Skip to main content

Research Repository

Advanced Search

Outputs (130)

Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis (2024)
Journal Article
Gap-Gaupool, B., Glenn, S. M., Milburn, E., Turapov, O., Crosatti, M., Hincks, J., Stewart, B., Bacon, J., Kendall, S. L., Voskuil, M. I., Riabova, O., Monakhova, N., Green, J., Waddell, S. J., Makarov, V. A., & Mukamolova, G. V. (in press). Nitric oxide induces the distinct invisibility phenotype of Mycobacterium tuberculosis. Communications Biology, 7(1), https://doi.org/10.1038/s42003-024-06912-0

Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv (2022)
Journal Article
Asai, M., Li, Y., Spiropoulos, J., Cooley, W., Everest, D. J., Kendall, S., Martín, C., Robertson, B. D., Langford, P. R., & Newton, S. M. (2022). Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv. Virulence, https://doi.org/10.1080/21505594.2022.2119657

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a leading cause of infectious
disease mortality. Animal infection models have contributed substantially to our understanding of
TB, yet their biological and non-biological limitation... Read More about Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv.

Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria (2022)
Journal Article
Gibson, A. J., Stiens, J., Passmore, I. J., Faulkner, V., Miculob, J., Willcocks, S., Coad, M., Berg, S., Werling, D., Wren, B. W., Nobeli, I., Villarreal-Ramos, B., & Kendall, S. L. (2022). Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria. mBio, https://doi.org/10.1128/mbio.00672-22

Tuberculosis has severe impacts in both humans and animals. Understanding the genetic basis of survival of both Mycobacterium tuberculosis, the human adapted species, and Mycobacterium bovis, the animal adapted species is crucial to deciphering the b... Read More about Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria.

Probing differences in gene essentiality between the human and animal adapted (2021)
Journal Article
Gibson, A. J., Passmore, I. J., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., Clarke, T. G., Sobkowiak, B., Willcocks, S., Werling, D., Villarreal-Ramos, B., Wren, B. W., & Kendall, S. L. (2021). Probing differences in gene essentiality between the human and animal adapted. Frontiers in Veterinary Science,

Members of the Mycobacterium tuberculosis complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, ho... Read More about Probing differences in gene essentiality between the human and animal adapted.

Molecular basis for DarT ADP-ribosylation of a DNA base (2021)
Journal Article
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., Kendall, S., Goh, S., Stewart, G., & Ahel, I. (2021). Molecular basis for DarT ADP-ribosylation of a DNA base. Nature, https://doi.org/10.1038/s41586-021-03825-4

ADP-ribosyltransferases (ARTs) utilise NAD+ to catalyse substrate ADP-ribosylation, thereby regulating cellular pathways or contributing to toxin-mediated pathogenicity of bacteria. Reversible ADP-ribosylation has traditionally been considered a prot... Read More about Molecular basis for DarT ADP-ribosylation of a DNA base.

Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression (2020)
Journal Article
Tng, P. Y. L., Carabajal Paladino, L., Verkuijl, S. A. N., Purcell, J., Merits, A., Leftwich, P. T., Fragkoudis, R., Noad, R., & Alphey, L. (2020). Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression. Communications Biology, 3(1), https://doi.org/10.1038/s42003-020-01142-6

Aedes aegypti and Aedes albopictus mosquitoes are vectors of the RNA viruses chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The
development of new methods to generate virus-refractory mosquitoes would be benef... Read More about Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression.

Analysis of Genetic Variation in the Bovine SLC11A1 Gene, Its Influence on the Expression of NRAMP1 and Potential Association With Resistance to Bovine Tuberculosis (2020)
Journal Article
Holder, A., Garty, R., Elder, C., Mesnard, P., Laquerbe, C., Bartens, M.-C., Salavati, M., Shabbir, M., Tzelos, T., Connelly, T., Villarreal-Ramos, B., & Werling, D. (2020). Analysis of Genetic Variation in the Bovine SLC11A1 Gene, Its Influence on the Expression of NRAMP1 and Potential Association With Resistance to Bovine Tuberculosis. Frontiers in Microbiology, 11, https://doi.org/10.3389/fmicb.2020.01420

Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic zoonotic disease where host genetics is thought to contribute to susceptibility or resistance. One of the genes implicated is the SLC11A1 gene, that encodes for the natural resist... Read More about Analysis of Genetic Variation in the Bovine SLC11A1 Gene, Its Influence on the Expression of NRAMP1 and Potential Association With Resistance to Bovine Tuberculosis.

