi.org/10.1111/bph.13664

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis (2016)
Journal Article
Ho, N. A. T., Dawes, S. S., Crowe, A. M., Casabon, I., Gao, C., Kendall, S. L., Baker, E. N., Eltis, L. D., & Lott, J. S. (2016). The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis. Journal of Biological Chemistry, 291(14), 7256-7266. https://doi.org/10.1074/jbc.M115.707760

Cholesterol can be a major carbon source for Mycobacterium tuberculosis during infection, both at an early stage in the macrophage phagosome and later within the necrotic granuloma. KstR is a highly conserved TetR family transcriptional repressor tha... Read More about The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions (2015)
Journal Article
Balhana, R. J. C., Singla, A., Sikder, M. H., Withers, M., & Kendall, S. L. (2015). Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions. BMC Genomics, 16, 479. https://doi.org/10.1186/s12864-015-1696-9

Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis (2014)
Journal Article
Dawes, S. S., Kendall, S. L., Baker, E. N., & Lott, J. S. (2014). Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (keto-steroid regulatory protein) from Mycobacterium tuberculosis. https://doi.org/10.1107/S2053230X14023589

bkaR is a TetR-type repressor that controls an operon associated with branched chain keto-acid metabolism in mycobacteria (2013)
Journal Article
Balhana, R. J. C., Swanston, S. N., Coade, S., Withers, M., Sikder, M. H., Stoker, N. G., & Kendall, S. (2013). bkaR is a TetR-type repressor that controls an operon associated with branched chain keto-acid metabolism in mycobacteria. FEMS Microbiology Letters, 345(2), 132-40. https://doi.org/10.1111/1574-6968.12196

The mycobacterial two-component regulatory systems (2005)
Book Chapter
Kendall, S. (2005). The mycobacterial two-component regulatory systems. . Horizon Bioscience

Rison SCG, Kendall SL, Movahedzadeh F, Stoker NG.. In: Parish T, editor. Mycobacterium Molecular Microbiology.