Mechanosignalling pathways that regulate endothelial barrier function

McQueen, Anna; Warboys, Christina M.

Abstract

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly regulated, and increased permeability is associated with a number of diseases including atherosclerosis. Endothelial cells are continuously exposed to mechanical forces exerted by flowing blood and are particularly sensitive to shear stress, which is a key determinant of endothelial function. Undisturbed flow promotes endothelial resilience and reduces permeability to macromolecules whereas disturbed flow promotes endothelial dysfunction and barrier disruption. This review will outline recent advances in our understanding of how disturbed and undisturbed flow regulate paracellular and transcellular permeability and will highlight potential cellular targets that could form the basis of therapies to limit the development of cardiovascular disease

Citation

McQueen, A., & Warboys, C. M. (2023). Mechanosignalling pathways that regulate endothelial barrier function. Current Opinion in Cell Biology, 84, 102213. https://doi.org/10.1016/j.ceb.2023.102213

• Journal Article Type: Article
• Acceptance Date: Jul 4, 2023
• Online Publication Date: Jul 31, 2023
• Publication Date: 2023-10
• Deposit Date: Aug 1, 2023
• Publicly Available Date: Aug 1, 2023
• Journal: Current Opinion in Cell Biology
• Print ISSN: 0955-0674
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 84
• Pages: 102213
• DOI: https://doi.org/10.1016/j.ceb.2023.102213
• Keywords: Cell Biology
• Additional Information: This article is maintained by: Elsevier; Article Title: Mechanosignalling pathways that regulate endothelial barrier function; Journal Title: Current Opinion in Cell Biology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.ceb.2023.102213; Content Type: article; Copyright: © 2023 The Author(s). Published by Elsevier Ltd.