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis (2020)
Journal Article
Moreira-Teixeira, L., Tabone, O., Graham, C. M., Singhania, A., Stavropoulos, E., Redford, P. S., Chakravarty, P., Priestnall, S. L., Suarez-Bonnet, A., Herbert, E., Mayer-Barber, K. D., Sher, A., Fonseca, K. L., Sousa, J., Cá, B., Verma, R., Haldar, P., Saraiva, M., & O’Garra, A. (2020). Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis. Nature Immunology, 21(4), 464-476. https://doi.org/10.1038/s41590-020-0610-z

Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here... Read More about Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice (2019)
Journal Article
Ying Wu, Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., Gribben, J., Xia, D., & Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been i... Read More about Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice.

Administration of a Synbiotic Containing Enterococcus faecium Does Not Significantly Alter Fecal Microbiota Richness or Diversity in Dogs With and Without Food-Responsive Chronic Enteropathy (2019)
Journal Article
Pilla, R., Guard, B. C., Steiner, J. M., Gaschen, F. P., Olson, E., Werling, D., Allenspach, K., Schmitz, S. S., & Suchodolski, J. S. (2019). Administration of a Synbiotic Containing Enterococcus faecium Does Not Significantly Alter Fecal Microbiota Richness or Diversity in Dogs With and Without Food-Responsive Chronic Enteropathy. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2019.00277

Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control (2019)
Journal Article
Worsley, A., Vassileva, K., Tsui, J., Song, W., & Good, L. (2019). Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control. Polymers, 11(5), 915. https://doi.org/10.3390/polym11050915

Polyhexamethylene biguanide (PHMB) is a broad-spectrum antiseptic which avoids many efficacy and toxicity problems associated with antimicrobials, in particular, it has a low risk of loss of susceptibility due to acquired antimicrobial resistance. De... Read More about Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control.

The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage (2018)
Journal Article
Osborne, C., West, E., & Bate, C. (2018). The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage. Journal of Cell Science, 131(8), https://doi.org/10.1242/jcs.211789

The cellular prion protein (PrPC) acts as a scaffold protein that organises signalling complexes. In synaptosomes, the aggregation of PrPC by amyloid-β (Aβ) oligomers attracts and activates cytoplasmic phospholipase A2 (cPLA2), leading to synapse deg... Read More about The phospholipase A2 pathway controls a synaptic cholesterol ester cycle and synapse damage.

Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers (2018)
Journal Article
McHale-Owen, H., & Bate, C. (2018). Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers. https://doi.org/10.1016/j.bbadis.2017.12.017

The production of amyloid-β (Aβ) is the key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of Aβ within the brain cause synapse degeneration and the dementia that is characteristic of AD. Here the factors that affe... Read More about Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-beta oligomers.

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß (2017)
Journal Article
West, E., Osborne, C., & Bate, C. (2017). The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß. Journal of Cell Science, 130, 3050-3059. https://doi.org/10.1242/jcs.205484

Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol conc... Read More about The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß.

Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-ß oligomers (2017)
Journal Article
Nolan, W., McHale-Owen, H., & Bate, C. (2017). Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-ß oligomers. Biochemical Journal, 474(17), 3045-3058. https://doi.org/10.1042/BCJ20170239

The production of amyloid-β (Aβ) is a key factor driving pathogenesis in Alzheimer's disease (AD). Increasing concentrations of soluble Aβ oligomers within the brain lead to synapse degeneration and the progressive dementia characteristic of AD. Sinc... Read More about Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-ß oligomers.

Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers (2017)
Journal Article
Harris, K. A., Freidl, G. S., Munoz, O. S., Von Dobschuetz, S., De Nardi, M., Wieland, B., Koopmans, M. P. G., Staerk, K. D. C., Van Reeth, K., Dauphin, G., Meijer, A., De Bruin, E., Capua, I., Hill, A., Kosmider, R., Banks, J., Stevens, K. B., Van Der Werf, S., Enouf, V., Van Der Meulen, K., …FLURISK Consortium. (2017). Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers. EcoHealth, 14(2), 342-360. https://doi.org/10.1007/s10393-017-1244-y

Drivers and risk factors for Influenza A virus transmission across species barriers are poorly understood, despite the ever present threat to human and animal health potentially on a pandemic scale. Here we review the published evidence for epidemiol... Read More about Epidemiological Risk Factors for Animal Influenza A Viruses Overcoming Species Barriers.

Are Eimeria Genetically Diverse, and Does It Matter? (2017)
Journal Article
Clark, E. L., Tomley, F. M., & Blake, D. P. (2017). Are Eimeria Genetically Diverse, and Does It Matter?. Trends in Parasitology, 33(3), 231-241. https://doi.org/10.1016/j.pt.2016.08.007

Eimeria pose a risk to all livestock species as a cause of coccidiosis, reducing productivity and compromising animal welfare. Pressure to reduce drug use in the food chain makes the development of cost-effective vaccines against Eimeria essential. F... Read More about Are Eimeria Genetically Diverse, and Does It Matter?.