Skip to main content

Research Repository

Advanced Search

Outputs (139)

Repeated Low‐Level Inflammatory Challenge Leads to Alterations in the TNF‐CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro (2025)
Journal Article
Ritson, M., Xia, D., Wheeler‐Jones, C., & Stolp, H. B. (2025). Repeated Low‐Level Inflammatory Challenge Leads to Alterations in the TNF‐CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro. Journal of Neurochemistry, 169(6), e70130. https://doi.org/10.1111/jnc.70130

The mechanism by which chronic systemic inflammation contributes to cerebral endothelial dysfunction and neurological disorders is unclear, although endothelial inflammatory signalling is considered a cornerstone of this process. Here, we have perfor... Read More about Repeated Low‐Level Inflammatory Challenge Leads to Alterations in the TNF‐CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro.

Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time (2025)
Journal Article
Wattad, S., Bryant, G., Shmuel, M., Smith, H. L., Yaka, R., & Thornton, C. (in press). Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time. International Journal of Molecular Sciences, 26(5), 2131. https://doi.org/10.3390/ijms26052131

Cocaine use is a rising global concern, and increased use is accompanied by
a significant increase in people entering treatment for the first time. However, there are
still no complete therapies, and preclinical tools are necessary to both understa... Read More about Cocaine Differentially Affects Mitochondrial Function Depending on Exposure Time.

Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon (2025)
Journal Article
Beaumont, R. E., Smith, E. J., David, C., Paterson, Y. Z., Faull, E., & Guest, D. J. (2025). Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon. Cells & Development, https://doi.org/10.1016/j.cdev.2025.204003

Tendon injuries are a common problem in humans and horses. There is a high re-injury rate in both species due to the poor regeneration of adult tendon and the resulting formation of scar tissue. In contrast, fetal tendon injuries undergo scarless reg... Read More about Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon.

Identification of a global gene expression signature associated with the genetic risk of catastrophic fracture in iPSC-derived osteoblasts from Thoroughbred horses (2025)
Journal Article
Palomino Lago, E., Ross, A., McClellan, A., & Guest, D. (2025). Identification of a global gene expression signature associated with the genetic risk of catastrophic fracture in iPSC-derived osteoblasts from Thoroughbred horses. Animal Genetics, https://doi.org/10.1111/age.13504

Bone fractures are a significant problem in Thoroughbred racehorses. The risk of fracture is influenced by both genetic and environmental factors. To determine the biological processes that are affected in genetically susceptible horses, we utilised... Read More about Identification of a global gene expression signature associated with the genetic risk of catastrophic fracture in iPSC-derived osteoblasts from Thoroughbred horses.

Regenerative Medicine and Biological Treatments (2024)
Book Chapter
Guest, D., Schramme, M., & Smith, R. (2024). Regenerative Medicine and Biological Treatments. In Essential Facts of Equine Physical Therapy, Rehabilitation and Sports Medicine

Many tissues undergo poor natural regeneration following injury or disease and the reparative healing process can lead to tissues that are functionally inferior and prone to re-injury. Regenerative medicine aims to induce natural tissue regeneration... Read More about Regenerative Medicine and Biological Treatments.

Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro (2024)
Journal Article
Curel, C. J. M., Nobeli, I., & Thornton, C. (2024). Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro. Cells, 13(7), 631. https://doi.org/10.3390/cells13070631

Neonatal hypoxia-ischemia (HI) affects 2-3 per 1000 live births in developed countries and up to 26 per 1000 live births in developing countries. It is estimated that of the 750,000 infants experiencing a hypoxic-ischemic event during birth per year,... Read More about Leflunomide Treatment Does Not Protect Neural Cells Following Oxygen-Glucose Deprivation (OGD) In Vitro.

Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes (2024)
Journal Article
Smith, E. J., Beaumont, R. E., Dudhia, J., & Guest, D. J. (in press). Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-024-10693-8

Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contribut... Read More about Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.

Feline Comorbidities: Hypersomatotropism-induced diabetes in cats (2024)
Journal Article
Scudder, C., & Church, D. (2024). Feline Comorbidities: Hypersomatotropism-induced diabetes in cats. Journal of Feline Medicine and Surgery, 26(2), https://doi.org/10.1177/1098612x241226690

Practical relevance:
Diabetes mellitus is the second-most common feline endocrinopathy, affecting an estimated 1/200 cats. While the underlying causes vary, around 15-25% of cats with diabetes mellitus develop the condition secondarily to progressiv... Read More about Feline Comorbidities: Hypersomatotropism-induced diabetes in cats.

A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses (2023)
Journal Article
Lago, E. P., Baird, A., Blott, S. C., Mcphail, R. E., Ross, A. C., Durward-Akhurst, S. A., & Guest, D. J. (2023). A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses. Animals, 14(1), 116. https://doi.org/10.3390/ani14010116

Fractures caused by bone overloading are a leading cause of euthanasia in Thoroughbred racehorses. The risk of fatal fracture has been shown to be influenced by both environmental and genetic factors but, to date, no specific genetic mechanisms unde... Read More about A Functional Single-Nucleotide Polymorphism Upstream of the Collagen Type III Gene Is Associated with Catastrophic Fracture Risk in Thoroughbred Horses.

PROSPECTIVE EVALUATION OF PLATELET FUNCTION AND FIBRINOLYSIS IN 20 DOGS WITH TRAUMA (2023)
Journal Article
Cortellini, S., Chan, D., McBride, D., & Birkbeck, R. (in press). PROSPECTIVE EVALUATION OF PLATELET FUNCTION AND FIBRINOLYSIS IN 20 DOGS WITH TRAUMA. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.13356

Objectives: To determine platelet function and fibrinolysis in dogs following trauma using multiple electrical impedance aggregometry and a modified thromboelastographic technique. To determine if the severity of trauma, as assessed by the Animal Tr... Read More about PROSPECTIVE EVALUATION OF PLATELET FUNCTION AND FIBRINOLYSIS IN 20 DOGS WITH TRAUMA.

BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction (2023)
Journal Article
Menzies-Gow, N., Knowles, E., & Hart, N. (in press). BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction. Equine Veterinary Journal, https://doi.org/10.1111/evj.14009

Background: Pituitary pars intermedia dysfunction (PPID) is a prevalent, age-related chronic disorder in equids. Diagnosis of PPID can be challenging because of its broad spectrum of clinical presentations and disparate published diagnostic criteria,... Read More about BEVA primary care clinical guidelines: Diagnosis and management of equine pituitary pars intermedia dysfunction.

Mechanosignalling pathways that regulate endothelial barrier function (2023)
Journal Article
McQueen, A., & Warboys, C. M. (2023). Mechanosignalling pathways that regulate endothelial barrier function. Current Opinion in Cell Biology, 84, 102213. https://doi.org/10.1016/j.ceb.2023.102213

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly regulated, and increased permeability is associated with a number... Read More about Mechanosignalling pathways that regulate endothelial barrier function.

Metformin and empagliflozin combination modulate macrophage inflammatory gene expression (2023)
Journal Article
Arefin, A., & Gage, M. C. (2023). Metformin and empagliflozin combination modulate macrophage inflammatory gene expression. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24054785

Type-2 Diabetes Mellitus is a complex, chronic illness characterized by persistent high blood glucose levels. Patients can be described anti diabetes drugs as single agents or in combination depending on the severity of their condition. Metformin and... Read More about Metformin and empagliflozin combination modulate macrophage inflammatory gene expression.

A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis (2023)
Journal Article
Elliott, J. (2023). A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis. Equine Veterinary Journal, https://doi.org/10.1111/evj.13933

Equine laminitis has both fascinated and frustrated veterinary researchers and clinicians for many years. The recognition that many ponies suffering from pasture associated laminitis have an insulin dysregulated phenotype (endocrinopathic laminitis,... Read More about A review of cellular and molecular mechanisms in endocrinopathic, sepsis-related and supporting limb equine laminitis.

Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors (2022)
Journal Article
Guest, D., Smith, E., Beaumont, R., McClellan, A., Sze, C., Palomino Lago, E., Hazelgrove, L., Dudhia, J., & Smith, R. (in press). Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors. Cell and Tissue Research, https://doi.org/10.1007/s00441-022-03726-6

Tendon injuries occur commonly in both human and equine athletes, and poor tendon regeneration leads to functionally
deficient scar tissue and an increased frequency of re-injury. Despite evidence suggesting inadequate resolution of inflammation
le... Read More about Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity (2022)
Journal Article
Yates, A., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A., Goikolea-Vives, A., Cai, V., Alkhader, L., Saland, A., Hammond, B., Dimitrova, R., Batalle, D., Fernandes, C., Edwards, A. D., Gressens, P., Thornton, C., & Stolp, H. (in press). Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity. Journal of Neuroinflammation, https://doi.org/10.1186/s12974-022-02625-5

Encephalopathy of prematurity (EoP) affects approximately 30% of infants born <32 weeks gestation and is highly associated with inflammation in the foetus. Here we evaluated the efficacy of Montelukast, a cysteinyl leukotriene receptor antagonist wid...