Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor (2021)
Journal Article
Pang, K. T., Ghim, M., Liu, C., Tay, H. M., Fhu, C. W., Chia, R. N., Qiu, B., Sarathchandra, P., Chester, A. H., Yacoub, M. H., Wilkinson, F. L., Weston, R., Warboys, C. M., Hou, H. W., Weinberg, P. D., & Wang, X. (2021). Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers in Cell and Developmental Biology, 9, https://doi.org/10.3389/fcell.2021.706143

Elevated serum concentrations of leucine-rich α-2-glycoprotein (LRG1) have been reported in patients with inflammatory, autoimmune, and cardiovascular diseases. This study aims to investigate the role of LRG1 in endothelial activation. LRG1 in endoth... Read More about Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.

Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium (2021)
Journal Article
Cheng, Z., Wang, K., Thomas, C., Zhang, S., & Wathes, D. C. (2021). Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium. Frontiers in Veterinary Science,

Bovine Viral Diarrhoea virus (BVDV) is a pestivirus with a single-stranded, positive sense RNA genome. It is endemic in many cattle populations, causing major economic losses in part due to reduced fertility. BVDV exhibits great genetic diversity an... Read More about Comparison of the Ability of High and Low Virulence Strains of noncytopathic Bovine Viral Diarrhoea Virus-1 to Modulate Expression of Interferon Tau Stimulated Genes in Bovine Endometrium.

Commonly diagnosed disorders in UK dogs under primary veterinary care: Results and applications (2021)
Data
O'Neill, D. (2021). Commonly diagnosed disorders in UK dogs under primary veterinary care: Results and applications. [Data]. https://doi.org/10.34840/dv1y-t051

Characterisation and mapping of the surveillance system for Antimicrobial Resistance and Antimicrobial Use in the United Kingdom (2021)
Journal Article
Bennani, H., Cornelsen, L., Stärk, K., & Häsler, B. (2021). Characterisation and mapping of the surveillance system for Antimicrobial Resistance and Antimicrobial Use in the United Kingdom. Veterinary Record, https://doi.org/10.1002/vetr.10

Background: Surveillance of antimicrobial resistance (AMR) is an essential component of any strategy to mitigate AMR and needs regular evaluation to ensure its effectiveness. A first step for any evaluation is to describe the system and context. In t... Read More about Characterisation and mapping of the surveillance system for Antimicrobial Resistance and Antimicrobial Use in the United Kingdom.

Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Faccenda, D., Alvarex, M. S., Mainenti, M., Kuhlman Hussy, L., Bentham, R., Szabadkai, G., Zappulli, V., Dhoot, G., Fleck, R. A., Vizcay-Barrena, G., Smith, K., & Campanella, M. (2020). Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response. Science Advances, https://doi.org/10.1101/445411

Cholesterol metabolism is pivotal to cellular homeostasis, hormones production, and membranes composition. Its dysregulation associates with malignant reprogramming and therapy resistance. Cholesterol is trafficked into the mitochondria for steroidog... Read More about Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Rigon, M., Faccenda, D., Alvarez, M. S., Singh, A., Mainenti, M., Hussey, L. K., Bentham, R., Szabadkai, G., Zappulli, V., Dhoot, G., Romano, L. E., Dong, X., Coppens, I., Hamacher-Brady, A., Chapple, J. P., Abeti, R., …Campanella, M. (in press). Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response. Science Advances, https://doi.org/10.1101/445411

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as Mitochondrial Retrograde Response (MRR) and is induced by mitochondrial dysfunctions. MRR results in the nuclear stabilization of pro-s... Read More about Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response.

Incidence and risk factors for feline lymphoma in UK primary-care practice (2020)
Journal Article
Economu, L. (in press). Incidence and risk factors for feline lymphoma in UK primary-care practice. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13266

Objectives: The study aimed to estimate the incidence and prevalence of feline lymphoma in cats attending primary-care practices across the UK and to identify patient-based and environmental (radon and pesticide exposure) risk factors.

Materials a... Read More about Incidence and risk factors for feline lymphoma in UK primary-care practice.

Prospective evaluation of pericardial catheter placement versus needle pericardiocentesis in the management of canine pericardial effusion (2020)
Journal Article
Cook, S. (2020). Prospective evaluation of pericardial catheter placement versus needle pericardiocentesis in the management of canine pericardial effusion. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.13030

Objective
To compare the safety and efficacy of pericardial catheter placement with needle pericardiocentesis in dogs with pericardial effusion (PE)
Design
Prospective, pilot randomized trial.
Setting
University teaching hospital.
Animals
Thir... Read More about Prospective evaluation of pericardial catheter placement versus needle pericardiocentesis in the management of canine pericardial effusion.

Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy (2020)
Journal Article
Andreas Berk, B., Packer, R. M. A., Hong Law, T., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., Knebel, A., Tipold, A., Pelligand, L., & Volk, H. A. (in press). Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy. Epilepsy & Behavior, https://doi.org/10.1016/j.yebeh.2020.107608

Objective: Cognitive impairments (CI) have recently been identified in canine epilepsy patients. A medium-chain triglyceride (MCT) enriched diet has been demonstrated to improve cognition in aged dogs and seizure control in canine epilepsy. This stud... Read More about Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy.

