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Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice

Ying Wu; Chang, Y M; Stell, A J; Priestnall, S L; Sharma, E; Goulart, M R; Gribben, J; Xia, D; Garden, O A

Authors

Ying Wu

Y M Chang

A J Stell

S L Priestnall

E Sharma

M R Goulart

J Gribben

D Xia

O A Garden



Abstract

Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations of Tregs correlate with pathogenesis of inflammatory, autoimmune and neoplastic disorders. Phenotypically and functionally distinct subsets of Tregs have been identified in humans and mice on the basis of their extensive portfolios of monoclonal antibodies (mAb) against Treg surface antigens. As an important veterinary species, dogs are increasingly recognised as an excellent model for many human diseases. However, insightful study of canine Tregs has been restrained by the limited availability of mAb. We therefore set out to characterise CD4+CD25high T cells isolated ex vivo from healthy dogs and showed that they possess a regulatory phenotype, function, and transcriptomic signature that resembles those of human and murine Tregs. By launching a cross-species comparison, we unveiled a conserved transcriptomic signature of Tregs and identified that transcript hip1 may have implications in Treg function.

Citation

Ying Wu, , Chang, Y. M., Stell, A. J., Priestnall, S. L., Sharma, E., Goulart, M. R., …Garden, O. A. (2019). Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. https://doi.org/10.1038/s41598-019-50065-8

Journal Article Type Article
Acceptance Date Sep 5, 2019
Publication Date Sep 17, 2019
Deposit Date Sep 6, 2019
Publicly Available Date Oct 11, 2019
Journal Scientific Reports (Nature)
Peer Reviewed Peer Reviewed
Volume 9
Issue 13478
DOI https://doi.org/10.1038/s41598-019-50065-8
Public URL https://rvc-repository.worktribe.com/output/1380423

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