Modelling the fate of hepatitis E virus during slaughtering of pigs (2020)
Journal Article
Crotta, M., Lavazza, A., Mateus, A. L. P., & Guitian, J. (in press). Modelling the fate of hepatitis E virus during slaughtering of pigs. International Journal of Food Microbiology,

Dogs don’t just die in hot cars – fatality and risk factors for triggers of heat-related illness (heatstroke) in UK dogs (2020)
Data
O'Neill, D. Dogs don’t just die in hot cars – fatality and risk factors for triggers of heat-related illness (heatstroke) in UK dogs. [Data]. https://doi.org/10.34840/jy1y-cp44

Canine tonsillar polyps: characteristics, classification and review of the pathogenesis (2020)
Journal Article
Molin, J., Vilafranca Compte, M., Suárez-Bonnet, A., Altimira, J., & Ramírez, G. (2020). Canine tonsillar polyps: characteristics, classification and review of the pathogenesis. Veterinary Pathology,

Canine tonsillar polyps are uncommon. We describe 14 tonsillar polyps in dogs and review their classification and pathogenesis. All dogs were adult (3-13 years old). Females (10/14) were more affected than males (4/14). Most of the lesions were asymp... Read More about Canine tonsillar polyps: characteristics, classification and review of the pathogenesis.

Helping to heal nature and ourselves through human-rights-based and gender-responsive One Health (2020)
Journal Article
Garnier, J., Savic, S., Boriani, E., Bagnol, B., Häsler, B., & Kock, R. (2020). Helping to heal nature and ourselves through human-rights-based and gender-responsive One Health. One Health Outlook, 2(1), 22. https://doi.org/10.1186/s42522-020-00029-0

Abstract: The health of our planet and humanity is threatened by biodiversity loss, disease and climate crises that are unprecedented in human history, driven by our insatiable consumption and unsustainable production patterns, particularly food syst... Read More about Helping to heal nature and ourselves through human-rights-based and gender-responsive One Health.

The new age of renal biomarkers: does SDMA solve all of our problems? (2020)
Journal Article
Sargent, H. J., Elliott, J., & Jepson, R. E. (2020). The new age of renal biomarkers: does SDMA solve all of our problems?. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13236

Within clinical small animal practice, diagnosis of both chronic kidney disease and acute kidney injury is common. To assess renal function, measurement of glomerular filtration rate is considered the gold standard. Currently, routine tests of kidney... Read More about The new age of renal biomarkers: does SDMA solve all of our problems?.

Foraging efficiency, social status and body condition in group-living horses and ponies (2020)
Journal Article
Giles, S., Harris, P. A., Rands, S. A., & Nicol, C. J. (2020). Foraging efficiency, social status and body condition in group-living horses and ponies. PeerJ, https://doi.org/10.7717/peerj.10305

Individual animals experience different costs and benefits associated with group living, which may impact on their foraging efficiency in ways not yet well specified. This study investigated associations between social dominance, body condition and i... Read More about Foraging efficiency, social status and body condition in group-living horses and ponies.

A review of phosphorus homeostasis and the impact of different types and amounts of dietary phosphate on metabolism and renal health in cats (2020)
Journal Article
Laflamme, D., Backus, R., Brown, S., Butterwick, R., Czarnecki‐Maulden, G., Elliott, J., Fascetti, A., & Polzin, D. (2020). A review of phosphorus homeostasis and the impact of different types and amounts of dietary phosphate on metabolism and renal health in cats. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15961

Elevated concentrations of serum phosphate are linked with progression and increased case fatality rate in animals and humans with chronic kidney disease. Elevated concentrations of serum phosphate can be a risk factor for development of renal and ca... Read More about A review of phosphorus homeostasis and the impact of different types and amounts of dietary phosphate on metabolism and renal health in cats.

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis (2020)
Journal Article
Moreira-Teixeira, L., Stimpson, P. J., Stavropoulos, E., Hadebe, S., Chakravarty, P., Ioannou, M., Aramburu, I. V., Herbert, E., Priestnall, S. L., Suarez-Bonnet, A., Sousa, J., Fonseca, K. L., Wang, Q., Vashakidze, S., Rodríguez-Martínez, P., Vilaplana, C., Saraiva, M., Papayannopoulos, V., & O’Garra, A. (2020). Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis. Nature Communications, 11(1), 5566. https://doi.org/10.1038/s41467-020-19412-6

Abstract: Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were sh... Read More about Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses (2020)
Journal Article
Escalera-Zamudio, M., Golden, M., Gutiérrez, B., Thézé, J., Keown, J. R., Carrique, L., Bowden, T. A., & Pybus, O. G. (2020). Parallel evolution in the emergence of highly pathogenic avian influenza A viruses. Nature Communications, 11(1), 5511. https://doi.org/10.1038/s41467-020-19364-x

Abstract: Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses (AIV). Highly-pathogenic AIVs evolv... Read More about Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.

Seizures in dogs under primary veterinary care in the United Kingdom: Etiology, diagnostic testing, and clinical management (2020)
Journal Article
Erlen, A., Potschka, H., Volk, H. A., Sauter‐Louis, C., & O'Neill, D. G. (2020). Seizures in dogs under primary veterinary care in the United Kingdom: Etiology, diagnostic testing, and clinical management. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15911

Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds (2020)
Journal Article
Denyer, A. L., Massey, J. P., Davison, L. J., Ollier, W. E. R., Catchpole, B., & Kennedy, L. J. (2020). Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds. Canine Medicine and Genetics, 7(1), 15. https://doi.org/10.1186/s40575-020-00093-9

Abstract: Background: Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, including immune-me... Read More about Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds.